Inhibition of the contraction of collagen gels by extracts from human dermis

M. A. El-Sheemy, I. F. Muir, Denis Wheatley, O. Eremin

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    Abstract

    Extracts from the human dermis were prepared and evaluated with respect to their ability to influence fibroblasts to contract collagen gels in vitro. The extract which had the most inhibitory effect on fibroblasts to cause contraction of collagen gels was extract D. It also inhibited fibroblast growth. Inhibition of contraction was not simply related to fibroblast cell numbers and the data suggests a specific effect upon the ability of fibroblasts to cause contraction. Other extracts were without significant effect. (C) 2001 Academic Press.

    Original languageEnglish
    Pages (from-to)635-642
    Number of pages7
    JournalCell Biology International
    Volume25
    Issue number7
    DOIs
    Publication statusPublished - 2001

    Keywords

    • proteoglycans
    • DSPG II
    • collagen gels
    • fibroblasts
    • contraction
    • wound healing
    • DYSTROPHICA RECESSIVE FIBROBLASTS
    • HUMAN-SKIN FIBROBLASTS
    • LATTICE CONTRACTION
    • WOUND CONTRACTION
    • INVITRO
    • MATRICES
    • BEHAVIOR

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