Infant arterial stiffness and maternal iron status in pregnancy

a UK birth cohort (Baby VIP study)

Nisreen A Alwan, Janet E Cade, Harry J McArdle, Darren C Greenwood, Helen E Hayes, Etienne Ciantar, Nigel A B Simpson

Research output: Contribution to journalArticle

1 Citation (Scopus)
5 Downloads (Pure)

Abstract

BACKGROUND: In animal studies, iron deficiency during pregnancy has been linked to increased offspring cardiovascular risk. No previous population studies have measured arterial stiffness early in life to examine its association with maternal iron status.

OBJECTIVE: This study aimed to examine the association between maternal iron status in early pregnancy with infant brachio-femoral pulse wave velocity (PWV).

METHODS: The Baby VIP (Baby's Vascular Health and Iron in Pregnancy) study is a UK-based birth cohort which recruited 362 women after delivery from the Leeds Teaching Hospitals postnatal wards. Ferritin and transferrin receptor levels were measured in maternal serum samples previously obtained in the first trimester. Infant brachio-femoral PWV was measured during a home visit at 2-6 weeks.

RESULTS: Iron depletion (ferritin <15 μg/l) was detected in 79 (23%) women in early pregnancy. Infant PWV (mean = 6.7 m/s, SD = 1.3, n = 284) was neither associated with maternal ferritin (adjusted change per 10 μg/l = 0.02, 95% CI: -0.01, 0.1), nor with iron depletion (adjusted change = -0.2, 95% CI: -0.6, 0.2). No evidence of association was observed between maternal serum transferrin receptor level and its ratio to ferritin with infant PWV. Maternal anaemia (<11 g/dl) at ≤20 weeks' gestation was associated with a 1.0-m/s increase in infant PWV (adjusted 95% CI: 0.1, 1.9).

CONCLUSION: This is the largest study to date which has assessed peripheral PWV as a measure of arterial stiffness in infants. There was no evidence of an association between markers of maternal iron status early in pregnancy and infant PWV. © 2015 S. Karger AG, Basel.

Original languageEnglish
Pages (from-to)297-303
Number of pages7
JournalNeonatology
Volume107
Issue number4
Early online date12 Mar 2015
DOIs
Publication statusPublished - Jun 2015

Fingerprint

Pulse Wave Analysis
Vascular Stiffness
Iron
Mothers
Parturition
Pregnancy
Ferritins
Transferrin Receptors
Thigh
House Calls
First Pregnancy Trimester
Serum
Teaching Hospitals
Blood Vessels
Anemia
Population

Keywords

  • vascular stiffness
  • iron
  • pregnancy
  • infant
  • micronutrients
  • anaemia

Cite this

Alwan, N. A., Cade, J. E., McArdle, H. J., Greenwood, D. C., Hayes, H. E., Ciantar, E., & Simpson, N. A. B. (2015). Infant arterial stiffness and maternal iron status in pregnancy: a UK birth cohort (Baby VIP study). Neonatology, 107(4), 297-303. https://doi.org/10.1159/000377618

Infant arterial stiffness and maternal iron status in pregnancy : a UK birth cohort (Baby VIP study). / Alwan, Nisreen A; Cade, Janet E; McArdle, Harry J; Greenwood, Darren C; Hayes, Helen E; Ciantar, Etienne; Simpson, Nigel A B.

In: Neonatology, Vol. 107, No. 4, 06.2015, p. 297-303.

