Influence of LRP5 polymorphisms on normal variation in BMD

M A  Koay; P Y  Woon; Y  Zhang; L J  Miles; E L  Duncan; S H  Ralston; J E  Compston; C  Cooper; R  Keen; B L  Langdahl; A  MacLelland; J  O'Riordan; H A  Pols; D M  Reid; A G  Uitterlinden; J A H  Wass; M A  Brown

doi:10.1359/JBMR.040704

Influence of LRP5 polymorphisms on normal variation in BMD

M A Koay, P Y Woon, Y Zhang, L J Miles, E L Duncan, S H Ralston, J E Compston, C Cooper, R Keen, B L Langdahl, A MacLelland, J O'Riordan, H A Pols, D M Reid, A G Uitterlinden, J A H Wass, M A Brown

Applied Medicine

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Abstract

Genetic studies based on cohorts with rare and extreme bone phenotypes have shown that the LRP5 gene is an important genetic modulator of BMD. Using family-based and case-control approaches, this study examines the role of the LRP5 gene in determining normal population variation of BMD and describes significant association and suggestive linkage between LRP5 gene polymorphisms and BMD in >900 individuals with a broad range of BMD.

Original language	English
Pages (from-to)	1619-1627
Number of pages	9
Journal	Journal of Bone and Mineral Research
Volume	19
DOIs	https://doi.org/10.1359/JBMR.040704
Publication status	Published - 2004

Keywords

osteoporosis
single nucleotide polymorphism
linkage
association
LRP5 gene
BONE-MINERAL DENSITY
RECEPTOR-RELATED PROTEIN-5
TOF MASS-SPECTROMETRY
CHROMOSOME 11Q12-13
LINKAGE ANALYSIS
MAJOR GENE
OSTEOPOROSIS
FAMILIES
MUTATION
DETERMINANTS

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Koay, M. A., Woon, P. Y., Zhang, Y., Miles, L. J., Duncan, E. L., Ralston, S. H., Compston, J. E., Cooper, C., Keen, R., Langdahl, B. L., MacLelland, A., O'Riordan, J., Pols, H. A., Reid, D. M., Uitterlinden, A. G., Wass, J. A. H., & Brown, M. A. (2004). Influence of LRP5 polymorphisms on normal variation in BMD. Journal of Bone and Mineral Research, 19, 1619-1627. https://doi.org/10.1359/JBMR.040704

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abstract = "Genetic studies based on cohorts with rare and extreme bone phenotypes have shown that the LRP5 gene is an important genetic modulator of BMD. Using family-based and case-control approaches, this study examines the role of the LRP5 gene in determining normal population variation of BMD and describes significant association and suggestive linkage between LRP5 gene polymorphisms and BMD in >900 individuals with a broad range of BMD.",

keywords = "osteoporosis, single nucleotide polymorphism, linkage, association, LRP5 gene, BONE-MINERAL DENSITY, RECEPTOR-RELATED PROTEIN-5, TOF MASS-SPECTROMETRY, CHROMOSOME 11Q12-13, LINKAGE ANALYSIS, MAJOR GENE, OSTEOPOROSIS, FAMILIES, MUTATION, DETERMINANTS",

author = "Koay, {M A} and Woon, {P Y} and Y Zhang and Miles, {L J} and Duncan, {E L} and Ralston, {S H} and Compston, {J E} and C Cooper and R Keen and Langdahl, {B L} and A MacLelland and J O'Riordan and Pols, {H A} and Reid, {D M} and Uitterlinden, {A G} and Wass, {J A H} and Brown, {M A}",

year = "2004",

doi = "10.1359/JBMR.040704",

language = "English",

volume = "19",

pages = "1619--1627",

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T1 - Influence of LRP5 polymorphisms on normal variation in BMD

AU - Koay, M A

AU - Woon, P Y

AU - Zhang, Y

AU - Miles, L J

AU - Duncan, E L

AU - Ralston, S H

AU - Compston, J E

AU - Cooper, C

AU - Keen, R

AU - Langdahl, B L

AU - MacLelland, A

AU - O'Riordan, J

AU - Pols, H A

AU - Reid, D M

AU - Uitterlinden, A G

AU - Wass, J A H

AU - Brown, M A

PY - 2004

Y1 - 2004

N2 - Genetic studies based on cohorts with rare and extreme bone phenotypes have shown that the LRP5 gene is an important genetic modulator of BMD. Using family-based and case-control approaches, this study examines the role of the LRP5 gene in determining normal population variation of BMD and describes significant association and suggestive linkage between LRP5 gene polymorphisms and BMD in >900 individuals with a broad range of BMD.

AB - Genetic studies based on cohorts with rare and extreme bone phenotypes have shown that the LRP5 gene is an important genetic modulator of BMD. Using family-based and case-control approaches, this study examines the role of the LRP5 gene in determining normal population variation of BMD and describes significant association and suggestive linkage between LRP5 gene polymorphisms and BMD in >900 individuals with a broad range of BMD.

KW - osteoporosis

KW - single nucleotide polymorphism

KW - linkage

KW - association

KW - LRP5 gene

KW - BONE-MINERAL DENSITY

KW - RECEPTOR-RELATED PROTEIN-5

KW - TOF MASS-SPECTROMETRY

KW - CHROMOSOME 11Q12-13

KW - LINKAGE ANALYSIS

KW - MAJOR GENE

KW - OSTEOPOROSIS

KW - FAMILIES

KW - MUTATION

KW - DETERMINANTS

U2 - 10.1359/JBMR.040704

DO - 10.1359/JBMR.040704

M3 - Article

SN - 1523-4681

VL - 19

SP - 1619

EP - 1627

JO - Journal of Bone and Mineral Research

JF - Journal of Bone and Mineral Research

ER -

Influence of LRP5 polymorphisms on normal variation in BMD

Abstract

Keywords

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