Inflammatory choroidal neovascular membrane in presumed ocular Lyme borreliosis

Radgonde Amer, Suzanne Brannan, John Vincent Forrester

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Lyme disease is a multisystemic disease with protean ocular manifestations. We describe the occurrence of inflammatory choroidal neovascular membrane (CNVM) in two patients suffering from presumed Lyme disease.

Descriptive review of the clinical records of two patients.

Patient 1: 16-year-old healthy male presenting with a visual acuity of counting fingers [oculus dexter (OD)] and 6/6 [oculus sinister (OS)] 3 months after a tick bite. He had papillitis and an exudative subretinal macular lesion OD. Treatment was started with intravenous (IV) ceftriaxone; a week later, IV methylprednisolone was administered with a tapering dose of oral steroids thereafter. Three months later, VA had improved to 3/60 OD. Patient 2: 38-year-old healthy female presenting with reduced left-eye vision (6/24) 6 weeks after a tick bite. She also suffered from erythema migrans and arthralgias. She had left-eye papillitis, macular haemorrhages and vascular sheathing. Treatment was started with IV ceftriaxone. One month later, there was profound loss of vision with development of CNVM. Treatment was declined by the patient and eventually retinal fibrosis developed.

Inflammatory CNVM has not been described previously in the setting of ocular Lyme borreliosis. We herein describe the occurrence of inflammatory CNVM in two patients whose diagnosis with Lyme disease was clinically based - both were sero-negative. Visual outcome in the two patients was profoundly impaired because of the ensuing macular scar.

Original languageEnglish
Pages (from-to)346-348
Number of pages3
JournalActa Ophthalmologica
Volume87
Issue number3
Early online date28 Jun 2008
DOIs
Publication statusPublished - May 2009

Keywords

  • choroidal neovascular membrane
  • Lyme disease
  • maculopathy
  • uveitis
  • Burgdorferi
  • disease

Cite this

Inflammatory choroidal neovascular membrane in presumed ocular Lyme borreliosis. / Amer, Radgonde; Brannan, Suzanne; Forrester, John Vincent.

In: Acta Ophthalmologica, Vol. 87, No. 3, 05.2009, p. 346-348.

Research output: Contribution to journalArticle

Amer, Radgonde ; Brannan, Suzanne ; Forrester, John Vincent. / Inflammatory choroidal neovascular membrane in presumed ocular Lyme borreliosis. In: Acta Ophthalmologica. 2009 ; Vol. 87, No. 3. pp. 346-348.
@article{360bf05160b14eb38f62185ded9c5084,
title = "Inflammatory choroidal neovascular membrane in presumed ocular Lyme borreliosis",
abstract = "Lyme disease is a multisystemic disease with protean ocular manifestations. We describe the occurrence of inflammatory choroidal neovascular membrane (CNVM) in two patients suffering from presumed Lyme disease.Descriptive review of the clinical records of two patients.Patient 1: 16-year-old healthy male presenting with a visual acuity of counting fingers [oculus dexter (OD)] and 6/6 [oculus sinister (OS)] 3 months after a tick bite. He had papillitis and an exudative subretinal macular lesion OD. Treatment was started with intravenous (IV) ceftriaxone; a week later, IV methylprednisolone was administered with a tapering dose of oral steroids thereafter. Three months later, VA had improved to 3/60 OD. Patient 2: 38-year-old healthy female presenting with reduced left-eye vision (6/24) 6 weeks after a tick bite. She also suffered from erythema migrans and arthralgias. She had left-eye papillitis, macular haemorrhages and vascular sheathing. Treatment was started with IV ceftriaxone. One month later, there was profound loss of vision with development of CNVM. Treatment was declined by the patient and eventually retinal fibrosis developed.Inflammatory CNVM has not been described previously in the setting of ocular Lyme borreliosis. We herein describe the occurrence of inflammatory CNVM in two patients whose diagnosis with Lyme disease was clinically based - both were sero-negative. Visual outcome in the two patients was profoundly impaired because of the ensuing macular scar.",
keywords = "choroidal neovascular membrane, Lyme disease, maculopathy, uveitis, Burgdorferi , disease",
author = "Radgonde Amer and Suzanne Brannan and Forrester, {John Vincent}",
year = "2009",
month = "5",
doi = "10.1111/j.1755-3768.2007.01160.x",
language = "English",
volume = "87",
pages = "346--348",
journal = "Acta Ophthalmologica",
issn = "1755-375X",
publisher = "Wiley-Blackwell",
number = "3",

