Interleukin 18 receptor 1 gene polymorphisms are associated with asthma

G. Zhu, M. Whyte, J. Vestbo, K. H. Carlsen, W. Lenney, M. Silverman, Peter Joseph Benedict Helms, S. G. Pillai

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Endothelin-1 (EDN1) has been reported to be implicated in the pathophysiology of asthma. Literature results on the genetic association of EDN1 in asthma are inconsistent. Eleven single nucleotide polymorphisms in EDN1 were genotyped in 342 and 100 families from UK and Norway, respectively. Asthma, bronchial hyperreactivity (BHR) and atopic asthma phenotypes were analyzed for the family-based association. Five single nucleotide polymorphisms (SNPs) were associated with asthma (0.0017 <= P <= 0.0291), five with BHR (0.0026 <= P <= 0.0315) and three with atopic asthma (0.0016 <= P <= 0.041) in the UK population. Three SNPs were associated with asthma (0.0041 <= P <= 0.019), seven with BHR (0.0018 <= P <= 0.041) and two with atopic asthma (0.0123 <= P <= 0.0153) in the Norwegian population. A polymorphism (rs1800541) in the promoter region of EDN1 was replicated in the two populations. A nonsynonymous coding polymorphism (rs5370) resulting in a change of amino acid Asn to Lys at position 198 was also replicated. The results of haplotype-based association analyses strongly supported the ones of single SNP associations. This study demonstrates the significant evidence of association between polymorphisms in EDN1 and asthma.

Original languageEnglish
Pages (from-to)1083-1090
Number of pages8
JournalEJHG : European journal of human genetics : the official journal of the European Society of Human Genetics.
Volume16
Issue number9
Early online date2 Apr 2008
DOIs
Publication statusPublished - Sep 2008

Keywords

  • asthma
  • EDN1
  • genetic association
  • haplotype analysis
  • replication
  • genome-wide search
  • Bronchoalveolar Lavage Fluid
  • chromosomal assignment
  • susceptibility loci
  • founder population
  • gene polymorphisms
  • atopic diseases
  • candidate genes
  • receptor
  • family

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