Influence of exercise intensity on ERK/MAP kinase signalling in human skeletal muscle

U Widegren; C Wretman; Arimantas Lionikas; G Hedin; J Henriksson

doi:10.1007/s004240000417

Influence of exercise intensity on ERK/MAP kinase signalling in human skeletal muscle

U Widegren, C Wretman, Arimantas Lionikas, G Hedin, J Henriksson

Medical Sciences

Research output: Contribution to journal › Article › peer-review

99 Citations (Scopus)

Abstract

The mitogen-activated protein (MAP) kinase pathways have been highlighted as a possible link between exercise and adaptive changes in skeletal muscle. In this study, the effect of exercise intensity on the activation of the ERK/MAP kinase pathway was investigated in human skeletal muscle. One-leg exercise at low (40% maximal oxygen consumption, VO2max for 30 min) and high (75% VO2max for 30 min) intensity resulted in 11.5+8. I-fold and 39.7+/-6.3-fold (mean +/-SEM) increases in ERK1/2 phosphorylation (P

Original language	English
Pages (from-to)	317-22
Number of pages	6
Journal	Pflugers Archiv : European Journal of Physiology
Volume	441
Issue number	2-3
DOIs	https://doi.org/10.1007/s004240000417
Publication status	Published - 1 Dec 2000

Keywords

Adult
Cyclic AMP Response Element-Binding Protein
Exercise
Female
Freeze Drying
Humans
Male
Mitogen-Activated Protein Kinase 1
Mitogen-Activated Protein Kinase 3
Mitogen-Activated Protein Kinases
Muscle, Skeletal
Oxygen Consumption
Phosphorylation
Signal Transduction

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10.1007/s004240000417

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title = "Influence of exercise intensity on ERK/MAP kinase signalling in human skeletal muscle",

abstract = "The mitogen-activated protein (MAP) kinase pathways have been highlighted as a possible link between exercise and adaptive changes in skeletal muscle. In this study, the effect of exercise intensity on the activation of the ERK/MAP kinase pathway was investigated in human skeletal muscle. One-leg exercise at low (40% maximal oxygen consumption, VO2max for 30 min) and high (75% VO2max for 30 min) intensity resulted in 11.5+8. I-fold and 39.7+/-6.3-fold (mean +/-SEM) increases in ERK1/2 phosphorylation (P",

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T1 - Influence of exercise intensity on ERK/MAP kinase signalling in human skeletal muscle

AU - Widegren, U

AU - Wretman, C

AU - Lionikas, Arimantas

AU - Hedin, G

AU - Henriksson, J

PY - 2000/12/1

Y1 - 2000/12/1

N2 - The mitogen-activated protein (MAP) kinase pathways have been highlighted as a possible link between exercise and adaptive changes in skeletal muscle. In this study, the effect of exercise intensity on the activation of the ERK/MAP kinase pathway was investigated in human skeletal muscle. One-leg exercise at low (40% maximal oxygen consumption, VO2max for 30 min) and high (75% VO2max for 30 min) intensity resulted in 11.5+8. I-fold and 39.7+/-6.3-fold (mean +/-SEM) increases in ERK1/2 phosphorylation (P

AB - The mitogen-activated protein (MAP) kinase pathways have been highlighted as a possible link between exercise and adaptive changes in skeletal muscle. In this study, the effect of exercise intensity on the activation of the ERK/MAP kinase pathway was investigated in human skeletal muscle. One-leg exercise at low (40% maximal oxygen consumption, VO2max for 30 min) and high (75% VO2max for 30 min) intensity resulted in 11.5+8. I-fold and 39.7+/-6.3-fold (mean +/-SEM) increases in ERK1/2 phosphorylation (P

KW - Adult

KW - Cyclic AMP Response Element-Binding Protein

KW - Exercise

KW - Female

KW - Freeze Drying

KW - Humans

KW - Male

KW - Mitogen-Activated Protein Kinase 1

KW - Mitogen-Activated Protein Kinase 3

KW - Mitogen-Activated Protein Kinases

KW - Muscle, Skeletal

KW - Oxygen Consumption

KW - Phosphorylation

KW - Signal Transduction

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DO - 10.1007/s004240000417

M3 - Article

C2 - 11211119

SN - 0031-6768

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EP - 322

JO - Pflugers Archiv : European Journal of Physiology

JF - Pflugers Archiv : European Journal of Physiology

IS - 2-3

ER -

Influence of exercise intensity on ERK/MAP kinase signalling in human skeletal muscle

Abstract

Keywords

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