Induction of CD8+ T cell responses through targeting of antigen of Dectin-2

R. W. Carter; C. Thompson; D. M. Reid; Simon Yuk Chun Wong; D. F. Tough

doi:10.1016/j.cellimm.2006.05.001

Induction of CD8+ T cell responses through targeting of antigen of Dectin-2

R. W. Carter, C. Thompson, D. M. Reid, Simon Yuk Chun Wong, D. F. Tough

Applied Medicine

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

Targeted delivery of antigens to dendritic cells (DC) can be used to optimise immunisation. We investigated whether the efficacy with which immune responses are induced can be improved by targeting Ags to a C-type lectin receptor, Dectin-2. When anti-Dectin-2 mAbs were injected s.c., mAb binding was detected on a low percentage of DC in the draining lymph node. Ag conjugated to anti-Dectin-2 mAbs was presented efficiently to CD8(+) T cells in vivo and elicited CD8(+) T cell responses at low doses where free Ag failed to induce a response. The results reveal Dectin-2 as a potential targeting molecule for immunisation. (c) 2006 Elsevier Inc. All rights reserved.

Original language	English
Pages (from-to)	87-91
Number of pages	4
Journal	Cellular Immunology
Volume	239
DOIs	https://doi.org/10.1016/j.cellimm.2006.05.001
Publication status	Published - 2006

Keywords

dendritic cells
Dectin-2
vaccination
CD8(+) T cells
C-type lectin receptor
BETA-GLUCAN RECEPTOR
DENDRITIC CELLS
IN-VIVO
EXPRESSION
TOLERANCE
MOLECULES
DELIVERY
IMMUNITY
GENE
MHC

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.cellimm.2006.05.001

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title = "Induction of CD8+ T cell responses through targeting of antigen of Dectin-2",

abstract = "Targeted delivery of antigens to dendritic cells (DC) can be used to optimise immunisation. We investigated whether the efficacy with which immune responses are induced can be improved by targeting Ags to a C-type lectin receptor, Dectin-2. When anti-Dectin-2 mAbs were injected s.c., mAb binding was detected on a low percentage of DC in the draining lymph node. Ag conjugated to anti-Dectin-2 mAbs was presented efficiently to CD8(+) T cells in vivo and elicited CD8(+) T cell responses at low doses where free Ag failed to induce a response. The results reveal Dectin-2 as a potential targeting molecule for immunisation. (c) 2006 Elsevier Inc. All rights reserved.",

keywords = "dendritic cells, Dectin-2, vaccination, CD8(+) T cells, C-type lectin receptor, BETA-GLUCAN RECEPTOR, DENDRITIC CELLS, IN-VIVO, EXPRESSION, TOLERANCE, MOLECULES, DELIVERY, IMMUNITY, GENE, MHC",

author = "Carter, {R. W.} and C. Thompson and Reid, {D. M.} and Wong, {Simon Yuk Chun} and Tough, {D. F.}",

year = "2006",

doi = "10.1016/j.cellimm.2006.05.001",

language = "English",

volume = "239",

pages = "87--91",

journal = "Cellular Immunology",

issn = "0008-8749",

publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - Induction of CD8+ T cell responses through targeting of antigen of Dectin-2

AU - Carter, R. W.

AU - Thompson, C.

AU - Reid, D. M.

AU - Wong, Simon Yuk Chun

AU - Tough, D. F.

PY - 2006

Y1 - 2006

N2 - Targeted delivery of antigens to dendritic cells (DC) can be used to optimise immunisation. We investigated whether the efficacy with which immune responses are induced can be improved by targeting Ags to a C-type lectin receptor, Dectin-2. When anti-Dectin-2 mAbs were injected s.c., mAb binding was detected on a low percentage of DC in the draining lymph node. Ag conjugated to anti-Dectin-2 mAbs was presented efficiently to CD8(+) T cells in vivo and elicited CD8(+) T cell responses at low doses where free Ag failed to induce a response. The results reveal Dectin-2 as a potential targeting molecule for immunisation. (c) 2006 Elsevier Inc. All rights reserved.

AB - Targeted delivery of antigens to dendritic cells (DC) can be used to optimise immunisation. We investigated whether the efficacy with which immune responses are induced can be improved by targeting Ags to a C-type lectin receptor, Dectin-2. When anti-Dectin-2 mAbs were injected s.c., mAb binding was detected on a low percentage of DC in the draining lymph node. Ag conjugated to anti-Dectin-2 mAbs was presented efficiently to CD8(+) T cells in vivo and elicited CD8(+) T cell responses at low doses where free Ag failed to induce a response. The results reveal Dectin-2 as a potential targeting molecule for immunisation. (c) 2006 Elsevier Inc. All rights reserved.

KW - dendritic cells

KW - Dectin-2

KW - vaccination

KW - CD8(+) T cells

KW - C-type lectin receptor

KW - BETA-GLUCAN RECEPTOR

KW - DENDRITIC CELLS

KW - IN-VIVO

KW - EXPRESSION

KW - TOLERANCE

KW - MOLECULES

KW - DELIVERY

KW - IMMUNITY

KW - GENE

KW - MHC

U2 - 10.1016/j.cellimm.2006.05.001

DO - 10.1016/j.cellimm.2006.05.001

M3 - Article

VL - 239

SP - 87

EP - 91

JO - Cellular Immunology

JF - Cellular Immunology

SN - 0008-8749

ER -

Induction of CD8+ T cell responses through targeting of antigen of Dectin-2

Abstract

Keywords

UN SDGs

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