Inhibition of Nitric-Oxide Synthesis Leads to Reduced Parasitemia in Murine Trypanosoma-Brucei Infection

Jeremy M Sternberg, N Mabbott, I Sutherland, F Y Liew

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58 Citations (Scopus)

Abstract

In murine Trypanosoma brucei infection, macrophage activation and nitric oxide (NO) production lead to suppressed splenic T-cell responses (J. Sternberg and F. McGuigan, Eur. J. Immunol. 22:2741-2744, 1992). In this study, evidence is presented that NO has no detectable trypanocidal activity under simulated in vivo conditions and that inhibition of NO production in vivo results in reduced parasitemia.

Original languageEnglish
Pages (from-to)2135-2137
Number of pages3
JournalInfection and Immunity
Volume62
Issue number5
Publication statusPublished - May 1994

Keywords

  • T-CELL RESPONSES
  • L-ARGININE
  • MACROPHAGES
  • IMMUNOSUPPRESSION
  • SUPPRESSION
  • GAMBIENSE

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