Inhibitory C-type lectin receptors in myeloid cells

Pierre Redelinghuys, Gordon D Brown

Research output: Contribution to journalArticle

28 Citations (Scopus)
5 Downloads (Pure)

Abstract

C-type lectin receptors encoded by the natural killer gene complex play critical roles in enabling NK cell discrimination between self and non-self. In recent years, additional genes at this locus have been identified with patterns of expression that extend to cells of the myeloid lineage where many of the encoded inhibitory receptors have equally important functions as regulators of immune homeostasis. In the present review we highlight the roles of some of these receptors including recent insights gained with regard to the identification of exogenous and endogenous ligands, mechanisms of cellular inhibition and activation, regulated expression within different cellular and immune contexts, as well as functions that include the regulation of bone homeostasis and involvement in autoimmunity.
Original languageEnglish
Pages (from-to)1-12
Number of pages12
JournalImmunology Letters
Volume136
Issue number1
Early online date8 Oct 2010
DOIs
Publication statusPublished - 30 Apr 2011

Fingerprint

C-Type Lectins
Myeloid Cells
Homeostasis
Cell Lineage
Autoimmunity
Natural Killer Cells
Genes
Ligands
Bone and Bones

Keywords

  • animals
  • dendritic cells
  • humans
  • killer cells, natural
  • lectins, C-type
  • ligands
  • myeloid cells
  • osteoclasts

Cite this

Inhibitory C-type lectin receptors in myeloid cells. / Redelinghuys, Pierre; Brown, Gordon D.

In: Immunology Letters, Vol. 136, No. 1, 30.04.2011, p. 1-12.

Research output: Contribution to journalArticle

Redelinghuys, Pierre ; Brown, Gordon D. / Inhibitory C-type lectin receptors in myeloid cells. In: Immunology Letters. 2011 ; Vol. 136, No. 1. pp. 1-12.
@article{9b7221fa41cb4f7bbf0d9623647db4e3,
title = "Inhibitory C-type lectin receptors in myeloid cells",
abstract = "C-type lectin receptors encoded by the natural killer gene complex play critical roles in enabling NK cell discrimination between self and non-self. In recent years, additional genes at this locus have been identified with patterns of expression that extend to cells of the myeloid lineage where many of the encoded inhibitory receptors have equally important functions as regulators of immune homeostasis. In the present review we highlight the roles of some of these receptors including recent insights gained with regard to the identification of exogenous and endogenous ligands, mechanisms of cellular inhibition and activation, regulated expression within different cellular and immune contexts, as well as functions that include the regulation of bone homeostasis and involvement in autoimmunity.",
keywords = "animals, dendritic cells, humans, killer cells, natural, lectins, C-type, ligands, myeloid cells, osteoclasts",
author = "Pierre Redelinghuys and Brown, {Gordon D}",
note = "Copyright {\circledC} 2010 Elsevier B.V. All rights reserved.",
year = "2011",
month = "4",
day = "30",
doi = "10.1016/j.imlet.2010.10.005",
language = "English",
volume = "136",
pages = "1--12",
journal = "Immunology Letters",
issn = "0165-2478",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - Inhibitory C-type lectin receptors in myeloid cells

AU - Redelinghuys, Pierre

AU - Brown, Gordon D

N1 - Copyright © 2010 Elsevier B.V. All rights reserved.

PY - 2011/4/30

Y1 - 2011/4/30

N2 - C-type lectin receptors encoded by the natural killer gene complex play critical roles in enabling NK cell discrimination between self and non-self. In recent years, additional genes at this locus have been identified with patterns of expression that extend to cells of the myeloid lineage where many of the encoded inhibitory receptors have equally important functions as regulators of immune homeostasis. In the present review we highlight the roles of some of these receptors including recent insights gained with regard to the identification of exogenous and endogenous ligands, mechanisms of cellular inhibition and activation, regulated expression within different cellular and immune contexts, as well as functions that include the regulation of bone homeostasis and involvement in autoimmunity.

AB - C-type lectin receptors encoded by the natural killer gene complex play critical roles in enabling NK cell discrimination between self and non-self. In recent years, additional genes at this locus have been identified with patterns of expression that extend to cells of the myeloid lineage where many of the encoded inhibitory receptors have equally important functions as regulators of immune homeostasis. In the present review we highlight the roles of some of these receptors including recent insights gained with regard to the identification of exogenous and endogenous ligands, mechanisms of cellular inhibition and activation, regulated expression within different cellular and immune contexts, as well as functions that include the regulation of bone homeostasis and involvement in autoimmunity.

KW - animals

KW - dendritic cells

KW - humans

KW - killer cells, natural

KW - lectins, C-type

KW - ligands

KW - myeloid cells

KW - osteoclasts

U2 - 10.1016/j.imlet.2010.10.005

DO - 10.1016/j.imlet.2010.10.005

M3 - Article

C2 - 20934454

VL - 136

SP - 1

EP - 12

JO - Immunology Letters

JF - Immunology Letters

SN - 0165-2478

IS - 1

ER -