Interactions of fungal pathogens with phagocytes

Lars P Erwig, Neil A R Gow

Research output: Contribution to journalLiterature review

168 Citations (Scopus)

Abstract

The surveillance and elimination of fungal pathogens rely heavily on the sentinel behaviour of phagocytic cells of the innate immune system, especially macrophages and neutrophils. The efficiency by which these cells recognize, uptake and kill fungal pathogens depends on the size, shape and composition of the fungal cells and the success or failure of various fungal mechanisms of immune evasion. In this Review, we describe how fungi, particularly Candida albicans, interact with phagocytic cells and discuss the many factors that contribute to fungal immune evasion and prevent host elimination of these pathogenic microorganisms.

Original languageEnglish
Pages (from-to)163-176
Number of pages14
JournalNature Reviews Microbiology
Volume14
Issue number3
Early online date8 Feb 2016
DOIs
Publication statusPublished - Mar 2016

Fingerprint

Immune Evasion
Phagocytes
Candida albicans
Immune System
Neutrophils
Fungi
Macrophages
cyhalothrin

Keywords

  • Fungal host response
  • Fungal immune evasion
  • Fungal infection
  • Fungal pathogenesis

Cite this

Interactions of fungal pathogens with phagocytes. / Erwig, Lars P; Gow, Neil A R.

In: Nature Reviews Microbiology, Vol. 14, No. 3, 03.2016, p. 163-176.

Research output: Contribution to journalLiterature review

@article{784ee13f2ed74423ba01b1c105f54e6e,
title = "Interactions of fungal pathogens with phagocytes",
abstract = "The surveillance and elimination of fungal pathogens rely heavily on the sentinel behaviour of phagocytic cells of the innate immune system, especially macrophages and neutrophils. The efficiency by which these cells recognize, uptake and kill fungal pathogens depends on the size, shape and composition of the fungal cells and the success or failure of various fungal mechanisms of immune evasion. In this Review, we describe how fungi, particularly Candida albicans, interact with phagocytic cells and discuss the many factors that contribute to fungal immune evasion and prevent host elimination of these pathogenic microorganisms.",
keywords = "Fungal host response , Fungal immune evasion, Fungal infection , Fungal pathogenesis",
author = "Erwig, {Lars P} and Gow, {Neil A R}",
note = "The authors acknowledge L. Wight and the microscopy facility at the University of Aberdeen. The authors also acknowledge the support of the Wellcome Trust (grants 080088. 075470 and 099215) and a Wellcome Trust Strategic Award for Medical Mycology and Fungal Immunology (grant 097377).",
year = "2016",
month = "3",
doi = "10.1038/nrmicro.2015.21",
language = "English",
volume = "14",
pages = "163--176",
journal = "Nature Reviews Microbiology",
issn = "1740-1526",
publisher = "Nature Publishing Group",
number = "3",

}

TY - JOUR

T1 - Interactions of fungal pathogens with phagocytes

AU - Erwig, Lars P

AU - Gow, Neil A R

N1 - The authors acknowledge L. Wight and the microscopy facility at the University of Aberdeen. The authors also acknowledge the support of the Wellcome Trust (grants 080088. 075470 and 099215) and a Wellcome Trust Strategic Award for Medical Mycology and Fungal Immunology (grant 097377).

PY - 2016/3

Y1 - 2016/3

N2 - The surveillance and elimination of fungal pathogens rely heavily on the sentinel behaviour of phagocytic cells of the innate immune system, especially macrophages and neutrophils. The efficiency by which these cells recognize, uptake and kill fungal pathogens depends on the size, shape and composition of the fungal cells and the success or failure of various fungal mechanisms of immune evasion. In this Review, we describe how fungi, particularly Candida albicans, interact with phagocytic cells and discuss the many factors that contribute to fungal immune evasion and prevent host elimination of these pathogenic microorganisms.

AB - The surveillance and elimination of fungal pathogens rely heavily on the sentinel behaviour of phagocytic cells of the innate immune system, especially macrophages and neutrophils. The efficiency by which these cells recognize, uptake and kill fungal pathogens depends on the size, shape and composition of the fungal cells and the success or failure of various fungal mechanisms of immune evasion. In this Review, we describe how fungi, particularly Candida albicans, interact with phagocytic cells and discuss the many factors that contribute to fungal immune evasion and prevent host elimination of these pathogenic microorganisms.

KW - Fungal host response

KW - Fungal immune evasion

KW - Fungal infection

KW - Fungal pathogenesis

U2 - 10.1038/nrmicro.2015.21

DO - 10.1038/nrmicro.2015.21

M3 - Literature review

C2 - 26853116

VL - 14

SP - 163

EP - 176

JO - Nature Reviews Microbiology

JF - Nature Reviews Microbiology

SN - 1740-1526

IS - 3

ER -