Influence of galangin on HL-60 cell proliferation and survival

Charles Bestwick, Lesley Milne

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

The effect of galangin, a flavonol component of India root spice and the 'herbal' medicine propolis, on HL-60 human leukaemia cell survival is characterised. Galangin (1-100 mu M) exerted an antiproliferative effect that, with dose and exposure longevity, was progressively associated with an elevated hypodiploid DNA content and expression of the active form of caspase-3, principally prior to membrane damage. At >= 50 mu M, plasmamembrane phosphatidylserine exposure was observed. There was no evidence for intracellular oxidative stress as an orchestrator of cytotoxicity and significant phagocyte-like differentiation was not detected. We discuss whether such cytotoxicity will be therapeutically exploitable or contribute to cancer prevention within a pharmacological or dietary context. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)80-89
Number of pages10
JournalCancer Letters
Volume243
Issue number1
Early online date18 Jan 2006
DOIs
Publication statusPublished - 8 Nov 2006

Keywords

  • apoptosis
  • cytotoxicity
  • flavonoids
  • galangin
  • HL-60
  • potentially anticarcinogenic flavonoids
  • cancer prevention
  • leukemia-cells
  • HL60 cells
  • activation
  • quercetin
  • induction
  • Netherlands
  • polyphenols

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