Insulin is a Two-Edged Knife on the Brain

Susana Cardoso, Sonia Correia, Renato X Santos, Cristina Carvalho, Maria S Santos, Catarina R Oliveira, George Perry, Mark A Smith, Xiongwei Zhu, Paula I Moreira (Corresponding Author)

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Insulin, long known as an important regulator of blood glucose levels, plays important and multifaceted roles in the brain. It has been reported that insulin is an important neuromodulator, contributing to several neurobiological processes in particular energy homeostasis and cognition. Dysregulation of insulin signaling has been linked to aging and metabolic and neurodegenerative disorders. The first part of this review is devoted to discussion of the critical role of insulin signaling in normal brain function. Then the involvement of impaired insulin signaling in the pathophysiology of diabetes, Alzheimer's, Parkinson's and Huntington's diseases and amyotrophic lateral sclerosis will be discussed. Finally, the potential therapeutic effect of insulin and insulin sensitizers will be examined.

Original languageEnglish
Pages (from-to)483-507
Number of pages27
JournalJournal of Alzheimer's Disease
Volume18
Issue number3
DOIs
Publication statusPublished - 30 Oct 2009

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Insulin
Brain
Huntington Disease
Amyotrophic Lateral Sclerosis
Therapeutic Uses
Neurodegenerative Diseases
Cognition
Neurotransmitter Agents
Parkinson Disease
Blood Glucose
Alzheimer Disease
Homeostasis

Keywords

  • brain
  • insulin sensitizers
  • insulin
  • insulin signaling
  • neurodegenerative disorders

Cite this

Cardoso, S., Correia, S., Santos, R. X., Carvalho, C., Santos, M. S., Oliveira, C. R., ... Moreira, P. I. (2009). Insulin is a Two-Edged Knife on the Brain. Journal of Alzheimer's Disease, 18(3), 483-507. https://doi.org/10.3233/JAD-2009-1155

Insulin is a Two-Edged Knife on the Brain. / Cardoso, Susana; Correia, Sonia; Santos, Renato X; Carvalho, Cristina; Santos, Maria S; Oliveira, Catarina R; Perry, George ; Smith, Mark A; Zhu, Xiongwei; Moreira, Paula I (Corresponding Author).

In: Journal of Alzheimer's Disease, Vol. 18, No. 3, 30.10.2009, p. 483-507.

Research output: Contribution to journalArticle

Cardoso, S, Correia, S, Santos, RX, Carvalho, C, Santos, MS, Oliveira, CR, Perry, G, Smith, MA, Zhu, X & Moreira, PI 2009, 'Insulin is a Two-Edged Knife on the Brain', Journal of Alzheimer's Disease, vol. 18, no. 3, pp. 483-507. https://doi.org/10.3233/JAD-2009-1155
Cardoso S, Correia S, Santos RX, Carvalho C, Santos MS, Oliveira CR et al. Insulin is a Two-Edged Knife on the Brain. Journal of Alzheimer's Disease. 2009 Oct 30;18(3):483-507. https://doi.org/10.3233/JAD-2009-1155
Cardoso, Susana ; Correia, Sonia ; Santos, Renato X ; Carvalho, Cristina ; Santos, Maria S ; Oliveira, Catarina R ; Perry, George ; Smith, Mark A ; Zhu, Xiongwei ; Moreira, Paula I. / Insulin is a Two-Edged Knife on the Brain. In: Journal of Alzheimer's Disease. 2009 ; Vol. 18, No. 3. pp. 483-507.
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