Inhibition of the contraction of collagen gels by extracts from human dermis

M. A. El-Sheemy, I. F. Muir, Denis Wheatley, O. Eremin

    Research output: Contribution to journalArticle

    5 Citations (Scopus)

    Abstract

    Extracts from the human dermis were prepared and evaluated with respect to their ability to influence fibroblasts to contract collagen gels in vitro. The extract which had the most inhibitory effect on fibroblasts to cause contraction of collagen gels was extract D. It also inhibited fibroblast growth. Inhibition of contraction was not simply related to fibroblast cell numbers and the data suggests a specific effect upon the ability of fibroblasts to cause contraction. Other extracts were without significant effect. (C) 2001 Academic Press.

    Original languageEnglish
    Pages (from-to)635-642
    Number of pages7
    JournalCell Biology International
    Volume25
    Issue number7
    DOIs
    Publication statusPublished - 2001

    Keywords

    • proteoglycans
    • DSPG II
    • collagen gels
    • fibroblasts
    • contraction
    • wound healing
    • DYSTROPHICA RECESSIVE FIBROBLASTS
    • HUMAN-SKIN FIBROBLASTS
    • LATTICE CONTRACTION
    • WOUND CONTRACTION
    • INVITRO
    • MATRICES
    • BEHAVIOR

    Cite this

    Inhibition of the contraction of collagen gels by extracts from human dermis. / El-Sheemy, M. A.; Muir, I. F.; Wheatley, Denis; Eremin, O.

    In: Cell Biology International, Vol. 25, No. 7, 2001, p. 635-642.

    Research output: Contribution to journalArticle

    El-Sheemy, M. A. ; Muir, I. F. ; Wheatley, Denis ; Eremin, O. / Inhibition of the contraction of collagen gels by extracts from human dermis. In: Cell Biology International. 2001 ; Vol. 25, No. 7. pp. 635-642.
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    abstract = "Extracts from the human dermis were prepared and evaluated with respect to their ability to influence fibroblasts to contract collagen gels in vitro. The extract which had the most inhibitory effect on fibroblasts to cause contraction of collagen gels was extract D. It also inhibited fibroblast growth. Inhibition of contraction was not simply related to fibroblast cell numbers and the data suggests a specific effect upon the ability of fibroblasts to cause contraction. Other extracts were without significant effect. (C) 2001 Academic Press.",
    keywords = "proteoglycans, DSPG II, collagen gels, fibroblasts, contraction, wound healing, DYSTROPHICA RECESSIVE FIBROBLASTS, HUMAN-SKIN FIBROBLASTS, LATTICE CONTRACTION, WOUND CONTRACTION, INVITRO, MATRICES, BEHAVIOR",
    author = "El-Sheemy, {M. A.} and Muir, {I. F.} and Denis Wheatley and O. Eremin",
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    T1 - Inhibition of the contraction of collagen gels by extracts from human dermis

    AU - El-Sheemy, M. A.

    AU - Muir, I. F.

    AU - Wheatley, Denis

    AU - Eremin, O.

    PY - 2001

    Y1 - 2001

    N2 - Extracts from the human dermis were prepared and evaluated with respect to their ability to influence fibroblasts to contract collagen gels in vitro. The extract which had the most inhibitory effect on fibroblasts to cause contraction of collagen gels was extract D. It also inhibited fibroblast growth. Inhibition of contraction was not simply related to fibroblast cell numbers and the data suggests a specific effect upon the ability of fibroblasts to cause contraction. Other extracts were without significant effect. (C) 2001 Academic Press.

    AB - Extracts from the human dermis were prepared and evaluated with respect to their ability to influence fibroblasts to contract collagen gels in vitro. The extract which had the most inhibitory effect on fibroblasts to cause contraction of collagen gels was extract D. It also inhibited fibroblast growth. Inhibition of contraction was not simply related to fibroblast cell numbers and the data suggests a specific effect upon the ability of fibroblasts to cause contraction. Other extracts were without significant effect. (C) 2001 Academic Press.

    KW - proteoglycans

    KW - DSPG II

    KW - collagen gels

    KW - fibroblasts

    KW - contraction

    KW - wound healing

    KW - DYSTROPHICA RECESSIVE FIBROBLASTS

    KW - HUMAN-SKIN FIBROBLASTS

    KW - LATTICE CONTRACTION

    KW - WOUND CONTRACTION

    KW - INVITRO

    KW - MATRICES

    KW - BEHAVIOR

    U2 - 10.1006/cbir.2000.0694

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    JO - Cell Biology International

    JF - Cell Biology International

    SN - 1065-6995

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    ER -