Influence of phase purity on the in vivo response to hydroxyapatite

K A Hing, I R Gibson, P A Revell, S M Best, W Bonfield

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Two batches of calcium phosphate implants, termed HA1 and HA2 were prepared with calcium to phosphorus ratios of 1.67 and 1.70 respectively. XRD demonstrated that the HA1 implants were composed of phase pure hydroxyapatite, while the phase composition of the HA2 implants contained approximately 5% calcium oxide with the balance being hydroxyapatite. Sintered cylindrical implants, 3 mm in diameter, were prepared from each of the powders, containing slots I mm wide x 2 mm deep in one circular face. The implants were implanted laterally in the distal femur of 6 month old New Zealand white rabbits for a period of 3 weeks.

Subsequent histological evaluation demonstrated that the presence of the CaO impurity phase significantly reduced the osteoconductivity, as demonstrated by minimal penetration of new bone within HA2 implant slots and a significant reduction in direct bone apposition on any of the HA2 implant surfaces as compared with HA1 implants. This study has confirmed the need for precise control of the phase purity of hydroxyapatite based bioceramics for optimal biological performance.

Original languageEnglish
Title of host publicationBIOCERAMICS
EditorsS Giannini, A Moroni
Place of PublicationZURICH-UETIKON
PublisherTrans Tech Publications Ltd
Pages373-376
Number of pages4
ISBN (Print)0-87849-866-4
Publication statusPublished - 2000
Event13th International Symposium on Ceramic in Medicine /Symposium on Ceramic Materials in Orthopaedic Surgery: Clinical Results in the Year 2000 - BOLOGNA
Duration: 22 Nov 200026 Nov 2000

Conference

Conference13th International Symposium on Ceramic in Medicine /Symposium on Ceramic Materials in Orthopaedic Surgery: Clinical Results in the Year 2000
CityBOLOGNA
Period22/11/0026/11/00

Keywords

  • biological response
  • bone
  • hydroxyapatite HA
  • phase purity
  • POROUS HYDROXYAPATITE
  • BONE INGROWTH

Cite this

Hing, K. A., Gibson, I. R., Revell, P. A., Best, S. M., & Bonfield, W. (2000). Influence of phase purity on the in vivo response to hydroxyapatite. In S. Giannini, & A. Moroni (Eds.), BIOCERAMICS (pp. 373-376). ZURICH-UETIKON: Trans Tech Publications Ltd.

Influence of phase purity on the in vivo response to hydroxyapatite. / Hing, K A ; Gibson, I R ; Revell, P A ; Best, S M ; Bonfield, W .

BIOCERAMICS. ed. / S Giannini; A Moroni. ZURICH-UETIKON : Trans Tech Publications Ltd, 2000. p. 373-376.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Hing, KA, Gibson, IR, Revell, PA, Best, SM & Bonfield, W 2000, Influence of phase purity on the in vivo response to hydroxyapatite. in S Giannini & A Moroni (eds), BIOCERAMICS. Trans Tech Publications Ltd, ZURICH-UETIKON, pp. 373-376, 13th International Symposium on Ceramic in Medicine /Symposium on Ceramic Materials in Orthopaedic Surgery: Clinical Results in the Year 2000, BOLOGNA, 22/11/00.
Hing KA, Gibson IR, Revell PA, Best SM, Bonfield W. Influence of phase purity on the in vivo response to hydroxyapatite. In Giannini S, Moroni A, editors, BIOCERAMICS. ZURICH-UETIKON: Trans Tech Publications Ltd. 2000. p. 373-376
Hing, K A ; Gibson, I R ; Revell, P A ; Best, S M ; Bonfield, W . / Influence of phase purity on the in vivo response to hydroxyapatite. BIOCERAMICS. editor / S Giannini ; A Moroni. ZURICH-UETIKON : Trans Tech Publications Ltd, 2000. pp. 373-376
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N2 - Two batches of calcium phosphate implants, termed HA1 and HA2 were prepared with calcium to phosphorus ratios of 1.67 and 1.70 respectively. XRD demonstrated that the HA1 implants were composed of phase pure hydroxyapatite, while the phase composition of the HA2 implants contained approximately 5% calcium oxide with the balance being hydroxyapatite. Sintered cylindrical implants, 3 mm in diameter, were prepared from each of the powders, containing slots I mm wide x 2 mm deep in one circular face. The implants were implanted laterally in the distal femur of 6 month old New Zealand white rabbits for a period of 3 weeks.Subsequent histological evaluation demonstrated that the presence of the CaO impurity phase significantly reduced the osteoconductivity, as demonstrated by minimal penetration of new bone within HA2 implant slots and a significant reduction in direct bone apposition on any of the HA2 implant surfaces as compared with HA1 implants. This study has confirmed the need for precise control of the phase purity of hydroxyapatite based bioceramics for optimal biological performance.

AB - Two batches of calcium phosphate implants, termed HA1 and HA2 were prepared with calcium to phosphorus ratios of 1.67 and 1.70 respectively. XRD demonstrated that the HA1 implants were composed of phase pure hydroxyapatite, while the phase composition of the HA2 implants contained approximately 5% calcium oxide with the balance being hydroxyapatite. Sintered cylindrical implants, 3 mm in diameter, were prepared from each of the powders, containing slots I mm wide x 2 mm deep in one circular face. The implants were implanted laterally in the distal femur of 6 month old New Zealand white rabbits for a period of 3 weeks.Subsequent histological evaluation demonstrated that the presence of the CaO impurity phase significantly reduced the osteoconductivity, as demonstrated by minimal penetration of new bone within HA2 implant slots and a significant reduction in direct bone apposition on any of the HA2 implant surfaces as compared with HA1 implants. This study has confirmed the need for precise control of the phase purity of hydroxyapatite based bioceramics for optimal biological performance.

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KW - bone

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