Inhibition of neutrophil function by the Kaposi's sarcoma-associated herpesvirus vOX2 protein

S. A.Rahim Rezaee, J. Alastair Gracie, Iain B. McInnes, David J. Blackbourn

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)

Abstract

Kaposi's sarcoma is multifactorial, involving Kaposi's sarcoma-associated herpesvirus (KSHV) infection and immune dysfunction. A KSHV protein (vOX2), fused with the Fc domain of human immunoglobulin G1 to create vOX2:Fc, suppressed neutrophil oxidative burst and inhibited the production of pro-inflammatory chemokines (IL-8 and monocyte chemoattractant protein 1) by monocyte/macrophage cells. vOX2:Fc suppressed the acute inflammatory response in mice in which neutrophil-mediated inflammation was induced by carrageenan. The data suggest that vOX2 can contribute to immune dysfunction and could have anti-inflammatory therapeutic potential.

Original languageEnglish
Pages (from-to)1907-1910
Number of pages4
JournalAIDS
Volume19
Issue number16
DOIs
Publication statusPublished - 4 Nov 2005

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