Influence of host gene polymorphisms on development of gastroduodenal diseases

Mairi H. McLean, Ruairidh Nicoll, Cheryl Saw, Georgina L. Hold, Emad M. El-Omar*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Helicobacter pylori infection remains the commonest chronic bacterial infection in the world and is associated with a variety of clinical outcomes that range from simple asymptomatic gastritis to more serious conditions such as peptic ulcer disease and gastric cancer. The key determinants of these outcomes are the severity and distribution of H. pylori-induced gastritis. Host genetic factors play an important role in influencing disease risk, but identifying candidate genes is a major challenge that has to stem from a profound understanding of the pathophysiology of the disease. In the case of H. pylori-associated disease, the initial search focused on candidate genes that attenuate gastric physiology and lead to a destructive chronic inflammatory response against the infection. In particular, certain cytokine and innate immune response gene polymorphisms appear to influence risk of gastric cancer and its precursor conditions. More recent genome-wide association studies have identified novel genetic markers that show impressive associations with gastric cancer risk but whose function remains unclear. Very recently, there has been progress in identifying genetic risk markers for acquisition of H. pylori infection, but there remains a lack of suitable markers for risk of peptic ulcer disease. Future research agenda should focus on identifying the full genetic risk profile for H. pylori-induced gastroduodenal disease. This will help target the population most at risk by directing eradication therapy and closer follow-up to the affected individuals.

Original languageEnglish
Title of host publicationHelicobacter pylori Research
Subtitle of host publicationFrom Bench to Bedside
EditorsSteffen Backert, Yoshio Yamaoka
PublisherSpringer Japan
Pages339-362
Number of pages24
Edition1
ISBN (Electronic)978-4-431-55936-8
ISBN (Print)978-4-431-55934-4
DOIs
Publication statusPublished - 1 Jan 2016

Fingerprint

Helicobacter pylori
Genes
Stomach Neoplasms
Helicobacter Infections
Gastritis
Peptic Ulcer
Genetic Markers
Health Services Needs and Demand
Genome-Wide Association Study
Bacterial Infections
Innate Immunity
Stomach
Cytokines
Infection
Therapeutics

Keywords

  • Chronic inflammation
  • Gastric cancer
  • Genetic polymorphisms
  • Helicobacter pylori
  • Host genetics
  • MALT lymphoma
  • Peptic ulcer disease

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)

Cite this

McLean, M. H., Nicoll, R., Saw, C., Hold, G. L., & El-Omar, E. M. (2016). Influence of host gene polymorphisms on development of gastroduodenal diseases. In S. Backert, & Y. Yamaoka (Eds.), Helicobacter pylori Research: From Bench to Bedside (1 ed., pp. 339-362). Springer Japan. https://doi.org/10.1007/978-4-431-55936-8_14

Influence of host gene polymorphisms on development of gastroduodenal diseases. / McLean, Mairi H.; Nicoll, Ruairidh; Saw, Cheryl; Hold, Georgina L.; El-Omar, Emad M.

Helicobacter pylori Research: From Bench to Bedside. ed. / Steffen Backert; Yoshio Yamaoka. 1. ed. Springer Japan, 2016. p. 339-362.

Research output: Chapter in Book/Report/Conference proceedingChapter

McLean, MH, Nicoll, R, Saw, C, Hold, GL & El-Omar, EM 2016, Influence of host gene polymorphisms on development of gastroduodenal diseases. in S Backert & Y Yamaoka (eds), Helicobacter pylori Research: From Bench to Bedside. 1 edn, Springer Japan, pp. 339-362. https://doi.org/10.1007/978-4-431-55936-8_14
McLean MH, Nicoll R, Saw C, Hold GL, El-Omar EM. Influence of host gene polymorphisms on development of gastroduodenal diseases. In Backert S, Yamaoka Y, editors, Helicobacter pylori Research: From Bench to Bedside. 1 ed. Springer Japan. 2016. p. 339-362 https://doi.org/10.1007/978-4-431-55936-8_14
McLean, Mairi H. ; Nicoll, Ruairidh ; Saw, Cheryl ; Hold, Georgina L. ; El-Omar, Emad M. / Influence of host gene polymorphisms on development of gastroduodenal diseases. Helicobacter pylori Research: From Bench to Bedside. editor / Steffen Backert ; Yoshio Yamaoka. 1. ed. Springer Japan, 2016. pp. 339-362
@inbook{9bdbef080861422d964b191d5389ed7c,
title = "Influence of host gene polymorphisms on development of gastroduodenal diseases",
abstract = "Helicobacter pylori infection remains the commonest chronic bacterial infection in the world and is associated with a variety of clinical outcomes that range from simple asymptomatic gastritis to more serious conditions such as peptic ulcer disease and gastric cancer. The key determinants of these outcomes are the severity and distribution of H. pylori-induced gastritis. Host genetic factors play an important role in influencing disease risk, but identifying candidate genes is a major challenge that has to stem from a profound understanding of the pathophysiology of the disease. In the case of H. pylori-associated disease, the initial search focused on candidate genes that attenuate gastric physiology and lead to a destructive chronic inflammatory response against the infection. In particular, certain cytokine and innate immune response gene polymorphisms appear to influence risk of gastric cancer and its precursor conditions. More recent genome-wide association studies have identified novel genetic markers that show impressive associations with gastric cancer risk but whose function remains unclear. Very recently, there has been progress in identifying genetic risk markers for acquisition of H. pylori infection, but there remains a lack of suitable markers for risk of peptic ulcer disease. Future research agenda should focus on identifying the full genetic risk profile for H. pylori-induced gastroduodenal disease. This will help target the population most at risk by directing eradication therapy and closer follow-up to the affected individuals.",
keywords = "Chronic inflammation, Gastric cancer, Genetic polymorphisms, Helicobacter pylori, Host genetics, MALT lymphoma, Peptic ulcer disease",
author = "McLean, {Mairi H.} and Ruairidh Nicoll and Cheryl Saw and Hold, {Georgina L.} and El-Omar, {Emad M.}",
year = "2016",
month = "1",
day = "1",
doi = "10.1007/978-4-431-55936-8_14",
language = "English",
isbn = "978-4-431-55934-4",
pages = "339--362",
editor = "Backert, {Steffen } and Yamaoka, {Yoshio }",
booktitle = "Helicobacter pylori Research",
publisher = "Springer Japan",
address = "Japan",
edition = "1",

