Interactions between commensal fungi and the C-type lectin receptor Dectin-1 influence colitis

Iliyan D Iliev, Vincent A Funari, Kent D Taylor, Quoclinh Nguyen, Christopher N Reyes, Samuel P Strom, Jordan Brown, Courtney A Becker, Phillip R Fleshner, Marla Dubinsky, Jerome I Rotter, Hanlin L Wang, Dermot P B McGovern, Gordon D Brown, David M Underhill

Research output: Contribution to journalArticle

455 Citations (Scopus)

Abstract

The intestinal microflora, typically equated with bacteria, influences diseases such as obesity and inflammatory bowel disease. Here, we show that the mammalian gut contains a rich fungal community that interacts with the immune system through the innate immune receptor Dectin-1. Mice lacking Dectin-1 exhibited increased susceptibility to chemically induced colitis, which was the result of altered responses to indigenous fungi. In humans, we identified a polymorphism in the gene for Dectin-1 (CLEC7A) that is strongly linked to a severe form of ulcerative colitis. Together, our findings reveal a eukaryotic fungal community in the gut (the "mycobiome") that coexists with bacteria and substantially expands the repertoire of organisms interacting with the intestinal immune system to influence health and disease.
Original languageEnglish
Pages (from-to)1314-1317
Number of pages4
JournalScience
Volume336
Issue number6086
Early online date6 Jun 2012
DOIs
Publication statusPublished - 8 Jun 2012

Fingerprint

C-Type Lectins
Colitis
Fungi
Immune System
Bacteria
Ulcerative Colitis
Inflammatory Bowel Diseases
Obesity
Health
Genes
dectin 1

Cite this

Iliev, I. D., Funari, V. A., Taylor, K. D., Nguyen, Q., Reyes, C. N., Strom, S. P., ... Underhill, D. M. (2012). Interactions between commensal fungi and the C-type lectin receptor Dectin-1 influence colitis. Science, 336(6086), 1314-1317. https://doi.org/10.1126/science.1221789

Interactions between commensal fungi and the C-type lectin receptor Dectin-1 influence colitis. / Iliev, Iliyan D; Funari, Vincent A; Taylor, Kent D; Nguyen, Quoclinh; Reyes, Christopher N; Strom, Samuel P; Brown, Jordan; Becker, Courtney A; Fleshner, Phillip R; Dubinsky, Marla; Rotter, Jerome I; Wang, Hanlin L; McGovern, Dermot P B; Brown, Gordon D; Underhill, David M.

In: Science, Vol. 336, No. 6086, 08.06.2012, p. 1314-1317.

