Abstract
Both mutant p53 and chemoresistance are poor prognostic factors in cancer. Many studies have examined the influence of these factors on fluoro-2-deoxy-D-glucose (FDG) incorporation. Whilst mutant p53 is associated with increased FDG incorporation, chemoresistance, especially when associated with P-glycoprotein, is associated with decreased FDG incorporation.
| Original language | English |
|---|---|
| Pages (from-to) | 51-55 |
| Number of pages | 5 |
| Journal | Nuclear Medicine and Biology |
| Volume | 37 |
| Issue number | 1 |
| Early online date | 27 Aug 2009 |
| DOIs | |
| Publication status | Published - Jan 2010 |
Keywords
- radionuclide study
- treatment
- cancer
- 2-deoxy-2-fluoroglucose
- chemotherapy
- antineoplastic agent
- mutation
- p53 protein
- prognosis
- predictive factor
- human
- incorporation
- treatment resistance
- positron emission tomography
- emission tomography
- malignant tumor
Access to Document
- Influence of chemoresistance and p53 status on fluoro-2-deoxy-D-glucose incorporation in cancer
Smith, TAD 2010, 'Influence of chemoresistance and p53 status on fluoro-2-deoxy-D-glucose incorporation in cancer' Nuclear Medicine and Biology, vol 37, no. 1, pp. 51-55. doi: 10.1016/j.nucmedbio.2009.08.007