Influence of Antiidiotypic Antibody-Activity on Renal-Transplant Outcome

I A ALMUZAIRAI, R DOLHAIN, Y TAYLOR, Keith Nicol Stewart, M MACMILLAN, G R D CATTO, A M MACLEOD

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The presence of cytotoxic HLA antibodies (Ab1) against donor lymphocytes in pretransplant sera is almost always associated with rapid rejection of the renal transplant. We have investigated the possibility that antiidiotypic antibodies (Ab2) to cytotoxic HLA antibodies might modulate the immune response and favorably influence renal allograft outcome. The role of antibodies (Ab3) which potentiate the cytotoxic effect of Ab1 was also studied. Pretransplant sera from 63 patients were tested for inhibitory or potentiating activity in the short antiidiotypic assay. Inhibitory activity was detected in 30 patients and in 28 the transplant survived more than a year. Of patients without antibody activity 11 of 17 had grafts surviving more than one year, and of those showing potentiating activity 11 of 16 were functioning at a year. The difference in transplant survival between the first group and the other two groups was statistically significant (P < 0.05). There was no significant difference in survival rates between the latter two groups. Potentiating activity is therefore not an independent predictor of transplant failure, whereas the presence of antiidiotypic antibody activity did correlate with improved allograft survival.

Original languageEnglish
Pages (from-to)80-85
Number of pages6
JournalKidney International
Volume40
Issue number1
Publication statusPublished - Jul 1991

Keywords

  • DONOR-SPECIFIC TRANSFUSION
  • BLOOD-TRANSFUSIONS
  • SUPPRESSOR CELLS
  • GRAFT-SURVIVAL
  • CYCLOSPORINE-A
  • RECIPIENTS
  • KIDNEY
  • HLA
  • ALLOANTIBODIES
  • PREGNANCY

Cite this

ALMUZAIRAI, I. A., DOLHAIN, R., TAYLOR, Y., Stewart, K. N., MACMILLAN, M., CATTO, G. R. D., & MACLEOD, A. M. (1991). Influence of Antiidiotypic Antibody-Activity on Renal-Transplant Outcome. Kidney International, 40(1), 80-85.

Influence of Antiidiotypic Antibody-Activity on Renal-Transplant Outcome. / ALMUZAIRAI, I A ; DOLHAIN, R ; TAYLOR, Y ; Stewart, Keith Nicol; MACMILLAN, M ; CATTO, G R D ; MACLEOD, A M .

In: Kidney International, Vol. 40, No. 1, 07.1991, p. 80-85.

Research output: Contribution to journalArticle

ALMUZAIRAI, IA, DOLHAIN, R, TAYLOR, Y, Stewart, KN, MACMILLAN, M, CATTO, GRD & MACLEOD, AM 1991, 'Influence of Antiidiotypic Antibody-Activity on Renal-Transplant Outcome', Kidney International, vol. 40, no. 1, pp. 80-85.
ALMUZAIRAI IA, DOLHAIN R, TAYLOR Y, Stewart KN, MACMILLAN M, CATTO GRD et al. Influence of Antiidiotypic Antibody-Activity on Renal-Transplant Outcome. Kidney International. 1991 Jul;40(1):80-85.
ALMUZAIRAI, I A ; DOLHAIN, R ; TAYLOR, Y ; Stewart, Keith Nicol ; MACMILLAN, M ; CATTO, G R D ; MACLEOD, A M . / Influence of Antiidiotypic Antibody-Activity on Renal-Transplant Outcome. In: Kidney International. 1991 ; Vol. 40, No. 1. pp. 80-85.
@article{2a04ecc149a84f7a8180fd89046c0560,
title = "Influence of Antiidiotypic Antibody-Activity on Renal-Transplant Outcome",
abstract = "The presence of cytotoxic HLA antibodies (Ab1) against donor lymphocytes in pretransplant sera is almost always associated with rapid rejection of the renal transplant. We have investigated the possibility that antiidiotypic antibodies (Ab2) to cytotoxic HLA antibodies might modulate the immune response and favorably influence renal allograft outcome. The role of antibodies (Ab3) which potentiate the cytotoxic effect of Ab1 was also studied. Pretransplant sera from 63 patients were tested for inhibitory or potentiating activity in the short antiidiotypic assay. Inhibitory activity was detected in 30 patients and in 28 the transplant survived more than a year. Of patients without antibody activity 11 of 17 had grafts surviving more than one year, and of those showing potentiating activity 11 of 16 were functioning at a year. The difference in transplant survival between the first group and the other two groups was statistically significant (P < 0.05). There was no significant difference in survival rates between the latter two groups. Potentiating activity is therefore not an independent predictor of transplant failure, whereas the presence of antiidiotypic antibody activity did correlate with improved allograft survival.",
keywords = "DONOR-SPECIFIC TRANSFUSION, BLOOD-TRANSFUSIONS, SUPPRESSOR CELLS, GRAFT-SURVIVAL, CYCLOSPORINE-A, RECIPIENTS, KIDNEY, HLA, ALLOANTIBODIES, PREGNANCY",
author = "ALMUZAIRAI, {I A} and R DOLHAIN and Y TAYLOR and Stewart, {Keith Nicol} and M MACMILLAN and CATTO, {G R D} and MACLEOD, {A M}",
year = "1991",
month = "7",
language = "English",
volume = "40",
pages = "80--85",
journal = "Kidney International",
issn = "0085-2538",
publisher = "Nature Publishing Group",
number = "1",

