Independent effects of pregnancy induced hypertension on childhood development

a retrospective cohort study

Eleanor R. Love, Jackie Crum, Sohinee Bhattacharya

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Objective
To assess whether maternal hypertension in pregnancy was independently associated with additional support needs in children.

Study design
Retrospective cohort study using linkage of birth records of all singleton deliveries occurring in primigravidae between 1995 and 2008 in Aberdeen Maternity and Neonatal Databank with the Support Needs System (SNS) dataset in Grampian. Crude and adjusted odds ratios with 95% confidence intervals of having a record in SNS in the presence of maternal pregnancy induced hypertension were calculated using logistic regression taking account of confounders such as preterm birth and low birth weight.

Results
After adjusting for confounding factors, neither pre-eclampsia {Adj OR 0.80 (95% CI 0.60, 1.07)} nor gestational hypertension {Adj OR 1.16 (95% CI 0.99, 1.36)} showed statistically significant associations with additional support needs. An association of pre-eclampsia with cerebral palsy seen on univariate analysis also disappeared on adjusting for confounders {Adj OR 1.26 (95% CI 0.43, 3.68)}. Birth before 32 weeks gestation and birthweight below 1500 g were independently associated with additional support needs in children.

Conclusions
While maternal hypertension was not found to be independently associated with special needs in children, very preterm birth and very low birthweight showed an association.
Original languageEnglish
Pages (from-to)219-224
Number of pages6
JournalEuropean Journal of Obstetrics & Gynecology and Reproductive Biology
Volume165
Issue number2
DOIs
Publication statusPublished - Dec 2012

Fingerprint

Pregnancy Induced Hypertension
Cohort Studies
Retrospective Studies
Premature Birth
Mothers
Pre-Eclampsia
Hypertension
Birth Certificates
Pregnancy
Low Birth Weight Infant
Cerebral Palsy
Logistic Models
Odds Ratio
Parturition
Databases
Confidence Intervals

Keywords

  • preeclampsia
  • gestational hypertension
  • additional support needs

Cite this

@article{fe48a24da23f4598a42f7b5967cb5417,
title = "Independent effects of pregnancy induced hypertension on childhood development: a retrospective cohort study",
abstract = "ObjectiveTo assess whether maternal hypertension in pregnancy was independently associated with additional support needs in children.Study designRetrospective cohort study using linkage of birth records of all singleton deliveries occurring in primigravidae between 1995 and 2008 in Aberdeen Maternity and Neonatal Databank with the Support Needs System (SNS) dataset in Grampian. Crude and adjusted odds ratios with 95{\%} confidence intervals of having a record in SNS in the presence of maternal pregnancy induced hypertension were calculated using logistic regression taking account of confounders such as preterm birth and low birth weight.ResultsAfter adjusting for confounding factors, neither pre-eclampsia {Adj OR 0.80 (95{\%} CI 0.60, 1.07)} nor gestational hypertension {Adj OR 1.16 (95{\%} CI 0.99, 1.36)} showed statistically significant associations with additional support needs. An association of pre-eclampsia with cerebral palsy seen on univariate analysis also disappeared on adjusting for confounders {Adj OR 1.26 (95{\%} CI 0.43, 3.68)}. Birth before 32 weeks gestation and birthweight below 1500 g were independently associated with additional support needs in children.ConclusionsWhile maternal hypertension was not found to be independently associated with special needs in children, very preterm birth and very low birthweight showed an association.",
keywords = "preeclampsia, gestational hypertension, additional support needs",
author = "Love, {Eleanor R.} and Jackie Crum and Sohinee Bhattacharya",
year = "2012",
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doi = "10.1016/j.ejogrb.2012.08.015",
language = "English",
volume = "165",
pages = "219--224",
journal = "European Journal of Obstetrics & Gynecology and Reproductive Biology",
issn = "0301-2115",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

TY - JOUR

T1 - Independent effects of pregnancy induced hypertension on childhood development

T2 - a retrospective cohort study

AU - Love, Eleanor R.

AU - Crum, Jackie

AU - Bhattacharya, Sohinee

PY - 2012/12

Y1 - 2012/12

N2 - ObjectiveTo assess whether maternal hypertension in pregnancy was independently associated with additional support needs in children.Study designRetrospective cohort study using linkage of birth records of all singleton deliveries occurring in primigravidae between 1995 and 2008 in Aberdeen Maternity and Neonatal Databank with the Support Needs System (SNS) dataset in Grampian. Crude and adjusted odds ratios with 95% confidence intervals of having a record in SNS in the presence of maternal pregnancy induced hypertension were calculated using logistic regression taking account of confounders such as preterm birth and low birth weight.ResultsAfter adjusting for confounding factors, neither pre-eclampsia {Adj OR 0.80 (95% CI 0.60, 1.07)} nor gestational hypertension {Adj OR 1.16 (95% CI 0.99, 1.36)} showed statistically significant associations with additional support needs. An association of pre-eclampsia with cerebral palsy seen on univariate analysis also disappeared on adjusting for confounders {Adj OR 1.26 (95% CI 0.43, 3.68)}. Birth before 32 weeks gestation and birthweight below 1500 g were independently associated with additional support needs in children.ConclusionsWhile maternal hypertension was not found to be independently associated with special needs in children, very preterm birth and very low birthweight showed an association.

AB - ObjectiveTo assess whether maternal hypertension in pregnancy was independently associated with additional support needs in children.Study designRetrospective cohort study using linkage of birth records of all singleton deliveries occurring in primigravidae between 1995 and 2008 in Aberdeen Maternity and Neonatal Databank with the Support Needs System (SNS) dataset in Grampian. Crude and adjusted odds ratios with 95% confidence intervals of having a record in SNS in the presence of maternal pregnancy induced hypertension were calculated using logistic regression taking account of confounders such as preterm birth and low birth weight.ResultsAfter adjusting for confounding factors, neither pre-eclampsia {Adj OR 0.80 (95% CI 0.60, 1.07)} nor gestational hypertension {Adj OR 1.16 (95% CI 0.99, 1.36)} showed statistically significant associations with additional support needs. An association of pre-eclampsia with cerebral palsy seen on univariate analysis also disappeared on adjusting for confounders {Adj OR 1.26 (95% CI 0.43, 3.68)}. Birth before 32 weeks gestation and birthweight below 1500 g were independently associated with additional support needs in children.ConclusionsWhile maternal hypertension was not found to be independently associated with special needs in children, very preterm birth and very low birthweight showed an association.

KW - preeclampsia

KW - gestational hypertension

KW - additional support needs

U2 - 10.1016/j.ejogrb.2012.08.015

DO - 10.1016/j.ejogrb.2012.08.015

M3 - Article

VL - 165

SP - 219

EP - 224

JO - European Journal of Obstetrics & Gynecology and Reproductive Biology

JF - European Journal of Obstetrics & Gynecology and Reproductive Biology

SN - 0301-2115

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ER -