Influence of age on antisecretory factor inhibition of enterotoxin action in the pig small intestine

G T McEwan, B Schousboe, E Skadhauge

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The effect of age on antisecretory factor (ASF) inhibition of cholera toxin (CT) and E. coli STa enterotoxin-induced fluid secretion in pig jejunum was investigated in vivo. Comparison was made between 2 week and 8 week old animals. ASF inhibited (P less than 0.05) CT-induced fluid secretion by up to 90% in the 8 week animals (from 18.4 +/- 5.87 mg/mg loop dry weight to 0.74 +/- 0.54 mg/mg loop dry weight). There was no effect of ASF on CT-secretion in the 14 day pigs suggesting that there is a minimum age before ASF is effective. ASF had no significant effect on net fluid transport after STa challenge in pigs from either age group. However, the predominant action of STa was to inhibit absorption and this would not be affected by ASF.
Original languageEnglish
Pages (from-to)222-8
Number of pages7
JournalZentralblatt für Veterinärmedizin. Reihe A
Volume38
Issue number3
Publication statusPublished - Apr 1991

Fingerprint

cholera toxin
Enterotoxins
enterotoxins
Small Intestine
small intestine
Swine
secretion
swine
Cholera Toxin
Fluids and Secretions
jejunum
Escherichia coli
Weights and Measures
Jejunum
fluids
antisecretory factor
animals
Age Groups

Keywords

  • Aging
  • Animals
  • Antidiarrheals
  • Bacterial Toxins
  • Cholera Toxin
  • Enterotoxins
  • Escherichia coli Proteins
  • Intestine, Small
  • Neuropeptides
  • Swine

Cite this

Influence of age on antisecretory factor inhibition of enterotoxin action in the pig small intestine. / McEwan, G T; Schousboe, B; Skadhauge, E.

In: Zentralblatt für Veterinärmedizin. Reihe A, Vol. 38, No. 3, 04.1991, p. 222-8.

Research output: Contribution to journalArticle

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AB - The effect of age on antisecretory factor (ASF) inhibition of cholera toxin (CT) and E. coli STa enterotoxin-induced fluid secretion in pig jejunum was investigated in vivo. Comparison was made between 2 week and 8 week old animals. ASF inhibited (P less than 0.05) CT-induced fluid secretion by up to 90% in the 8 week animals (from 18.4 +/- 5.87 mg/mg loop dry weight to 0.74 +/- 0.54 mg/mg loop dry weight). There was no effect of ASF on CT-secretion in the 14 day pigs suggesting that there is a minimum age before ASF is effective. ASF had no significant effect on net fluid transport after STa challenge in pigs from either age group. However, the predominant action of STa was to inhibit absorption and this would not be affected by ASF.

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KW - Neuropeptides

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