Individuals With High Bone Mass Have Increased Progression of Radiographic and Clinical Features of Knee Osteoarthritis

April E. Hartley*, Sarah A. Hardcastle, Lavinia Paternoster, Eugene McCloskey, Kenneth E. S. Poole, Muhammad K. Javaid, Mo Aye, Katie Moss, Raquel Granell, Jenny Gregory, Martin Williams, Jon H. Tobias, Celia L. Gregson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)
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Objective: High bone mass (HBM) is associated with an increased prevalence of radiographic knee OA (kOA), characterized by osteophytosis. We aimed to determine if progression of radiographic kOA, and its sub-phenotypes, is increased in HBM and whether observed changes are clinically relevant. Design: A cohort with and without HBM (L1 and/or total hip bone mineral density Z-score>+3.2) had knee radiographs collected at baseline and 8-year follow-up. Sub-phenotypes were graded using the OARSI atlas. Medial/lateral tibial/femoral osteophyte and medial/lateral joint space narrowing (JSN) grades were summed and Δosteophytes, ΔJSN derived. Pain, function and stiffness were quantified using the WOMAC questionnaire. Associations between HBM status and sub-phenotype progression were determined using multivariable linear/poisson regression, adjusting for age, sex, height, baseline sub-phenotype grade, menopause, education and total body fat mass (TBFM). Generalized estimating equations accounted for individual-level clustering. Results: 169 individuals had repeated radiographs, providing 330 knee images; 63% had HBM, 73% were female, mean(SD) age was 58(12) years. Whilst HBM was not clearly associated with overall Kellgren-Lawrence measured progression (RR=1.55[0.56,4.32]), HBM was positively associated with both Δosteophytes and ΔJSN individually (adjusted mean differences between individuals with and without HBM 0.45[0.01,0.89] and 0.15[0.01,0.29], respectively). HBM individuals had higher WOMAC knee pain scores (β=7.42[1.17,13.66]), largely explained by adjustment for osteophyte score (58% attenuated) rather than JSN (30% attenuated) or TBFM (16% attenuated). The same pattern was observed for symptomatic stiffness and functional limitation. Conclusions: HBM is associated with osteophyte progression, which appears to contribute to increased reported pain, stiffness and functional loss.
Original languageEnglish
Pages (from-to)1180-1190
Number of pages11
JournalOsteoarthritis and Cartilage
Issue number9
Early online date14 May 2020
Publication statusPublished - Sep 2020


  • osteoarthritis
  • progression
  • high bone mass
  • BMD
  • health-related quality of life
  • Progression
  • Health-related quality of life
  • High bone mass
  • Osteoarthritis
  • RISK
  • HIP


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