Information on Genetic Variants Does Not Increase Identification of Individuals at Risk of Esophageal Adenocarcinoma Compared to Clinical Risk Factors

Andrew T. Kunzmann; Marisa Cañadas Garre; Aaron P. Thrift; Úna C. McMenamin; Brian T. Johnston; Chris R. Cardwell; Lesley A. Anderson; Andrew D. Spence; Jesper Lagergren; Shao Hua Xie; Laura J. Smyth; Amy Jayne McKnight; Helen G. Coleman

doi:10.1053/j.gastro.2018.09.038

Information on Genetic Variants Does Not Increase Identification of Individuals at Risk of Esophageal Adenocarcinoma Compared to Clinical Risk Factors

Andrew T. Kunzmann^* (Corresponding Author), Marisa Cañadas Garre, Aaron P. Thrift, Úna C. McMenamin, Brian T. Johnston, Chris R. Cardwell, Lesley A. Anderson, Andrew D. Spence, Jesper Lagergren, Shao Hua Xie, Laura J. Smyth, Amy Jayne McKnight, Helen G. Coleman

^*Corresponding author for this work

Applied Health Sciences

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

We previously developed a tool that identified individuals who later developed esophageal adenocarcinoma (based on age, sex, body mass index, smoking status, and prior esophageal conditions) with an area under the curve of 0.80. In this study, we collected data from 329,463 individuals in the UK Biobank cohort who were tested for genetic susceptibility to esophageal adenocarcinoma (a polygenic risk score based on 18 recognized genetic variants). We found that after inclusion of this genetic information, the area under the curve for identification of individuals who developed esophageal adenocarcinoma remained at 0.80. Testing for genetic variants associated with esophageal adenocarcinoma therefore seems unlikely to improve identification of individuals at risk of esophageal adenocarcinoma.

Original language	English
Pages (from-to)	43-45
Number of pages	3
Journal	Gastroenterology
Volume	156
Issue number	1
Early online date	18 Sept 2018
DOIs	https://doi.org/10.1053/j.gastro.2018.09.038
Publication status	Published - Jan 2019

Bibliographical note

Acknowledgments
Author contributions: Andrew T. Kunzmann: study concept and design; acquisition of data; analysis and interpretation of data; drafting of the manuscript; critical revision of the manuscript for important intellectual content; statistical analysis; obtained funding. Marissa Canadas Garre: acquisition of data; analysis and interpretation of data; statistical analysis; critical revision of the manuscript for important intellectual content. Úna C. McMenamin: acquisition of data; critical revision of the manuscript for important intellectual content. Chris R. Cardwell: acquisition of data; analysis and interpretation of data; critical revision of the manuscript for important intellectual content. Aaron P. Thrift, Brian T. Johnston, Lesley A. Anderson, Andrew D. Spence, Jesper Lagergren, Shao-Hua Xie, Laura J. Smyth, and Amy Jayne McKnight: critical revision of the manuscript for important intellectual content. Helen G. Coleman: study concept and design; acquisition of data; critical revision of the manuscript for important intellectual content; study supervision.

This research has been conducted using the UK Biobank Resource under Application Number 34374.

Keywords

Cancer
Early Detection
Esophagus
Mutation
Stratification

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1053/j.gastro.2018.09.038Licence: Unspecified

Cite this

Kunzmann, A. T., Cañadas Garre, M., Thrift, A. P., McMenamin, Ú. C., Johnston, B. T., Cardwell, C. R., Anderson, L. A., Spence, A. D., Lagergren, J., Xie, S. H., Smyth, L. J., McKnight, A. J., & Coleman, H. G. (2019). Information on Genetic Variants Does Not Increase Identification of Individuals at Risk of Esophageal Adenocarcinoma Compared to Clinical Risk Factors. Gastroenterology, 156(1), 43-45. https://doi.org/10.1053/j.gastro.2018.09.038

Information on Genetic Variants Does Not Increase Identification of Individuals at Risk of Esophageal Adenocarcinoma Compared to Clinical Risk Factors. / Kunzmann, Andrew T. (Corresponding Author); Cañadas Garre, Marisa; Thrift, Aaron P. et al.
In: Gastroenterology, Vol. 156, No. 1, 01.2019, p. 43-45.

Research output: Contribution to journal › Article › peer-review

Kunzmann, AT, Cañadas Garre, M, Thrift, AP, McMenamin, ÚC, Johnston, BT, Cardwell, CR, Anderson, LA, Spence, AD, Lagergren, J, Xie, SH, Smyth, LJ, McKnight, AJ & Coleman, HG 2019, 'Information on Genetic Variants Does Not Increase Identification of Individuals at Risk of Esophageal Adenocarcinoma Compared to Clinical Risk Factors', Gastroenterology, vol. 156, no. 1, pp. 43-45. https://doi.org/10.1053/j.gastro.2018.09.038

@article{068499f7f2694a7d9a87978fd54b92cb,

title = "Information on Genetic Variants Does Not Increase Identification of Individuals at Risk of Esophageal Adenocarcinoma Compared to Clinical Risk Factors",

abstract = "We previously developed a tool that identified individuals who later developed esophageal adenocarcinoma (based on age, sex, body mass index, smoking status, and prior esophageal conditions) with an area under the curve of 0.80. In this study, we collected data from 329,463 individuals in the UK Biobank cohort who were tested for genetic susceptibility to esophageal adenocarcinoma (a polygenic risk score based on 18 recognized genetic variants). We found that after inclusion of this genetic information, the area under the curve for identification of individuals who developed esophageal adenocarcinoma remained at 0.80. Testing for genetic variants associated with esophageal adenocarcinoma therefore seems unlikely to improve identification of individuals at risk of esophageal adenocarcinoma.",

