Cyclic peptides are a class of compounds with high therapeutic potential. They possess very promising bioactivities, such as antitumor and antiviral (including anti-HIV) activity. However, effective production of these compounds by synthetic approaches have not been achieved to date, which motivates the study of biological methods of macrocyclization of peptides.
- molecular mechanics
- quantum mechanics
- reaction mechanisms
ASJC Scopus subject areas
Brás, N. F., Ferreira, P., Calixto, A. R., Jaspars, M., Houssen, W., Naismith, J. H., ... Ramos, M. J. (2016). Inside Cover: The Catalytic Mechanism of the Marine-Derived Macrocyclase PatGmac (Chem. Eur. J. 37/2016). Chemistry : a European Journal, 22(37), 12946. https://doi.org/10.1002/chem.201603742