Inside Cover: The Catalytic Mechanism of the Marine-Derived Macrocyclase PatGmac (Chem. Eur. J. 37/2016)

Natércia F. Brás; Pedro Ferreira; Ana R. Calixto; Marcel Jaspars; Wael Houssen; James H. Naismith; Pedro A. Fernandes; Maria J. Ramos

doi:10.1002/chem.201603742

Inside Cover: The Catalytic Mechanism of the Marine-Derived Macrocyclase PatGmac (Chem. Eur. J. 37/2016)

Natércia F. Brás, Pedro Ferreira, Ana R. Calixto, Marcel Jaspars, Wael Houssen, James H. Naismith, Pedro A. Fernandes, Maria J. Ramos^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Cyclic peptides are a class of compounds with high therapeutic potential. They possess very promising bioactivities, such as antitumor and antiviral (including anti-HIV) activity. However, effective production of these compounds by synthetic approaches have not been achieved to date, which motivates the study of biological methods of macrocyclization of peptides.

Original language	English
Pages (from-to)	12946
Number of pages	1
Journal	Chemistry : a European Journal
Volume	22
Issue number	37
Early online date	16 Aug 2016
DOIs	https://doi.org/10.1002/chem.201603742
Publication status	Published - 5 Sep 2016

Keywords

cyclization
molecular mechanics
peptides
quantum mechanics
reaction mechanisms

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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abstract = "Cyclic peptides are a class of compounds with high therapeutic potential. They possess very promising bioactivities, such as antitumor and antiviral (including anti-HIV) activity. However, effective production of these compounds by synthetic approaches have not been achieved to date, which motivates the study of biological methods of macrocyclization of peptides.",

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AU - Brás, Natércia F.

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AU - Calixto, Ana R.

AU - Jaspars, Marcel

AU - Houssen, Wael

AU - Naismith, James H.

AU - Fernandes, Pedro A.

AU - Ramos, Maria J.

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N2 - Cyclic peptides are a class of compounds with high therapeutic potential. They possess very promising bioactivities, such as antitumor and antiviral (including anti-HIV) activity. However, effective production of these compounds by synthetic approaches have not been achieved to date, which motivates the study of biological methods of macrocyclization of peptides.

AB - Cyclic peptides are a class of compounds with high therapeutic potential. They possess very promising bioactivities, such as antitumor and antiviral (including anti-HIV) activity. However, effective production of these compounds by synthetic approaches have not been achieved to date, which motivates the study of biological methods of macrocyclization of peptides.

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KW - molecular mechanics

KW - peptides

KW - quantum mechanics

KW - reaction mechanisms

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Inside Cover: The Catalytic Mechanism of the Marine-Derived Macrocyclase PatGmac (Chem. Eur. J. 37/2016)

Abstract

Keywords

UN SDGs

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