keywords = "Cancer, Early Detection, Esophagus, Mutation, Stratification",

author = "Kunzmann, {Andrew T.} and {Ca{\~n}adas Garre}, Marisa and Thrift, {Aaron P.} and McMenamin, {{\'U}na C.} and Johnston, {Brian T.} and Cardwell, {Chris R.} and Anderson, {Lesley A.} and Spence, {Andrew D.} and Jesper Lagergren and Xie, {Shao Hua} and Smyth, {Laura J.} and McKnight, {Amy Jayne} and Coleman, {Helen G.}",

note = "Acknowledgments Author contributions: Andrew T. Kunzmann: study concept and design; acquisition of data; analysis and interpretation of data; drafting of the manuscript; critical revision of the manuscript for important intellectual content; statistical analysis; obtained funding. Marissa Canadas Garre: acquisition of data; analysis and interpretation of data; statistical analysis; critical revision of the manuscript for important intellectual content. {\'U}na C. McMenamin: acquisition of data; critical revision of the manuscript for important intellectual content. Chris R. Cardwell: acquisition of data; analysis and interpretation of data; critical revision of the manuscript for important intellectual content. Aaron P. Thrift, Brian T. Johnston, Lesley A. Anderson, Andrew D. Spence, Jesper Lagergren, Shao-Hua Xie, Laura J. Smyth, and Amy Jayne McKnight: critical revision of the manuscript for important intellectual content. Helen G. Coleman: study concept and design; acquisition of data; critical revision of the manuscript for important intellectual content; study supervision. This research has been conducted using the UK Biobank Resource under Application Number 34374.",

year = "2019",

month = jan,

doi = "10.1053/j.gastro.2018.09.038",

language = "English",

volume = "156",

pages = "43--45",

journal = "Gastroenterology",

issn = "0016-5085",

publisher = "W B SAUNDERS CO-ELSEVIER INC",

number = "1",

}

TY - JOUR

T1 - Information on Genetic Variants Does Not Increase Identification of Individuals at Risk of Esophageal Adenocarcinoma Compared to Clinical Risk Factors

AU - Kunzmann, Andrew T.

AU - Cañadas Garre, Marisa

AU - Thrift, Aaron P.

AU - McMenamin, Úna C.

AU - Johnston, Brian T.

AU - Cardwell, Chris R.

AU - Anderson, Lesley A.

AU - Spence, Andrew D.

AU - Lagergren, Jesper

AU - Xie, Shao Hua

AU - Smyth, Laura J.

AU - McKnight, Amy Jayne

AU - Coleman, Helen G.

N1 - Acknowledgments Author contributions: Andrew T. Kunzmann: study concept and design; acquisition of data; analysis and interpretation of data; drafting of the manuscript; critical revision of the manuscript for important intellectual content; statistical analysis; obtained funding. Marissa Canadas Garre: acquisition of data; analysis and interpretation of data; statistical analysis; critical revision of the manuscript for important intellectual content. Úna C. McMenamin: acquisition of data; critical revision of the manuscript for important intellectual content. Chris R. Cardwell: acquisition of data; analysis and interpretation of data; critical revision of the manuscript for important intellectual content. Aaron P. Thrift, Brian T. Johnston, Lesley A. Anderson, Andrew D. Spence, Jesper Lagergren, Shao-Hua Xie, Laura J. Smyth, and Amy Jayne McKnight: critical revision of the manuscript for important intellectual content. Helen G. Coleman: study concept and design; acquisition of data; critical revision of the manuscript for important intellectual content; study supervision. This research has been conducted using the UK Biobank Resource under Application Number 34374.

PY - 2019/1

Y1 - 2019/1

N2 - We previously developed a tool that identified individuals who later developed esophageal adenocarcinoma (based on age, sex, body mass index, smoking status, and prior esophageal conditions) with an area under the curve of 0.80. In this study, we collected data from 329,463 individuals in the UK Biobank cohort who were tested for genetic susceptibility to esophageal adenocarcinoma (a polygenic risk score based on 18 recognized genetic variants). We found that after inclusion of this genetic information, the area under the curve for identification of individuals who developed esophageal adenocarcinoma remained at 0.80. Testing for genetic variants associated with esophageal adenocarcinoma therefore seems unlikely to improve identification of individuals at risk of esophageal adenocarcinoma.

AB - We previously developed a tool that identified individuals who later developed esophageal adenocarcinoma (based on age, sex, body mass index, smoking status, and prior esophageal conditions) with an area under the curve of 0.80. In this study, we collected data from 329,463 individuals in the UK Biobank cohort who were tested for genetic susceptibility to esophageal adenocarcinoma (a polygenic risk score based on 18 recognized genetic variants). We found that after inclusion of this genetic information, the area under the curve for identification of individuals who developed esophageal adenocarcinoma remained at 0.80. Testing for genetic variants associated with esophageal adenocarcinoma therefore seems unlikely to improve identification of individuals at risk of esophageal adenocarcinoma.

KW - Cancer

KW - Early Detection

KW - Esophagus

KW - Mutation

KW - Stratification

UR - http://www.scopus.com/inward/record.url?scp=85058437589&partnerID=8YFLogxK

UR - https://pure.qub.ac.uk/en/publications/information-on-genetic-variants-does-not-increase-identification-

U2 - 10.1053/j.gastro.2018.09.038

DO - 10.1053/j.gastro.2018.09.038

M3 - Article

C2 - 30243622

AN - SCOPUS:85058437589

SN - 0016-5085

VL - 156

SP - 43

EP - 45

JO - Gastroenterology

JF - Gastroenterology

IS - 1

ER -

Information on Genetic Variants Does Not Increase Identification of Individuals at Risk of Esophageal Adenocarcinoma Compared to Clinical Risk Factors

Abstract

Bibliographical note

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this