Interactions of fungal pathogens with phagocytes

Lars P Erwig, Neil A R Gow

Research output: Contribution to journalLiterature review

207 Citations (Scopus)

Abstract

The surveillance and elimination of fungal pathogens rely heavily on the sentinel behaviour of phagocytic cells of the innate immune system, especially macrophages and neutrophils. The efficiency by which these cells recognize, uptake and kill fungal pathogens depends on the size, shape and composition of the fungal cells and the success or failure of various fungal mechanisms of immune evasion. In this Review, we describe how fungi, particularly Candida albicans, interact with phagocytic cells and discuss the many factors that contribute to fungal immune evasion and prevent host elimination of these pathogenic microorganisms.

Original languageEnglish
Pages (from-to)163-176
Number of pages14
JournalNature Reviews Microbiology
Volume14
Issue number3
Early online date8 Feb 2016
DOIs
Publication statusPublished - Mar 2016

Keywords

  • Fungal host response
  • Fungal immune evasion
  • Fungal infection
  • Fungal pathogenesis

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