Inhibition of simian immunodeficiency virus (SIV) replication by CD8 + cells of SIV‐infected rhesus macaques: Implications for immunopathogenesis

David J. Blackbourn, Linda F. Chuang*, Keith F. Killam, Ronald Y. Chuang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

The ability of the CD8 + cells from simian immunodeficiency virus (SIV)‐infected rhesus macaques to inhibit SIV replication was investigated. Inhibition was produced by a heat‐stable soluble factor of molecular size greater than 10kDa. CD8 + supernatants from some macaques were found not only to suppress SIV growth but also to be cytolytic toward both infected and uninfected CD4+ cells. Such indiscriminate CD8 + cell‐mediated cell killing may therefore account for DC4 + cell depletion in certain SIV‐infected macaques. 1994 Munksgaard

Original languageEnglish
Pages (from-to)343-354
Number of pages12
JournalJournal of Medical Primatology
Volume23
Issue number6
DOIs
Publication statusPublished - Aug 1994

Keywords

  • CD8 + suppressor
  • Macaca mulatta
  • SIVmac infection
  • target cell lysis

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