Interleukin 1ß polymorphisms increase risk of hypochlorhydria and atrophic gastritis and reduce risk of duodenal ulcer recurrence in Japan

T. Furuta, Emad Munir El-Omar, F. Xiao, N. Shirai, M. Takashima, H. Sugimura

Research output: Contribution to journalArticle

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Abstract

Background & Aims: Interieukin-1 beta (IL-1beta) polymorphisms are associated with increased risk of gastric cancer in whites. This study aimed to examine effects of these polymorphisms on gastric acid secretion, atrophic gastritis, and risk of peptic ulcer in Japan. Methods: We determined IL-1B-511/-31 and IL-1RN genotypes and measured gastric juice pH, serum pepsinogen (PG) I and 11 levels, and gastritis and atrophy scores in Helicobacter pylori-positive patients with gastritis only, gastric ulcers, or duodenal ulcers (DUs), and H. pylori-negative controls. Results: In the H. pylori-positive group, subjects with the proinflammatory IL-lB-511 T/T genotype had the highest atrophy and gastritis scores, the highest median gastric juice pH, and the lowest median serum PG 1/PG 11 ratios. Although gastric juice pH significantly increased and serum PG I and PG 1/PG 11 ratios significantly decreased in the IL-1B-511 T/T genotype group with age, no such age-dependent changes were observed in the C/C genotype group. Changes in the C/T genotype group were intermediate. In the H. pylori-negative group, the IL-1 loci had no effect on any of the physiologic or morphologic parameters. Carriage of IL-1RN allele 2 significantly protected against DU disease while the IL-1B-511 T/T genotype significantly protected against DU recurrence in patients older than 60 years. Conclusions: Proinflammatory IL-1beta polymorphisms are associated with hypochlorhydria and atrophic gastritis in Japan. The effects are dependent on H. pylori infection and become more significant with advancing age. This may explain the high incidence of gastric cancer in Japan and also the age-dependent decrease in DU recurrence in infected subjects.

Original languageEnglish
Pages (from-to)92-105
Number of pages13
JournalGastroenterology
Volume123
Issue number1
DOIs
Publication statusPublished - Jul 2002

Keywords

  • HELICOBACTER-PYLORI INFECTION
  • ACID-SECRETION
  • JUICE PH
  • CANCER
  • PEPSINOGENS
  • DISEASE
  • ERADICATION
  • INDUCTION
  • ALPHA

Cite this

Interleukin 1ß polymorphisms increase risk of hypochlorhydria and atrophic gastritis and reduce risk of duodenal ulcer recurrence in Japan. / Furuta, T.; El-Omar, Emad Munir; Xiao, F.; Shirai, N.; Takashima, M.; Sugimura, H.

In: Gastroenterology, Vol. 123, No. 1, 07.2002, p. 92-105.

Research output: Contribution to journalArticle

Furuta, T. ; El-Omar, Emad Munir ; Xiao, F. ; Shirai, N. ; Takashima, M. ; Sugimura, H. / Interleukin 1ß polymorphisms increase risk of hypochlorhydria and atrophic gastritis and reduce risk of duodenal ulcer recurrence in Japan. In: Gastroenterology. 2002 ; Vol. 123, No. 1. pp. 92-105.
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abstract = "Background & Aims: Interieukin-1 beta (IL-1beta) polymorphisms are associated with increased risk of gastric cancer in whites. This study aimed to examine effects of these polymorphisms on gastric acid secretion, atrophic gastritis, and risk of peptic ulcer in Japan. Methods: We determined IL-1B-511/-31 and IL-1RN genotypes and measured gastric juice pH, serum pepsinogen (PG) I and 11 levels, and gastritis and atrophy scores in Helicobacter pylori-positive patients with gastritis only, gastric ulcers, or duodenal ulcers (DUs), and H. pylori-negative controls. Results: In the H. pylori-positive group, subjects with the proinflammatory IL-lB-511 T/T genotype had the highest atrophy and gastritis scores, the highest median gastric juice pH, and the lowest median serum PG 1/PG 11 ratios. Although gastric juice pH significantly increased and serum PG I and PG 1/PG 11 ratios significantly decreased in the IL-1B-511 T/T genotype group with age, no such age-dependent changes were observed in the C/C genotype group. Changes in the C/T genotype group were intermediate. In the H. pylori-negative group, the IL-1 loci had no effect on any of the physiologic or morphologic parameters. Carriage of IL-1RN allele 2 significantly protected against DU disease while the IL-1B-511 T/T genotype significantly protected against DU recurrence in patients older than 60 years. Conclusions: Proinflammatory IL-1beta polymorphisms are associated with hypochlorhydria and atrophic gastritis in Japan. The effects are dependent on H. pylori infection and become more significant with advancing age. This may explain the high incidence of gastric cancer in Japan and also the age-dependent decrease in DU recurrence in infected subjects.",
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author = "T. Furuta and El-Omar, {Emad Munir} and F. Xiao and N. Shirai and M. Takashima and H. Sugimura",
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T1 - Interleukin 1ß polymorphisms increase risk of hypochlorhydria and atrophic gastritis and reduce risk of duodenal ulcer recurrence in Japan

AU - Furuta, T.