}

TY - JOUR

T1 - Inflammatory choroidal neovascular membrane in presumed ocular Lyme borreliosis

AU - Amer, Radgonde

AU - Brannan, Suzanne

AU - Forrester, John Vincent

PY - 2009/5

Y1 - 2009/5

N2 - Lyme disease is a multisystemic disease with protean ocular manifestations. We describe the occurrence of inflammatory choroidal neovascular membrane (CNVM) in two patients suffering from presumed Lyme disease.Descriptive review of the clinical records of two patients.Patient 1: 16-year-old healthy male presenting with a visual acuity of counting fingers [oculus dexter (OD)] and 6/6 [oculus sinister (OS)] 3 months after a tick bite. He had papillitis and an exudative subretinal macular lesion OD. Treatment was started with intravenous (IV) ceftriaxone; a week later, IV methylprednisolone was administered with a tapering dose of oral steroids thereafter. Three months later, VA had improved to 3/60 OD. Patient 2: 38-year-old healthy female presenting with reduced left-eye vision (6/24) 6 weeks after a tick bite. She also suffered from erythema migrans and arthralgias. She had left-eye papillitis, macular haemorrhages and vascular sheathing. Treatment was started with IV ceftriaxone. One month later, there was profound loss of vision with development of CNVM. Treatment was declined by the patient and eventually retinal fibrosis developed.Inflammatory CNVM has not been described previously in the setting of ocular Lyme borreliosis. We herein describe the occurrence of inflammatory CNVM in two patients whose diagnosis with Lyme disease was clinically based - both were sero-negative. Visual outcome in the two patients was profoundly impaired because of the ensuing macular scar.

AB - Lyme disease is a multisystemic disease with protean ocular manifestations. We describe the occurrence of inflammatory choroidal neovascular membrane (CNVM) in two patients suffering from presumed Lyme disease.Descriptive review of the clinical records of two patients.Patient 1: 16-year-old healthy male presenting with a visual acuity of counting fingers [oculus dexter (OD)] and 6/6 [oculus sinister (OS)] 3 months after a tick bite. He had papillitis and an exudative subretinal macular lesion OD. Treatment was started with intravenous (IV) ceftriaxone; a week later, IV methylprednisolone was administered with a tapering dose of oral steroids thereafter. Three months later, VA had improved to 3/60 OD. Patient 2: 38-year-old healthy female presenting with reduced left-eye vision (6/24) 6 weeks after a tick bite. She also suffered from erythema migrans and arthralgias. She had left-eye papillitis, macular haemorrhages and vascular sheathing. Treatment was started with IV ceftriaxone. One month later, there was profound loss of vision with development of CNVM. Treatment was declined by the patient and eventually retinal fibrosis developed.Inflammatory CNVM has not been described previously in the setting of ocular Lyme borreliosis. We herein describe the occurrence of inflammatory CNVM in two patients whose diagnosis with Lyme disease was clinically based - both were sero-negative. Visual outcome in the two patients was profoundly impaired because of the ensuing macular scar.

KW - choroidal neovascular membrane

KW - Lyme disease

KW - maculopathy

KW - uveitis

KW - Burgdorferi

KW - disease

U2 - 10.1111/j.1755-3768.2007.01160.x

DO - 10.1111/j.1755-3768.2007.01160.x

M3 - Article

VL - 87

SP - 346

EP - 348

JO - Acta Ophthalmologica

JF - Acta Ophthalmologica

SN - 1755-375X

IS - 3

ER -