Research output: Contribution to journalArticle

Alwan, NA, Cade, JE, McArdle, HJ, Greenwood, DC, Hayes, HE, Ciantar, E & Simpson, NAB 2015, 'Infant arterial stiffness and maternal iron status in pregnancy: a UK birth cohort (Baby VIP study)', Neonatology, vol. 107, no. 4, pp. 297-303. https://doi.org/10.1159/000377618
Alwan, Nisreen A ; Cade, Janet E ; McArdle, Harry J ; Greenwood, Darren C ; Hayes, Helen E ; Ciantar, Etienne ; Simpson, Nigel A B. / Infant arterial stiffness and maternal iron status in pregnancy : a UK birth cohort (Baby VIP study). In: Neonatology. 2015 ; Vol. 107, No. 4. pp. 297-303.
@article{597efb055919480f86b472b009a6bb98,
title = "Infant arterial stiffness and maternal iron status in pregnancy: a UK birth cohort (Baby VIP study)",
abstract = "BACKGROUND: In animal studies, iron deficiency during pregnancy has been linked to increased offspring cardiovascular risk. No previous population studies have measured arterial stiffness early in life to examine its association with maternal iron status.OBJECTIVE: This study aimed to examine the association between maternal iron status in early pregnancy with infant brachio-femoral pulse wave velocity (PWV).METHODS: The Baby VIP (Baby's Vascular Health and Iron in Pregnancy) study is a UK-based birth cohort which recruited 362 women after delivery from the Leeds Teaching Hospitals postnatal wards. Ferritin and transferrin receptor levels were measured in maternal serum samples previously obtained in the first trimester. Infant brachio-femoral PWV was measured during a home visit at 2-6 weeks.RESULTS: Iron depletion (ferritin <15 μg/l) was detected in 79 (23{\%}) women in early pregnancy. Infant PWV (mean = 6.7 m/s, SD = 1.3, n = 284) was neither associated with maternal ferritin (adjusted change per 10 μg/l = 0.02, 95{\%} CI: -0.01, 0.1), nor with iron depletion (adjusted change = -0.2, 95{\%} CI: -0.6, 0.2). No evidence of association was observed between maternal serum transferrin receptor level and its ratio to ferritin with infant PWV. Maternal anaemia (<11 g/dl) at ≤20 weeks' gestation was associated with a 1.0-m/s increase in infant PWV (adjusted 95{\%} CI: 0.1, 1.9).CONCLUSION: This is the largest study to date which has assessed peripheral PWV as a measure of arterial stiffness in infants. There was no evidence of an association between markers of maternal iron status early in pregnancy and infant PWV. {\circledC} 2015 S. Karger AG, Basel.",
keywords = "vascular stiffness, iron, pregnancy, infant, micronutrients, anaemia",
author = "Alwan, {Nisreen A} and Cade, {Janet E} and McArdle, {Harry J} and Greenwood, {Darren C} and Hayes, {Helen E} and Etienne Ciantar and Simpson, {Nigel A B}",
note = "Acknowledgements We are sincerely grateful to all study participants. Our thanks go to Angela Wray, Julie Grindey and Viv Dolby for data collection; Antony Hales, Russel Booth, Ruth Owen and Christine Kennedy for facilitating laboratory analysis, and Stephen Greenwald for advice on PWV measurement. Source of funding: N.A.A. is funded by a Wellcome Trust Research Training Fellowship (WT87789). H.J.M. and H.E.H. are supported by the Scottish Government Rural and Environmental Services (RESAS). N.A.B.S. is supported by Cerebra.",
year = "2015",
month = "6",
doi = "10.1159/000377618",
language = "English",
volume = "107",
pages = "297--303",
journal = "Neonatology",
issn = "1661-7800",
publisher = "S. Karger AG",
number = "4",

}

TY - JOUR

T1 - Infant arterial stiffness and maternal iron status in pregnancy

T2 - a UK birth cohort (Baby VIP study)

AU - Alwan, Nisreen A

AU - Cade, Janet E

AU - McArdle, Harry J

AU - Greenwood, Darren C

AU - Hayes, Helen E

AU - Ciantar, Etienne

AU - Simpson, Nigel A B

N1 - Acknowledgements We are sincerely grateful to all study participants. Our thanks go to Angela Wray, Julie Grindey and Viv Dolby for data collection; Antony Hales, Russel Booth, Ruth Owen and Christine Kennedy for facilitating laboratory analysis, and Stephen Greenwald for advice on PWV measurement. Source of funding: N.A.A. is funded by a Wellcome Trust Research Training Fellowship (WT87789). H.J.M. and H.E.H. are supported by the Scottish Government Rural and Environmental Services (RESAS). N.A.B.S. is supported by Cerebra.

