Influence of chemoresistance and p53 status on fluoro-2-deoxy-D-glucose incorporation in cancer

Tim A D Smith

Research output: Contribution to journalArticle

7 Citations (Scopus)
5 Downloads (Pure)

Abstract

Both mutant p53 and chemoresistance are poor prognostic factors in cancer. Many studies have examined the influence of these factors on fluoro-2-deoxy-D-glucose (FDG) incorporation. Whilst mutant p53 is associated with increased FDG incorporation, chemoresistance, especially when associated with P-glycoprotein, is associated with decreased FDG incorporation.
Original languageEnglish
Pages (from-to)51-55
Number of pages5
JournalNuclear Medicine and Biology
Volume37
Issue number1
Early online date27 Aug 2009
DOIs
Publication statusPublished - Jan 2010

Keywords

  • radionuclide study
  • treatment
  • cancer
  • 2-deoxy-2-fluoroglucose
  • chemotherapy
  • antineoplastic agent
  • mutation
  • p53 protein
  • prognosis
  • predictive factor
  • human
  • incorporation
  • treatment resistance
  • positron emission tomography
  • emission tomography
  • malignant tumor

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