Interaction of metoprolol with lorazepam and bromazepam

A K Scott, G A Cameron, G M Hawksworth

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The interaction between metoprolol and bromazepam and lorazepam was studied in 12 healthy male volunteers aged 21-37 years. Metoprolol had no significant effect on the pharmacokinetics of bromazepam or lorazepam. However, bromazepam AUC was 35% higher in the presence of metoprolol. Bromazepam enhanced the effect of metoprolol on systolic blood pressure but not on diastolic blood pressure or pulse rate. Lorazepam had no effect on either blood pressure or pulse. Metoprolol did not enhance the effect of bromazepam on the psychomotor tests used in this study. Metoprolol caused a small increase in critical flicker fusion threshold with lorazepam but had no effect on the other tests. Lorazepam (2 mg) was more potent than bromazepam (6 mg) in the doses used in this study. The interaction of metoprolol with bromazepam and lorazepam is unlikely to be of clinical significance. No change in dose is necessary when using these drugs together.

Original languageEnglish
Pages (from-to)405-9
Number of pages5
JournalEuropean Journal of Clinical Pharmacology
Volume40
Issue number4
Publication statusPublished - 1991

Keywords

  • Administration, Oral
  • Adult
  • Blood Pressure
  • Bromazepam
  • Chromatography, High Pressure Liquid
  • Double-Blind Method
  • Drug Interactions
  • Humans
  • Lorazepam
  • Male
  • Metoprolol
  • Psychomotor Performance
  • Pulse
  • Random Allocation

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  • Cite this

    Scott, A. K., Cameron, G. A., & Hawksworth, G. M. (1991). Interaction of metoprolol with lorazepam and bromazepam. European Journal of Clinical Pharmacology, 40(4), 405-9.