Inter-individual Variation in Cancer and Cardiometabolic Health Outcomes in Response to Coffee Consumption: a Critical Review

Edith Visser, Johanna M Geleijnse, Baukje de Roos* (Corresponding Author)

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)

Abstract

Scope

Coffee is associated with a lower risk of cancer, cardiovascular disease, and type 2 diabetes at the population level. However, individual susceptibility to the effects of coffee consumption will cause heterogeneity in health responses between individuals. In this critical review determinants of inter‐individual variability in cancer and cardiometabolic health outcomes in response to coffee and caffeine consumption are systematically evaluated.

Methods and results

Embase and MEDLINE are searched for observational studies and clinical trials that examined variation in the response to coffee consumption. A total of 74 studies meet the inclusion criteria, which report variation in cancer (n = 24) and cardiometabolic health (n = 50) outcomes. The qualitative analysis shows that sex, BMI, smoking, alcohol intake, menopausal status, and genetic polymorphisms are probable or possible determinants of inter‐individual variability in cancer and cardiometabolic health outcomes in response to coffee and caffeine consumption, albeit the majority of studies have insufficient statistical power to detect significant interaction between these factors and coffee consumption.

Conclusion

Several genetic and non‐genetic determinants of inter‐individual variability in the responses to coffee and caffeine consumption are identified, indicating that some of the health benefits of coffee may only occur in a subgroup of subjects.

Original languageEnglish
Article numbere1900479
Number of pages22
JournalMolecular Nutrition & Food Research
Volume64
Issue number7
Early online date4 Mar 2020
DOIs
Publication statusPublished - 1 Apr 2020

Keywords

  • Coffee
  • Caffeine
  • Inter-individual variation
  • Biological responsiveness
  • Nutrigenomics
  • caffeine
  • coffee
  • biological responsiveness
  • nutrigenomics
  • inter-individual variation
  • C-REACTIVE PROTEIN
  • JAPANESE MEN
  • MYOCARDIAL-INFARCTION
  • GAMMA-GLUTAMYL-TRANSFERASE
  • CHLOROGENIC ACIDS
  • POSTMENOPAUSAL BREAST-CANCER
  • GREEN TEA CONSUMPTION
  • 5178 C/A POLYMORPHISM
  • INSULIN-RESISTANCE
  • SERUM LIVER-ENZYMES

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