Indices of cardiovascular function derived from peripheral pulse wave analysis using radial applanation tonometry

a measurement repeatability study

Mike Crilly, Christoph Coch, Margaret Bruce, Hazel Clark, David Williams

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Pulse wave analysis (PWA) using applanation tonometry is a non-invasive technique for assessing cardiovascular function. It produces three important indices: ejection duration index (ED%), augmentation index adjusted for heart rate (AIX@75), and subendocardial viability ratio (SEVR%). The aim of this study was to assess within- and between-observer repeatability of these measurements. After resting supine for 15 minutes, 20 ambulant patients (16 male) in sinus rhythm underwent four PWA measurements on a single occasion. Two nurses (A & B) independently and alternately undertook PWA measurements using the same equipment (Omron HEM-757; SphygmoCor with Millar hand-held tonometer) blind to the other nurse's PWA measurements. Within- and between-observer differences were analysed using the Bland-Altman 'limits of agreement' approach (mean difference +/- 2 standard deviations, 2SD). Mean age was 56 (blood pressure, BP 136/79; pulse rate 64). BP/PWA measurements remained stable during assessment. Based on the average of two PWA measurements the mean 2SD between-observer difference in ED% was 0.3 +/- 2.0; AIX@75 1.0 +/- 3.9; and SEVR% 1.7 +/- 14.2. Based on a single PWA measurement the between-observer difference was ED% 0.3 +/- 3.3; AIX@75 1.7 +/- 6.9; and SEVR% 0.6 +/- 22.6. Within-observer differences for nurse-A were ED% 0.0 +/- 5.4; AIX@75 1.5 +/- 7.0; and SEVR% 1.7 +/- 39.0 (nurse-B: 0.1 +/- 3.8; 0.1 +/- 8.0; and 0.6 +/- 23.3, respectively). PWA demonstrates high levels of repeatability even when used by relatively inexperienced staff and has the potential to be included in the routine cardiovascular assessment of ambulant patients.

Original languageEnglish
Pages (from-to)189-197
Number of pages9
JournalVascular Medicine
Volume12
Issue number3
DOIs
Publication statusPublished - Aug 2007

Keywords

  • applanation tonometry
  • measurement error
  • pulse wave analysis
  • radial artery
  • reproducibility
  • arterial stiffness
  • blood-pressure
  • endothelial function
  • augmentation index
  • healthy-subjects
  • aortic pressure
  • renal-failure
  • reflections
  • events

Cite this

Indices of cardiovascular function derived from peripheral pulse wave analysis using radial applanation tonometry : a measurement repeatability study. / Crilly, Mike; Coch, Christoph; Bruce, Margaret; Clark, Hazel; Williams, David.

In: Vascular Medicine, Vol. 12, No. 3, 08.2007, p. 189-197.

Research output: Contribution to journalArticle

@article{34f6646827b94afe8916328da87854db,
title = "Indices of cardiovascular function derived from peripheral pulse wave analysis using radial applanation tonometry: a measurement repeatability study",
abstract = "Pulse wave analysis (PWA) using applanation tonometry is a non-invasive technique for assessing cardiovascular function. It produces three important indices: ejection duration index (ED{\%}), augmentation index adjusted for heart rate (AIX@75), and subendocardial viability ratio (SEVR{\%}). The aim of this study was to assess within- and between-observer repeatability of these measurements. After resting supine for 15 minutes, 20 ambulant patients (16 male) in sinus rhythm underwent four PWA measurements on a single occasion. Two nurses (A & B) independently and alternately undertook PWA measurements using the same equipment (Omron HEM-757; SphygmoCor with Millar hand-held tonometer) blind to the other nurse's PWA measurements. Within- and between-observer differences were analysed using the Bland-Altman 'limits of agreement' approach (mean difference +/- 2 standard deviations, 2SD). Mean age was 56 (blood pressure, BP 136/79; pulse rate 64). BP/PWA measurements remained stable during assessment. Based on the average of two PWA measurements the mean 2SD between-observer difference in ED{\%} was 0.3 +/- 2.0; AIX@75 1.0 +/- 3.9; and SEVR{\%} 1.7 +/- 14.2. Based on a single PWA measurement the between-observer difference was ED{\%} 0.3 +/- 3.3; AIX@75 1.7 +/- 6.9; and SEVR{\%} 0.6 +/- 22.6. Within-observer differences for nurse-A were ED{\%} 0.0 +/- 5.4; AIX@75 1.5 +/- 7.0; and SEVR{\%} 1.7 +/- 39.0 (nurse-B: 0.1 +/- 3.8; 0.1 +/- 8.0; and 0.6 +/- 23.3, respectively). PWA demonstrates high levels of repeatability even when used by relatively inexperienced staff and has the potential to be included in the routine cardiovascular assessment of ambulant patients.",
keywords = "applanation tonometry, measurement error, pulse wave analysis, radial artery, reproducibility, arterial stiffness, blood-pressure, endothelial function, augmentation index, healthy-subjects, aortic pressure, renal-failure, reflections, events",
author = "Mike Crilly and Christoph Coch and Margaret Bruce and Hazel Clark and David Williams",
year = "2007",
month = "8",
doi = "10.1177/1358863x07081134",
language = "English",
volume = "12",
pages = "189--197",
journal = "Vascular Medicine",
issn = "1358-863X",
publisher = "SAGE Publications Ltd",
number = "3",

