Innate defense against fungal pathogens

Rebecca A Drummond, Sarah L Gaffen, Amy G Hise, Gordon D Brown

Research output: Contribution to journalArticlepeer-review

45 Citations (Scopus)

Abstract

Human fungal infections have been on the rise in recent years and proved increasingly difficult to treat as a result of the lack of diagnostics, effective antifungal therapies, and vaccines. Most pathogenic fungi do not cause disease unless there is a disturbance in immune homeostasis, which can be caused by modern medical interventions, disease-induced immunosuppression, and naturally occurring human mutations. The innate immune system is well equipped to recognize and destroy pathogenic fungi through specialized cells expressing a broad range of pattern recognition receptors (PRRs). This review will outline the cells and PRRs required for effective antifungal immunity, with a special focus on the major antifungal cytokine IL-17 and recently characterized antifungal inflammasomes.

Original languageEnglish
Article numbera0119620
JournalCold Spring Harbor perspectives in medicine
Volume5
Issue number6
DOIs
Publication statusPublished - 10 Nov 2014

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