AU - El-Omar, Emad Munir

AU - Xiao, F.

AU - Shirai, N.

AU - Takashima, M.

AU - Sugimura, H.

PY - 2002/7

Y1 - 2002/7

N2 - Background & Aims: Interieukin-1 beta (IL-1beta) polymorphisms are associated with increased risk of gastric cancer in whites. This study aimed to examine effects of these polymorphisms on gastric acid secretion, atrophic gastritis, and risk of peptic ulcer in Japan. Methods: We determined IL-1B-511/-31 and IL-1RN genotypes and measured gastric juice pH, serum pepsinogen (PG) I and 11 levels, and gastritis and atrophy scores in Helicobacter pylori-positive patients with gastritis only, gastric ulcers, or duodenal ulcers (DUs), and H. pylori-negative controls. Results: In the H. pylori-positive group, subjects with the proinflammatory IL-lB-511 T/T genotype had the highest atrophy and gastritis scores, the highest median gastric juice pH, and the lowest median serum PG 1/PG 11 ratios. Although gastric juice pH significantly increased and serum PG I and PG 1/PG 11 ratios significantly decreased in the IL-1B-511 T/T genotype group with age, no such age-dependent changes were observed in the C/C genotype group. Changes in the C/T genotype group were intermediate. In the H. pylori-negative group, the IL-1 loci had no effect on any of the physiologic or morphologic parameters. Carriage of IL-1RN allele 2 significantly protected against DU disease while the IL-1B-511 T/T genotype significantly protected against DU recurrence in patients older than 60 years. Conclusions: Proinflammatory IL-1beta polymorphisms are associated with hypochlorhydria and atrophic gastritis in Japan. The effects are dependent on H. pylori infection and become more significant with advancing age. This may explain the high incidence of gastric cancer in Japan and also the age-dependent decrease in DU recurrence in infected subjects.

AB - Background & Aims: Interieukin-1 beta (IL-1beta) polymorphisms are associated with increased risk of gastric cancer in whites. This study aimed to examine effects of these polymorphisms on gastric acid secretion, atrophic gastritis, and risk of peptic ulcer in Japan. Methods: We determined IL-1B-511/-31 and IL-1RN genotypes and measured gastric juice pH, serum pepsinogen (PG) I and 11 levels, and gastritis and atrophy scores in Helicobacter pylori-positive patients with gastritis only, gastric ulcers, or duodenal ulcers (DUs), and H. pylori-negative controls. Results: In the H. pylori-positive group, subjects with the proinflammatory IL-lB-511 T/T genotype had the highest atrophy and gastritis scores, the highest median gastric juice pH, and the lowest median serum PG 1/PG 11 ratios. Although gastric juice pH significantly increased and serum PG I and PG 1/PG 11 ratios significantly decreased in the IL-1B-511 T/T genotype group with age, no such age-dependent changes were observed in the C/C genotype group. Changes in the C/T genotype group were intermediate. In the H. pylori-negative group, the IL-1 loci had no effect on any of the physiologic or morphologic parameters. Carriage of IL-1RN allele 2 significantly protected against DU disease while the IL-1B-511 T/T genotype significantly protected against DU recurrence in patients older than 60 years. Conclusions: Proinflammatory IL-1beta polymorphisms are associated with hypochlorhydria and atrophic gastritis in Japan. The effects are dependent on H. pylori infection and become more significant with advancing age. This may explain the high incidence of gastric cancer in Japan and also the age-dependent decrease in DU recurrence in infected subjects.

KW - HELICOBACTER-PYLORI INFECTION

KW - ACID-SECRETION

KW - JUICE PH

KW - CANCER

KW - PEPSINOGENS

KW - DISEASE

KW - ERADICATION

KW - INDUCTION

KW - ALPHA

U2 - 10.1053/gast.2002.34156

DO - 10.1053/gast.2002.34156

M3 - Article

VL - 123

SP - 92

EP - 105

JO - Gastroenterology

JF - Gastroenterology

SN - 0016-5085

IS - 1

ER -