Abstract
The ability of the CD8 + cells from simian immunodeficiency virus (SIV)‐infected rhesus macaques to inhibit SIV replication was investigated. Inhibition was produced by a heat‐stable soluble factor of molecular size greater than 10kDa. CD8 + supernatants from some macaques were found not only to suppress SIV growth but also to be cytolytic toward both infected and uninfected CD4+ cells. Such indiscriminate CD8 + cell‐mediated cell killing may therefore account for DC4 + cell depletion in certain SIV‐infected macaques. 1994 Munksgaard
Original language | English |
---|---|
Pages (from-to) | 343-354 |
Number of pages | 12 |
Journal | Journal of Medical Primatology |
Volume | 23 |
Issue number | 6 |
DOIs | |
Publication status | Published - Aug 1994 |
Keywords
- CD8 + suppressor
- Macaca mulatta
- SIVmac infection
- target cell lysis