}

TY - CHAP

T1 - Influence of host gene polymorphisms on development of gastroduodenal diseases

AU - McLean, Mairi H.

AU - Nicoll, Ruairidh

AU - Saw, Cheryl

AU - Hold, Georgina L.

AU - El-Omar, Emad M.

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Helicobacter pylori infection remains the commonest chronic bacterial infection in the world and is associated with a variety of clinical outcomes that range from simple asymptomatic gastritis to more serious conditions such as peptic ulcer disease and gastric cancer. The key determinants of these outcomes are the severity and distribution of H. pylori-induced gastritis. Host genetic factors play an important role in influencing disease risk, but identifying candidate genes is a major challenge that has to stem from a profound understanding of the pathophysiology of the disease. In the case of H. pylori-associated disease, the initial search focused on candidate genes that attenuate gastric physiology and lead to a destructive chronic inflammatory response against the infection. In particular, certain cytokine and innate immune response gene polymorphisms appear to influence risk of gastric cancer and its precursor conditions. More recent genome-wide association studies have identified novel genetic markers that show impressive associations with gastric cancer risk but whose function remains unclear. Very recently, there has been progress in identifying genetic risk markers for acquisition of H. pylori infection, but there remains a lack of suitable markers for risk of peptic ulcer disease. Future research agenda should focus on identifying the full genetic risk profile for H. pylori-induced gastroduodenal disease. This will help target the population most at risk by directing eradication therapy and closer follow-up to the affected individuals.

AB - Helicobacter pylori infection remains the commonest chronic bacterial infection in the world and is associated with a variety of clinical outcomes that range from simple asymptomatic gastritis to more serious conditions such as peptic ulcer disease and gastric cancer. The key determinants of these outcomes are the severity and distribution of H. pylori-induced gastritis. Host genetic factors play an important role in influencing disease risk, but identifying candidate genes is a major challenge that has to stem from a profound understanding of the pathophysiology of the disease. In the case of H. pylori-associated disease, the initial search focused on candidate genes that attenuate gastric physiology and lead to a destructive chronic inflammatory response against the infection. In particular, certain cytokine and innate immune response gene polymorphisms appear to influence risk of gastric cancer and its precursor conditions. More recent genome-wide association studies have identified novel genetic markers that show impressive associations with gastric cancer risk but whose function remains unclear. Very recently, there has been progress in identifying genetic risk markers for acquisition of H. pylori infection, but there remains a lack of suitable markers for risk of peptic ulcer disease. Future research agenda should focus on identifying the full genetic risk profile for H. pylori-induced gastroduodenal disease. This will help target the population most at risk by directing eradication therapy and closer follow-up to the affected individuals.

KW - Chronic inflammation

KW - Gastric cancer

KW - Genetic polymorphisms

KW - Helicobacter pylori

KW - Host genetics

KW - MALT lymphoma

KW - Peptic ulcer disease

UR - http://www.scopus.com/inward/record.url?scp=84988672707&partnerID=8YFLogxK

U2 - 10.1007/978-4-431-55936-8_14

DO - 10.1007/978-4-431-55936-8_14

M3 - Chapter

SN - 978-4-431-55934-4

SP - 339

EP - 362

BT - Helicobacter pylori Research

A2 - Backert, Steffen

A2 - Yamaoka, Yoshio

PB - Springer Japan

ER -