Inhibition of autoimmune encephalomyelitis by a tetracycline

N. Popovic, A. Schubart, B. D. Goetz, S. C. Zhang, Christopher Linington, D. Duncan

    Research output: Contribution to journalArticle

    234 Citations (Scopus)

    Abstract

    We have explored the use of minocycline, a tetracycline with antiinflammatory properties, to treat chronic relapsing-remitting experimental allergic encephalomyelitis, an animal model of multiple sclerosis. Therapeutic treatment with minocycline dramatically suppresses ongoing disease activity and limits disease progression. Disease suppression is associated with immune deviation in the periphery and with suppression of the inflammatory cascade in the central nervous system. This association is demonstrated by inhibition of microglial activation and metalloproteinase-2 expression, which results in a concomitant decrease in inflammation and demyelination. As an established antiinflammatory drug with neuroprotective properties, minocycline may provide a novel therapeutic agent for relapsing-remitting multiple sclerosis.

    Original languageEnglish
    Pages (from-to)215-223
    Number of pages8
    JournalAnnals of Neurology
    Volume51
    DOIs
    Publication statusPublished - 2002

    Keywords

    • MYELIN OLIGODENDROCYTE GLYCOPROTEIN
    • EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS
    • MULTIPLE-SCLEROSIS LESIONS
    • MINOCYCLINE
    • INTERLEUKIN-10
    • DEMYELINATION
    • PATHOGENESIS
    • ARTHRITIS
    • MICROGLIA
    • DISORDERS

    Cite this

    Popovic, N., Schubart, A., Goetz, B. D., Zhang, S. C., Linington, C., & Duncan, D. (2002). Inhibition of autoimmune encephalomyelitis by a tetracycline. Annals of Neurology, 51, 215-223. https://doi.org/10.1002/ana.10092

    Inhibition of autoimmune encephalomyelitis by a tetracycline. / Popovic, N.; Schubart, A.; Goetz, B. D.; Zhang, S. C.; Linington, Christopher; Duncan, D.

    In: Annals of Neurology, Vol. 51, 2002, p. 215-223.

    Research output: Contribution to journalArticle

    Popovic, N, Schubart, A, Goetz, BD, Zhang, SC, Linington, C & Duncan, D 2002, 'Inhibition of autoimmune encephalomyelitis by a tetracycline', Annals of Neurology, vol. 51, pp. 215-223. https://doi.org/10.1002/ana.10092
    Popovic N, Schubart A, Goetz BD, Zhang SC, Linington C, Duncan D. Inhibition of autoimmune encephalomyelitis by a tetracycline. Annals of Neurology. 2002;51:215-223. https://doi.org/10.1002/ana.10092
    Popovic, N. ; Schubart, A. ; Goetz, B. D. ; Zhang, S. C. ; Linington, Christopher ; Duncan, D. / Inhibition of autoimmune encephalomyelitis by a tetracycline. In: Annals of Neurology. 2002 ; Vol. 51. pp. 215-223.
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