Inhibition of simian immunodeficiency virus (SIV) replication by CD8 + cells of SIV‐infected rhesus macaques: Implications for immunopathogenesis

David J. Blackbourn; Linda F. Chuang; Keith F. Killam; Ronald Y. Chuang

doi:10.1111/j.1600-0684.1994.tb00297.x

Inhibition of simian immunodeficiency virus (SIV) replication by CD8 + cells of SIV‐infected rhesus macaques: Implications for immunopathogenesis

David J. Blackbourn, Linda F. Chuang^*, Keith F. Killam, Ronald Y. Chuang

^*Corresponding author for this work

Medical Sciences

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

The ability of the CD8 + cells from simian immunodeficiency virus (SIV)‐infected rhesus macaques to inhibit SIV replication was investigated. Inhibition was produced by a heat‐stable soluble factor of molecular size greater than 10kDa. CD8 + supernatants from some macaques were found not only to suppress SIV growth but also to be cytolytic toward both infected and uninfected CD4+ cells. Such indiscriminate CD8 + cell‐mediated cell killing may therefore account for DC4 + cell depletion in certain SIV‐infected macaques. 1994 Munksgaard

Original language	English
Pages (from-to)	343-354
Number of pages	12
Journal	Journal of Medical Primatology
Volume	23
Issue number	6
DOIs	https://doi.org/10.1111/j.1600-0684.1994.tb00297.x
Publication status	Published - Aug 1994

Keywords

CD8 + suppressor
Macaca mulatta
SIVmac infection
target cell lysis

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10.1111/j.1600-0684.1994.tb00297.x

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abstract = "The ability of the CD8 + cells from simian immunodeficiency virus (SIV)‐infected rhesus macaques to inhibit SIV replication was investigated. Inhibition was produced by a heat‐stable soluble factor of molecular size greater than 10kDa. CD8 + supernatants from some macaques were found not only to suppress SIV growth but also to be cytolytic toward both infected and uninfected CD4+ cells. Such indiscriminate CD8 + cell‐mediated cell killing may therefore account for DC4 + cell depletion in certain SIV‐infected macaques. 1994 Munksgaard",

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AU - Killam, Keith F.

AU - Chuang, Ronald Y.

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AB - The ability of the CD8 + cells from simian immunodeficiency virus (SIV)‐infected rhesus macaques to inhibit SIV replication was investigated. Inhibition was produced by a heat‐stable soluble factor of molecular size greater than 10kDa. CD8 + supernatants from some macaques were found not only to suppress SIV growth but also to be cytolytic toward both infected and uninfected CD4+ cells. Such indiscriminate CD8 + cell‐mediated cell killing may therefore account for DC4 + cell depletion in certain SIV‐infected macaques. 1994 Munksgaard

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Inhibition of simian immunodeficiency virus (SIV) replication by CD8 + cells of SIV‐infected rhesus macaques: Implications for immunopathogenesis

Abstract

Keywords

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