}

TY - JOUR

T1 - Influence of Antiidiotypic Antibody-Activity on Renal-Transplant Outcome

AU - ALMUZAIRAI, I A

AU - DOLHAIN, R

AU - TAYLOR, Y

AU - Stewart, Keith Nicol

AU - MACMILLAN, M

AU - CATTO, G R D

AU - MACLEOD, A M

PY - 1991/7

Y1 - 1991/7

N2 - The presence of cytotoxic HLA antibodies (Ab1) against donor lymphocytes in pretransplant sera is almost always associated with rapid rejection of the renal transplant. We have investigated the possibility that antiidiotypic antibodies (Ab2) to cytotoxic HLA antibodies might modulate the immune response and favorably influence renal allograft outcome. The role of antibodies (Ab3) which potentiate the cytotoxic effect of Ab1 was also studied. Pretransplant sera from 63 patients were tested for inhibitory or potentiating activity in the short antiidiotypic assay. Inhibitory activity was detected in 30 patients and in 28 the transplant survived more than a year. Of patients without antibody activity 11 of 17 had grafts surviving more than one year, and of those showing potentiating activity 11 of 16 were functioning at a year. The difference in transplant survival between the first group and the other two groups was statistically significant (P < 0.05). There was no significant difference in survival rates between the latter two groups. Potentiating activity is therefore not an independent predictor of transplant failure, whereas the presence of antiidiotypic antibody activity did correlate with improved allograft survival.

AB - The presence of cytotoxic HLA antibodies (Ab1) against donor lymphocytes in pretransplant sera is almost always associated with rapid rejection of the renal transplant. We have investigated the possibility that antiidiotypic antibodies (Ab2) to cytotoxic HLA antibodies might modulate the immune response and favorably influence renal allograft outcome. The role of antibodies (Ab3) which potentiate the cytotoxic effect of Ab1 was also studied. Pretransplant sera from 63 patients were tested for inhibitory or potentiating activity in the short antiidiotypic assay. Inhibitory activity was detected in 30 patients and in 28 the transplant survived more than a year. Of patients without antibody activity 11 of 17 had grafts surviving more than one year, and of those showing potentiating activity 11 of 16 were functioning at a year. The difference in transplant survival between the first group and the other two groups was statistically significant (P < 0.05). There was no significant difference in survival rates between the latter two groups. Potentiating activity is therefore not an independent predictor of transplant failure, whereas the presence of antiidiotypic antibody activity did correlate with improved allograft survival.

KW - DONOR-SPECIFIC TRANSFUSION

KW - BLOOD-TRANSFUSIONS

KW - SUPPRESSOR CELLS

KW - GRAFT-SURVIVAL

KW - CYCLOSPORINE-A

KW - RECIPIENTS

KW - KIDNEY

KW - HLA

KW - ALLOANTIBODIES

KW - PREGNANCY

M3 - Article

VL - 40

SP - 80

EP - 85

JO - Kidney International

JF - Kidney International

SN - 0085-2538

IS - 1

ER -