Infertility and miscarriage: common pathways in manifestation and management

Angena Agenor, Sohinee Bhattacharya

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The relationship between miscarriage and fertility is complex. While most healthcare settings treat miscarriage as a problem of subfertility in assisted reproduction units, others believe that miscarriage occurs in super-fertile women. Infertile women undergoing assisted reproduction are at a greater risk of having a miscarriage especially at an advanced age compared with women conceiving naturally. Aberrant expression of immunological factors and chromosomal abnormalities underlie both infertility and miscarriage. Common risk factors include increased maternal age, obesity, smoking, alcohol, pre-existing medical conditions and anatomical abnormalities of the reproductive system. Management pathways of both conditions may be similar with pre-implantation genetic testing and assisted reproductive technology used in both conditions. This paper discusses the synergies and differences between the two conditions in terms of their epidemiology, etiopathogenesis, risk factors and management strategies. The two conditions are related as degrees of severity of reproductive failure with common pathways in manifestation and management.

Original languageEnglish
Pages (from-to)527-541
Number of pages15
JournalWomen's Health
Volume11
Issue number4
DOIs
Publication statusPublished - 4 Aug 2015

Fingerprint

Spontaneous Abortion
Infertility
Reproduction
Assisted Reproductive Techniques
Preexisting Condition Coverage
Maternal Age
Risk Management
Immunologic Factors
Genetic Testing
Chromosome Aberrations
Fertility
Epidemiology
Obesity
Smoking
Alcohols
Delivery of Health Care

Keywords

  • advanced maternal age
  • assisted reproductive technology
  • infertility
  • miscarriage
  • recurrent miscarriage
  • spontaneous abortion
  • subfertility

Cite this

Infertility and miscarriage : common pathways in manifestation and management. / Agenor, Angena; Bhattacharya, Sohinee.

In: Women's Health, Vol. 11, No. 4, 04.08.2015, p. 527-541.

Research output: Contribution to journalArticle

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