Abstract
Introduction: Colorectal cancer (CRC) is one of the commonest types of cancer that affects a significant proportion of the population and is a major contributor to cancer related mortality. The relatively poor survival rate of CRC could be improved through the identification of clinically useful biomarkers.
Area covered: This review highlights the need for biomarkers and discusses recent proteomics discoveries in the aspects of CRC clinical practice including diagnosis, prognosis, therapy, screening, and molecular pathological epidemiology (MPE). Studies have been evaluated in relation to biomarker target, methodology, sample selection, limitations, and potential impact. Finally, the progress in proteomic approaches is briefly discussed, and the main difficulties facing the translation of proteomics biomarkers into the clinical practice are highlighted.
Expert opinion: The establishment of specific guidelines, best practice recommendations and the improvement in proteomic strategies will significantly improve the prospects for developing clinically useful biomarkers.
Area covered: This review highlights the need for biomarkers and discusses recent proteomics discoveries in the aspects of CRC clinical practice including diagnosis, prognosis, therapy, screening, and molecular pathological epidemiology (MPE). Studies have been evaluated in relation to biomarker target, methodology, sample selection, limitations, and potential impact. Finally, the progress in proteomic approaches is briefly discussed, and the main difficulties facing the translation of proteomics biomarkers into the clinical practice are highlighted.
Expert opinion: The establishment of specific guidelines, best practice recommendations and the improvement in proteomic strategies will significantly improve the prospects for developing clinically useful biomarkers.
| Original language | English |
|---|---|
| Pages (from-to) | 917-927 |
| Number of pages | 11 |
| Journal | Expert Review of Proteomics |
| Volume | 13 |
| Issue number | 10 |
| Early online date | 19 Sep 2016 |
| DOIs | |
| Publication status | Published - Oct 2016 |
Keywords
- Biomarkers
- colorectal cancer
- diagnosis
- prognosis
- proteomics
- predictive screening
- MOLECULAR PATHOLOGICAL EPIDEMIOLOGY
- URINARY PGE-M
- COLON-CANCER
- BIOMARKER DISCOVERY
- PRECISION MEDICINE
- PLASMA BIOMARKERS
- MASS-SPECTROMETRY
- TUMOR-MARKERS
- BIG DATA
- RISK
Access to Document
- Expert review of proteomics final accepted manuscript
This is an Accepted Manuscript of an article published by Taylor & Francis in Expert Review of Proteomics on 19 Sep 2016, available online: http://www.tandfonline.com/10.1080/14789450.2016.1233062