Interaction of metoprolol with lorazepam and bromazepam

A K Scott, G A Cameron, G M Hawksworth

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The interaction between metoprolol and bromazepam and lorazepam was studied in 12 healthy male volunteers aged 21-37 years. Metoprolol had no significant effect on the pharmacokinetics of bromazepam or lorazepam. However, bromazepam AUC was 35% higher in the presence of metoprolol. Bromazepam enhanced the effect of metoprolol on systolic blood pressure but not on diastolic blood pressure or pulse rate. Lorazepam had no effect on either blood pressure or pulse. Metoprolol did not enhance the effect of bromazepam on the psychomotor tests used in this study. Metoprolol caused a small increase in critical flicker fusion threshold with lorazepam but had no effect on the other tests. Lorazepam (2 mg) was more potent than bromazepam (6 mg) in the doses used in this study. The interaction of metoprolol with bromazepam and lorazepam is unlikely to be of clinical significance. No change in dose is necessary when using these drugs together.

Original languageEnglish
Pages (from-to)405-9
Number of pages5
JournalEuropean Journal of Clinical Pharmacology
Volume40
Issue number4
Publication statusPublished - 1991

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Bromazepam
Lorazepam
Metoprolol
Blood Pressure
Flicker Fusion
Area Under Curve
Healthy Volunteers
Pharmacokinetics
Heart Rate

Keywords

  • Administration, Oral
  • Adult
  • Blood Pressure
  • Bromazepam
  • Chromatography, High Pressure Liquid
  • Double-Blind Method
  • Drug Interactions
  • Humans
  • Lorazepam
  • Male
  • Metoprolol
  • Psychomotor Performance
  • Pulse
  • Random Allocation

Cite this

Scott, A. K., Cameron, G. A., & Hawksworth, G. M. (1991). Interaction of metoprolol with lorazepam and bromazepam. European Journal of Clinical Pharmacology, 40(4), 405-9.

Interaction of metoprolol with lorazepam and bromazepam. / Scott, A K; Cameron, G A; Hawksworth, G M.

In: European Journal of Clinical Pharmacology, Vol. 40, No. 4, 1991, p. 405-9.

Research output: Contribution to journalArticle

Scott, AK, Cameron, GA & Hawksworth, GM 1991, 'Interaction of metoprolol with lorazepam and bromazepam' European Journal of Clinical Pharmacology, vol. 40, no. 4, pp. 405-9.
Scott, A K ; Cameron, G A ; Hawksworth, G M. / Interaction of metoprolol with lorazepam and bromazepam. In: European Journal of Clinical Pharmacology. 1991 ; Vol. 40, No. 4. pp. 405-9.
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abstract = "The interaction between metoprolol and bromazepam and lorazepam was studied in 12 healthy male volunteers aged 21-37 years. Metoprolol had no significant effect on the pharmacokinetics of bromazepam or lorazepam. However, bromazepam AUC was 35{\%} higher in the presence of metoprolol. Bromazepam enhanced the effect of metoprolol on systolic blood pressure but not on diastolic blood pressure or pulse rate. Lorazepam had no effect on either blood pressure or pulse. Metoprolol did not enhance the effect of bromazepam on the psychomotor tests used in this study. Metoprolol caused a small increase in critical flicker fusion threshold with lorazepam but had no effect on the other tests. Lorazepam (2 mg) was more potent than bromazepam (6 mg) in the doses used in this study. The interaction of metoprolol with bromazepam and lorazepam is unlikely to be of clinical significance. No change in dose is necessary when using these drugs together.",
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N2 - The interaction between metoprolol and bromazepam and lorazepam was studied in 12 healthy male volunteers aged 21-37 years. Metoprolol had no significant effect on the pharmacokinetics of bromazepam or lorazepam. However, bromazepam AUC was 35% higher in the presence of metoprolol. Bromazepam enhanced the effect of metoprolol on systolic blood pressure but not on diastolic blood pressure or pulse rate. Lorazepam had no effect on either blood pressure or pulse. Metoprolol did not enhance the effect of bromazepam on the psychomotor tests used in this study. Metoprolol caused a small increase in critical flicker fusion threshold with lorazepam but had no effect on the other tests. Lorazepam (2 mg) was more potent than bromazepam (6 mg) in the doses used in this study. The interaction of metoprolol with bromazepam and lorazepam is unlikely to be of clinical significance. No change in dose is necessary when using these drugs together.

AB - The interaction between metoprolol and bromazepam and lorazepam was studied in 12 healthy male volunteers aged 21-37 years. Metoprolol had no significant effect on the pharmacokinetics of bromazepam or lorazepam. However, bromazepam AUC was 35% higher in the presence of metoprolol. Bromazepam enhanced the effect of metoprolol on systolic blood pressure but not on diastolic blood pressure or pulse rate. Lorazepam had no effect on either blood pressure or pulse. Metoprolol did not enhance the effect of bromazepam on the psychomotor tests used in this study. Metoprolol caused a small increase in critical flicker fusion threshold with lorazepam but had no effect on the other tests. Lorazepam (2 mg) was more potent than bromazepam (6 mg) in the doses used in this study. The interaction of metoprolol with bromazepam and lorazepam is unlikely to be of clinical significance. No change in dose is necessary when using these drugs together.

KW - Administration, Oral

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KW - Drug Interactions

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