Inhibition of Nitric-Oxide Synthesis Leads to Reduced Parasitemia in Murine Trypanosoma-Brucei Infection

Jeremy M Sternberg; N  Mabbott; I  Sutherland; F Y  Liew

Inhibition of Nitric-Oxide Synthesis Leads to Reduced Parasitemia in Murine Trypanosoma-Brucei Infection

Jeremy M Sternberg, N Mabbott, I Sutherland, F Y Liew

Aberdeen Centre For Environmental Sustainability

Research output: Contribution to journal › Comment/debate › peer-review

65 Citations (Scopus)

Abstract

In murine Trypanosoma brucei infection, macrophage activation and nitric oxide (NO) production lead to suppressed splenic T-cell responses (J. Sternberg and F. McGuigan, Eur. J. Immunol. 22:2741-2744, 1992). In this study, evidence is presented that NO has no detectable trypanocidal activity under simulated in vivo conditions and that inhibition of NO production in vivo results in reduced parasitemia.

Original language	English
Pages (from-to)	2135-2137
Number of pages	3
Journal	Infection and Immunity
Volume	62
Issue number	5
Publication status	Published - May 1994

Keywords

T-CELL RESPONSES
L-ARGININE
MACROPHAGES
IMMUNOSUPPRESSION
SUPPRESSION
GAMBIENSE

Cite this

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title = "Inhibition of Nitric-Oxide Synthesis Leads to Reduced Parasitemia in Murine Trypanosoma-Brucei Infection",

abstract = "In murine Trypanosoma brucei infection, macrophage activation and nitric oxide (NO) production lead to suppressed splenic T-cell responses (J. Sternberg and F. McGuigan, Eur. J. Immunol. 22:2741-2744, 1992). In this study, evidence is presented that NO has no detectable trypanocidal activity under simulated in vivo conditions and that inhibition of NO production in vivo results in reduced parasitemia.",

keywords = "T-CELL RESPONSES, L-ARGININE, MACROPHAGES, IMMUNOSUPPRESSION, SUPPRESSION, GAMBIENSE",

author = "Sternberg, {Jeremy M} and N Mabbott and I Sutherland and Liew, {F Y}",

year = "1994",

month = may,

language = "English",

volume = "62",

pages = "2135--2137",

journal = "Infection and Immunity",

issn = "0019-9567",

publisher = "American Society for Microbiology",

number = "5",

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TY - JOUR

T1 - Inhibition of Nitric-Oxide Synthesis Leads to Reduced Parasitemia in Murine Trypanosoma-Brucei Infection

AU - Sternberg, Jeremy M

AU - Mabbott, N

AU - Sutherland, I

AU - Liew, F Y

PY - 1994/5

Y1 - 1994/5

N2 - In murine Trypanosoma brucei infection, macrophage activation and nitric oxide (NO) production lead to suppressed splenic T-cell responses (J. Sternberg and F. McGuigan, Eur. J. Immunol. 22:2741-2744, 1992). In this study, evidence is presented that NO has no detectable trypanocidal activity under simulated in vivo conditions and that inhibition of NO production in vivo results in reduced parasitemia.

AB - In murine Trypanosoma brucei infection, macrophage activation and nitric oxide (NO) production lead to suppressed splenic T-cell responses (J. Sternberg and F. McGuigan, Eur. J. Immunol. 22:2741-2744, 1992). In this study, evidence is presented that NO has no detectable trypanocidal activity under simulated in vivo conditions and that inhibition of NO production in vivo results in reduced parasitemia.

KW - T-CELL RESPONSES

KW - L-ARGININE

KW - MACROPHAGES

KW - IMMUNOSUPPRESSION

KW - SUPPRESSION

KW - GAMBIENSE

M3 - Comment/debate

SN - 0019-9567

VL - 62

SP - 2135

EP - 2137

JO - Infection and Immunity

JF - Infection and Immunity

IS - 5

ER -

Inhibition of Nitric-Oxide Synthesis Leads to Reduced Parasitemia in Murine Trypanosoma-Brucei Infection

Abstract

Keywords

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