Induction of protective immunity against cryptococcosis

Karen L. Wozniak, Sarah Hardison, Michal Olszewski, Floyd L. Wormley

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Cryptococcus neoformans, the predominant etiological agent of cryptococcosis, is an encapsulated fungal pathogen that can cause life-threatening infections of the central nervous system in immune compromised individuals resulting in high morbidity and mortality. Consequently, several studies have endeavored to understand those mechanisms that mediate resistance and susceptibility to Cryptococcus infection. In this review, we will examine the contributions of various components of the innate and adaptive immune response toward protection against cryptococcosis. We will focus our discussion on studies presented at the 8th International Conference on Cryptococcus and Cryptococcosis (ICCC). Remarkable progress has been made toward our understanding of host immunity and susceptibility to cryptococcal infection and the potential for vaccine development.

Original languageEnglish
Pages (from-to)387-394
Number of pages8
JournalMycopathologia
Volume173
Issue number5-6
Early online date6 Dec 2011
DOIs
Publication statusPublished - 1 Jun 2012

Keywords

  • cryptococcosis
  • cryptococcus
  • Cryptococcus neoformans
  • fungal immunology
  • fungal pathogenesis
  • protective immunity

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    Wozniak, K. L., Hardison, S., Olszewski, M., & Wormley, F. L. (2012). Induction of protective immunity against cryptococcosis. Mycopathologia, 173(5-6), 387-394. https://doi.org/10.1007/s11046-011-9505-8