Influence of exercise intensity on ERK/MAP kinase signalling in human skeletal muscle

U Widegren, C Wretman, Arimantas Lionikas, G Hedin, J Henriksson

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The mitogen-activated protein (MAP) kinase pathways have been highlighted as a possible link between exercise and adaptive changes in skeletal muscle. In this study, the effect of exercise intensity on the activation of the ERK/MAP kinase pathway was investigated in human skeletal muscle. One-leg exercise at low (40% maximal oxygen consumption, VO2max for 30 min) and high (75% VO2max for 30 min) intensity resulted in 11.5+8. I-fold and 39.7+/-6.3-fold (mean +/-SEM) increases in ERK1/2 phosphorylation (P
Original languageEnglish
Pages (from-to)317-22
Number of pages6
JournalPflugers Archiv : European Journal of Physiology
Issue number2-3
Publication statusPublished - 1 Dec 2000



  • Adult
  • Cyclic AMP Response Element-Binding Protein
  • Exercise
  • Female
  • Freeze Drying
  • Humans
  • Male
  • Mitogen-Activated Protein Kinase 1
  • Mitogen-Activated Protein Kinase 3
  • Mitogen-Activated Protein Kinases
  • Muscle, Skeletal
  • Oxygen Consumption
  • Phosphorylation
  • Signal Transduction

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