Innate immune sensors and gastrointestinal bacterial infections

Georgina L Hold, Indrani Mukhopadhya, Tom P Monie

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The gastrointestinal microbiota is a major source of immune stimulation. The interaction between host pattern-recognition receptors and conserved microbial ligands profoundly influences infection dynamics. Identifying and understanding the nature of these interactions is a key step towards obtaining a clearer picture of microbial pathogenesis. These interactions underpin a complex interplay between microbe and host that has far reaching consequences for both. Here, we review the role of pattern recognition receptors in three prototype diseases affecting the stomach, the small intestine, and large intestine, respectively (Helicobacter pylori infection, Salmonella infection, and inflammatory bowel disease). Specifically, we review the nature and impact of pathogen:receptor interactions, their impact upon pathogenesis, and address the relevance of pattern recognition receptors in the development of therapies for gastrointestinal diseases.
Original languageEnglish
Article number579650
Number of pages11
JournalClinical & Developmental Immunology
Volume2011
Early online date19 May 2011
DOIs
Publication statusPublished - 2011

Keywords

  • Animals
  • Bacterial Infections
  • Gastrointestinal Diseases
  • Gastrointestinal Tract
  • Helicobacter Infections
  • Humans
  • Immunity, Innate
  • Inflammatory Bowel Diseases
  • Receptors, Pattern Recognition
  • Salmonella Infections
  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Review
  • innate immune receptors, bacterial infections, gastrointestinal tract

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