Inhibitory effect of Ginkgo biloba extract on human platelet aggregation

A.K. Dutta-Roy, M.J. Gordon, C. Kelly, K. Hunter, L. Crosbie, T. Knight-Carpentar, B.C. Williams

Research output: Contribution to journalArticle

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Abstract

The effect of pure flavonoids and Gingko biloba extract (GBE) on human platelet aggregation was investigated. Most of the flavonoids and vitamin E did not affect platelet aggregation in platelet-rich plasma (PRP); however some of these flavonoids inhibited platelet aggregation in gel-filtered platelets (GFP). GBE inhibited both ADP-and collagen-induced platelet aggregation in PRP, GFP and in whole blood in a dose-dependent manner. GBE at very low concentrations inhibited whole blood aggregation induced by ADP compared with those used for PRP or GFP. Flavonoids and GBE decreased the production of TxA induced by collagen and ADP in PRP. However, no correlation was observed between the inhibition of platelet aggregation and the decrease of TxA synthesis. GBE and flavonoids did not affect platelet membrane fluidity. However, the incubation of PRP with GBE increased cAMP levels in platelets, which is known to inhibit platelet activation by lowering intracellular Ca levels. GBE is a mixture of many compounds, including flavonoids and gingkoglides, which affect metabolism of cAMP, TxA and Ca in platelets. It is effective in the inhibition of platelet aggregation, both in PRP and whole blood, and thus may be potentially used as an effective oral anti-platelet therapeutic agent.
Original languageEnglish
Pages (from-to)298-305
Number of pages8
JournalPlatelets
Volume10
Issue number5
DOIs
Publication statusPublished - 1 Jan 1999

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Ginkgo biloba
Platelet-Rich Plasma
Platelet Aggregation
Flavonoids
Blood Platelets
Adenosine Diphosphate
Gels
Collagen
Membrane Fluidity
Platelet Activation
Vitamin E

Cite this

Dutta-Roy, A. K., Gordon, M. J., Kelly, C., Hunter, K., Crosbie, L., Knight-Carpentar, T., & Williams, B. C. (1999). Inhibitory effect of Ginkgo biloba extract on human platelet aggregation. Platelets, 10(5), 298-305. https://doi.org/10.1080/09537109975933

Inhibitory effect of Ginkgo biloba extract on human platelet aggregation. / Dutta-Roy, A.K.; Gordon, M.J.; Kelly, C.; Hunter, K.; Crosbie, L.; Knight-Carpentar, T.; Williams, B.C.

In: Platelets, Vol. 10, No. 5, 01.01.1999, p. 298-305.

Research output: Contribution to journalArticle

Dutta-Roy, AK, Gordon, MJ, Kelly, C, Hunter, K, Crosbie, L, Knight-Carpentar, T & Williams, BC 1999, 'Inhibitory effect of Ginkgo biloba extract on human platelet aggregation', Platelets, vol. 10, no. 5, pp. 298-305. https://doi.org/10.1080/09537109975933
Dutta-Roy AK, Gordon MJ, Kelly C, Hunter K, Crosbie L, Knight-Carpentar T et al. Inhibitory effect of Ginkgo biloba extract on human platelet aggregation. Platelets. 1999 Jan 1;10(5):298-305. https://doi.org/10.1080/09537109975933
Dutta-Roy, A.K. ; Gordon, M.J. ; Kelly, C. ; Hunter, K. ; Crosbie, L. ; Knight-Carpentar, T. ; Williams, B.C. / Inhibitory effect of Ginkgo biloba extract on human platelet aggregation. In: Platelets. 1999 ; Vol. 10, No. 5. pp. 298-305.
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