PY - 2015/6

Y1 - 2015/6

N2 - BACKGROUND: In animal studies, iron deficiency during pregnancy has been linked to increased offspring cardiovascular risk. No previous population studies have measured arterial stiffness early in life to examine its association with maternal iron status.OBJECTIVE: This study aimed to examine the association between maternal iron status in early pregnancy with infant brachio-femoral pulse wave velocity (PWV).METHODS: The Baby VIP (Baby's Vascular Health and Iron in Pregnancy) study is a UK-based birth cohort which recruited 362 women after delivery from the Leeds Teaching Hospitals postnatal wards. Ferritin and transferrin receptor levels were measured in maternal serum samples previously obtained in the first trimester. Infant brachio-femoral PWV was measured during a home visit at 2-6 weeks.RESULTS: Iron depletion (ferritin <15 μg/l) was detected in 79 (23%) women in early pregnancy. Infant PWV (mean = 6.7 m/s, SD = 1.3, n = 284) was neither associated with maternal ferritin (adjusted change per 10 μg/l = 0.02, 95% CI: -0.01, 0.1), nor with iron depletion (adjusted change = -0.2, 95% CI: -0.6, 0.2). No evidence of association was observed between maternal serum transferrin receptor level and its ratio to ferritin with infant PWV. Maternal anaemia (<11 g/dl) at ≤20 weeks' gestation was associated with a 1.0-m/s increase in infant PWV (adjusted 95% CI: 0.1, 1.9).CONCLUSION: This is the largest study to date which has assessed peripheral PWV as a measure of arterial stiffness in infants. There was no evidence of an association between markers of maternal iron status early in pregnancy and infant PWV. © 2015 S. Karger AG, Basel.

AB - BACKGROUND: In animal studies, iron deficiency during pregnancy has been linked to increased offspring cardiovascular risk. No previous population studies have measured arterial stiffness early in life to examine its association with maternal iron status.OBJECTIVE: This study aimed to examine the association between maternal iron status in early pregnancy with infant brachio-femoral pulse wave velocity (PWV).METHODS: The Baby VIP (Baby's Vascular Health and Iron in Pregnancy) study is a UK-based birth cohort which recruited 362 women after delivery from the Leeds Teaching Hospitals postnatal wards. Ferritin and transferrin receptor levels were measured in maternal serum samples previously obtained in the first trimester. Infant brachio-femoral PWV was measured during a home visit at 2-6 weeks.RESULTS: Iron depletion (ferritin <15 μg/l) was detected in 79 (23%) women in early pregnancy. Infant PWV (mean = 6.7 m/s, SD = 1.3, n = 284) was neither associated with maternal ferritin (adjusted change per 10 μg/l = 0.02, 95% CI: -0.01, 0.1), nor with iron depletion (adjusted change = -0.2, 95% CI: -0.6, 0.2). No evidence of association was observed between maternal serum transferrin receptor level and its ratio to ferritin with infant PWV. Maternal anaemia (<11 g/dl) at ≤20 weeks' gestation was associated with a 1.0-m/s increase in infant PWV (adjusted 95% CI: 0.1, 1.9).CONCLUSION: This is the largest study to date which has assessed peripheral PWV as a measure of arterial stiffness in infants. There was no evidence of an association between markers of maternal iron status early in pregnancy and infant PWV. © 2015 S. Karger AG, Basel.

KW - vascular stiffness

KW - iron

KW - pregnancy

KW - infant

KW - micronutrients

KW - anaemia

U2 - 10.1159/000377618

DO - 10.1159/000377618

M3 - Article

VL - 107

SP - 297

EP - 303

JO - Neonatology

JF - Neonatology

SN - 1661-7800

IS - 4

ER -