Abstract
The effect of galangin, a flavonol component of India root spice and the 'herbal' medicine propolis, on HL-60 human leukaemia cell survival is characterised. Galangin (1-100 mu M) exerted an antiproliferative effect that, with dose and exposure longevity, was progressively associated with an elevated hypodiploid DNA content and expression of the active form of caspase-3, principally prior to membrane damage. At >= 50 mu M, plasmamembrane phosphatidylserine exposure was observed. There was no evidence for intracellular oxidative stress as an orchestrator of cytotoxicity and significant phagocyte-like differentiation was not detected. We discuss whether such cytotoxicity will be therapeutically exploitable or contribute to cancer prevention within a pharmacological or dietary context. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
Original language | English |
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Pages (from-to) | 80-89 |
Number of pages | 10 |
Journal | Cancer Letters |
Volume | 243 |
Issue number | 1 |
Early online date | 18 Jan 2006 |
DOIs | |
Publication status | Published - 8 Nov 2006 |
Keywords
- apoptosis
- cytotoxicity
- flavonoids
- galangin
- HL-60
- potentially anticarcinogenic flavonoids
- cancer prevention
- leukemia-cells
- HL60 cells
- activation
- quercetin
- induction
- Netherlands
- polyphenols