Research output: Contribution to journalArticle

Iliev, ID, Funari, VA, Taylor, KD, Nguyen, Q, Reyes, CN, Strom, SP, Brown, J, Becker, CA, Fleshner, PR, Dubinsky, M, Rotter, JI, Wang, HL, McGovern, DPB, Brown, GD & Underhill, DM 2012, 'Interactions between commensal fungi and the C-type lectin receptor Dectin-1 influence colitis' Science, vol. 336, no. 6086, pp. 1314-1317. https://doi.org/10.1126/science.1221789
Iliev ID, Funari VA, Taylor KD, Nguyen Q, Reyes CN, Strom SP et al. Interactions between commensal fungi and the C-type lectin receptor Dectin-1 influence colitis. Science. 2012 Jun 8;336(6086):1314-1317. https://doi.org/10.1126/science.1221789
Iliev, Iliyan D ; Funari, Vincent A ; Taylor, Kent D ; Nguyen, Quoclinh ; Reyes, Christopher N ; Strom, Samuel P ; Brown, Jordan ; Becker, Courtney A ; Fleshner, Phillip R ; Dubinsky, Marla ; Rotter, Jerome I ; Wang, Hanlin L ; McGovern, Dermot P B ; Brown, Gordon D ; Underhill, David M. / Interactions between commensal fungi and the C-type lectin receptor Dectin-1 influence colitis. In: Science. 2012 ; Vol. 336, No. 6086. pp. 1314-1317.
@article{383550c17fc940c69e4e1efdf97d91e2,
title = "Interactions between commensal fungi and the C-type lectin receptor Dectin-1 influence colitis",
abstract = "The intestinal microflora, typically equated with bacteria, influences diseases such as obesity and inflammatory bowel disease. Here, we show that the mammalian gut contains a rich fungal community that interacts with the immune system through the innate immune receptor Dectin-1. Mice lacking Dectin-1 exhibited increased susceptibility to chemically induced colitis, which was the result of altered responses to indigenous fungi. In humans, we identified a polymorphism in the gene for Dectin-1 (CLEC7A) that is strongly linked to a severe form of ulcerative colitis. Together, our findings reveal a eukaryotic fungal community in the gut (the {"}mycobiome{"}) that coexists with bacteria and substantially expands the repertoire of organisms interacting with the intestinal immune system to influence health and disease.",
author = "Iliev, {Iliyan D} and Funari, {Vincent A} and Taylor, {Kent D} and Quoclinh Nguyen and Reyes, {Christopher N} and Strom, {Samuel P} and Jordan Brown and Becker, {Courtney A} and Fleshner, {Phillip R} and Marla Dubinsky and Rotter, {Jerome I} and Wang, {Hanlin L} and McGovern, {Dermot P B} and Brown, {Gordon D} and Underhill, {David M}",
year = "2012",
month = "6",
day = "8",
doi = "10.1126/science.1221789",
language = "English",
volume = "336",
pages = "1314--1317",
journal = "Science",
issn = "0036-8075",
publisher = "AMER ASSOC ADVANCEMENT SCIENCE",
number = "6086",

}

TY - JOUR

T1 - Interactions between commensal fungi and the C-type lectin receptor Dectin-1 influence colitis

AU - Iliev, Iliyan D

AU - Funari, Vincent A

AU - Taylor, Kent D

AU - Nguyen, Quoclinh

AU - Reyes, Christopher N

AU - Strom, Samuel P

AU - Brown, Jordan

AU - Becker, Courtney A

AU - Fleshner, Phillip R

AU - Dubinsky, Marla

AU - Rotter, Jerome I

AU - Wang, Hanlin L

AU - McGovern, Dermot P B

AU - Brown, Gordon D

AU - Underhill, David M

PY - 2012/6/8

Y1 - 2012/6/8

N2 - The intestinal microflora, typically equated with bacteria, influences diseases such as obesity and inflammatory bowel disease. Here, we show that the mammalian gut contains a rich fungal community that interacts with the immune system through the innate immune receptor Dectin-1. Mice lacking Dectin-1 exhibited increased susceptibility to chemically induced colitis, which was the result of altered responses to indigenous fungi. In humans, we identified a polymorphism in the gene for Dectin-1 (CLEC7A) that is strongly linked to a severe form of ulcerative colitis. Together, our findings reveal a eukaryotic fungal community in the gut (the "mycobiome") that coexists with bacteria and substantially expands the repertoire of organisms interacting with the intestinal immune system to influence health and disease.

AB - The intestinal microflora, typically equated with bacteria, influences diseases such as obesity and inflammatory bowel disease. Here, we show that the mammalian gut contains a rich fungal community that interacts with the immune system through the innate immune receptor Dectin-1. Mice lacking Dectin-1 exhibited increased susceptibility to chemically induced colitis, which was the result of altered responses to indigenous fungi. In humans, we identified a polymorphism in the gene for Dectin-1 (CLEC7A) that is strongly linked to a severe form of ulcerative colitis. Together, our findings reveal a eukaryotic fungal community in the gut (the "mycobiome") that coexists with bacteria and substantially expands the repertoire of organisms interacting with the intestinal immune system to influence health and disease.

U2 - 10.1126/science.1221789

DO - 10.1126/science.1221789

M3 - Article

VL - 336

SP - 1314

EP - 1317

JO - Science

JF - Science

SN - 0036-8075

IS - 6086

ER -