Inside Cover: The Catalytic Mechanism of the Marine-Derived Macrocyclase PatGmac (Chem. Eur. J. 37/2016)

Natércia F. Brás, Pedro Ferreira, Ana R. Calixto, Marcel Jaspars, Wael Houssen, James H. Naismith, Pedro A. Fernandes, Maria J. Ramos*

*Corresponding author for this work

Research output: Contribution to journalArticle


Cyclic peptides are a class of compounds with high therapeutic potential. They possess very promising bioactivities, such as antitumor and antiviral (including anti-HIV) activity. However, effective production of these compounds by synthetic approaches have not been achieved to date, which motivates the study of biological methods of macrocyclization of peptides.
Original languageEnglish
Pages (from-to)12946
Number of pages1
JournalChemistry : a European Journal
Issue number37
Early online date16 Aug 2016
Publication statusPublished - 5 Sep 2016



  • cyclization
  • molecular mechanics
  • peptides
  • quantum mechanics
  • reaction mechanisms

ASJC Scopus subject areas

  • Chemistry(all)

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