}

TY - JOUR

T1 - Indices of cardiovascular function derived from peripheral pulse wave analysis using radial applanation tonometry

T2 - a measurement repeatability study

AU - Crilly, Mike

AU - Coch, Christoph

AU - Bruce, Margaret

AU - Clark, Hazel

AU - Williams, David

PY - 2007/8

Y1 - 2007/8

N2 - Pulse wave analysis (PWA) using applanation tonometry is a non-invasive technique for assessing cardiovascular function. It produces three important indices: ejection duration index (ED%), augmentation index adjusted for heart rate (AIX@75), and subendocardial viability ratio (SEVR%). The aim of this study was to assess within- and between-observer repeatability of these measurements. After resting supine for 15 minutes, 20 ambulant patients (16 male) in sinus rhythm underwent four PWA measurements on a single occasion. Two nurses (A & B) independently and alternately undertook PWA measurements using the same equipment (Omron HEM-757; SphygmoCor with Millar hand-held tonometer) blind to the other nurse's PWA measurements. Within- and between-observer differences were analysed using the Bland-Altman 'limits of agreement' approach (mean difference +/- 2 standard deviations, 2SD). Mean age was 56 (blood pressure, BP 136/79; pulse rate 64). BP/PWA measurements remained stable during assessment. Based on the average of two PWA measurements the mean 2SD between-observer difference in ED% was 0.3 +/- 2.0; AIX@75 1.0 +/- 3.9; and SEVR% 1.7 +/- 14.2. Based on a single PWA measurement the between-observer difference was ED% 0.3 +/- 3.3; AIX@75 1.7 +/- 6.9; and SEVR% 0.6 +/- 22.6. Within-observer differences for nurse-A were ED% 0.0 +/- 5.4; AIX@75 1.5 +/- 7.0; and SEVR% 1.7 +/- 39.0 (nurse-B: 0.1 +/- 3.8; 0.1 +/- 8.0; and 0.6 +/- 23.3, respectively). PWA demonstrates high levels of repeatability even when used by relatively inexperienced staff and has the potential to be included in the routine cardiovascular assessment of ambulant patients.

AB - Pulse wave analysis (PWA) using applanation tonometry is a non-invasive technique for assessing cardiovascular function. It produces three important indices: ejection duration index (ED%), augmentation index adjusted for heart rate (AIX@75), and subendocardial viability ratio (SEVR%). The aim of this study was to assess within- and between-observer repeatability of these measurements. After resting supine for 15 minutes, 20 ambulant patients (16 male) in sinus rhythm underwent four PWA measurements on a single occasion. Two nurses (A & B) independently and alternately undertook PWA measurements using the same equipment (Omron HEM-757; SphygmoCor with Millar hand-held tonometer) blind to the other nurse's PWA measurements. Within- and between-observer differences were analysed using the Bland-Altman 'limits of agreement' approach (mean difference +/- 2 standard deviations, 2SD). Mean age was 56 (blood pressure, BP 136/79; pulse rate 64). BP/PWA measurements remained stable during assessment. Based on the average of two PWA measurements the mean 2SD between-observer difference in ED% was 0.3 +/- 2.0; AIX@75 1.0 +/- 3.9; and SEVR% 1.7 +/- 14.2. Based on a single PWA measurement the between-observer difference was ED% 0.3 +/- 3.3; AIX@75 1.7 +/- 6.9; and SEVR% 0.6 +/- 22.6. Within-observer differences for nurse-A were ED% 0.0 +/- 5.4; AIX@75 1.5 +/- 7.0; and SEVR% 1.7 +/- 39.0 (nurse-B: 0.1 +/- 3.8; 0.1 +/- 8.0; and 0.6 +/- 23.3, respectively). PWA demonstrates high levels of repeatability even when used by relatively inexperienced staff and has the potential to be included in the routine cardiovascular assessment of ambulant patients.

KW - applanation tonometry

KW - measurement error

KW - pulse wave analysis

KW - radial artery

KW - reproducibility

KW - arterial stiffness

KW - blood-pressure

KW - endothelial function

KW - augmentation index

KW - healthy-subjects

KW - aortic pressure

KW - renal-failure

KW - reflections

KW - events

U2 - 10.1177/1358863x07081134

DO - 10.1177/1358863x07081134

M3 - Article

VL - 12

SP - 189

EP - 197

JO - Vascular Medicine

JF - Vascular Medicine

SN - 1358-863X

IS - 3

ER -