Influence of LRP5 polymorphisms on normal variation in BMD

M A Koay, P Y Woon, Y Zhang, L J Miles, E L Duncan, S H Ralston, J E Compston, C Cooper, R Keen, B L Langdahl, A MacLelland, J O'Riordan, H A Pols, D M Reid, A G Uitterlinden, J A H Wass, M A Brown

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Abstract

Genetic studies based on cohorts with rare and extreme bone phenotypes have shown that the LRP5 gene is an important genetic modulator of BMD. Using family-based and case-control approaches, this study examines the role of the LRP5 gene in determining normal population variation of BMD and describes significant association and suggestive linkage between LRP5 gene polymorphisms and BMD in >900 individuals with a broad range of BMD.

Original languageEnglish
Pages (from-to)1619-1627
Number of pages9
JournalJournal of Bone and Mineral Research
Volume19
DOIs
Publication statusPublished - 2004

Keywords

  • osteoporosis
  • single nucleotide polymorphism
  • linkage
  • association
  • LRP5 gene
  • BONE-MINERAL DENSITY
  • RECEPTOR-RELATED PROTEIN-5
  • TOF MASS-SPECTROMETRY
  • CHROMOSOME 11Q12-13
  • LINKAGE ANALYSIS
  • MAJOR GENE
  • OSTEOPOROSIS
  • FAMILIES
  • MUTATION
  • DETERMINANTS

Cite this

Koay, M. A., Woon, P. Y., Zhang, Y., Miles, L. J., Duncan, E. L., Ralston, S. H., Compston, J. E., Cooper, C., Keen, R., Langdahl, B. L., MacLelland, A., O'Riordan, J., Pols, H. A., Reid, D. M., Uitterlinden, A. G., Wass, J. A. H., & Brown, M. A. (2004). Influence of LRP5 polymorphisms on normal variation in BMD. Journal of Bone and Mineral Research, 19, 1619-1627. https://doi.org/10.1359/JBMR.040704