Inhibition of Nitric-Oxide Synthesis Leads to Reduced Parasitemia in Murine Trypanosoma-Brucei Infection

Jeremy M Sternberg, N Mabbott, I Sutherland, F Y Liew

Research output: Contribution to journalComment/debate

57 Citations (Scopus)

Abstract

In murine Trypanosoma brucei infection, macrophage activation and nitric oxide (NO) production lead to suppressed splenic T-cell responses (J. Sternberg and F. McGuigan, Eur. J. Immunol. 22:2741-2744, 1992). In this study, evidence is presented that NO has no detectable trypanocidal activity under simulated in vivo conditions and that inhibition of NO production in vivo results in reduced parasitemia.

Original languageEnglish
Pages (from-to)2135-2137
Number of pages3
JournalInfection and Immunity
Volume62
Issue number5
Publication statusPublished - May 1994

Keywords

  • T-CELL RESPONSES
  • L-ARGININE
  • MACROPHAGES
  • IMMUNOSUPPRESSION
  • SUPPRESSION
  • GAMBIENSE

Cite this

Inhibition of Nitric-Oxide Synthesis Leads to Reduced Parasitemia in Murine Trypanosoma-Brucei Infection. / Sternberg, Jeremy M; Mabbott, N ; Sutherland, I ; Liew, F Y .

In: Infection and Immunity, Vol. 62, No. 5, 05.1994, p. 2135-2137.

Research output: Contribution to journalComment/debate

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abstract = "In murine Trypanosoma brucei infection, macrophage activation and nitric oxide (NO) production lead to suppressed splenic T-cell responses (J. Sternberg and F. McGuigan, Eur. J. Immunol. 22:2741-2744, 1992). In this study, evidence is presented that NO has no detectable trypanocidal activity under simulated in vivo conditions and that inhibition of NO production in vivo results in reduced parasitemia.",
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T1 - Inhibition of Nitric-Oxide Synthesis Leads to Reduced Parasitemia in Murine Trypanosoma-Brucei Infection

AU - Sternberg, Jeremy M

AU - Mabbott, N

AU - Sutherland, I

AU - Liew, F Y

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N2 - In murine Trypanosoma brucei infection, macrophage activation and nitric oxide (NO) production lead to suppressed splenic T-cell responses (J. Sternberg and F. McGuigan, Eur. J. Immunol. 22:2741-2744, 1992). In this study, evidence is presented that NO has no detectable trypanocidal activity under simulated in vivo conditions and that inhibition of NO production in vivo results in reduced parasitemia.

AB - In murine Trypanosoma brucei infection, macrophage activation and nitric oxide (NO) production lead to suppressed splenic T-cell responses (J. Sternberg and F. McGuigan, Eur. J. Immunol. 22:2741-2744, 1992). In this study, evidence is presented that NO has no detectable trypanocidal activity under simulated in vivo conditions and that inhibition of NO production in vivo results in reduced parasitemia.

KW - T-CELL RESPONSES

KW - L-ARGININE

KW - MACROPHAGES

KW - IMMUNOSUPPRESSION

KW - SUPPRESSION

KW - GAMBIENSE

M3 - Comment/debate

VL - 62

SP - 2135

EP - 2137

JO - Infection and Immunity

JF - Infection and Immunity

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