Intermediate and Long-Term Outcomes of Survivors of Acute Kidney Injury Episodes: A Large Population-Based Cohort Study

Simon Sawhney; Angharad Marks; Nick Fluck; Adeera Levin; Gordon Prescott; Corri Black

doi:10.1053/j.ajkd.2016.05.018

Intermediate and Long-Term Outcomes of Survivors of Acute Kidney Injury Episodes: A Large Population-Based Cohort Study

Simon Sawhney, Angharad Marks, Nick Fluck, Adeera Levin, Gordon Prescott, Corri Black

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Abstract

Background The long-term prognosis after acute kidney injury (AKI) is variable. It is unclear how the prognosis of AKI and its relationship to prognostic factors (baseline kidney function, AKI severity, prior AKI episodes, and recovery of kidney function) change as follow-up progresses. Study Design Observational cohort study. Setting & Participants The Grampian Laboratory Outcomes Morbidity and Mortality Study II (GLOMMS-II) is a large regional population cohort with complete serial biochemistry and outcome data capture through data linkage. From GLOMMS-II, we followed up 17,630 patients hospitalized in 2003 through to 2013.

Original language	English
Pages (from-to)	18-28
Number of pages	11
Journal	American Journal of Kidney Diseases
Volume	69
Issue number	1
Early online date	21 Aug 2016
DOIs	https://doi.org/10.1053/j.ajkd.2016.05.018
Publication status	Published - 1 Jan 2017

Keywords

Acute kidney injury (AKI)
chronic kidney disease (CKD)
baseline kidney function
survival
mortality
epidemiology
outcomes
prognosis
AKI recovery
acute on chronic kidney disease

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10.1053/j.ajkd.2016.05.018Licence: CC BY

Intermediate and Long-term Outcomes of Survivors of Acute Kidney Injury Episodes
Under a Creative Commons license https://creativecommons.org/licenses/by/4.0/
Final published version, 1.1 MBLicence: CC BY

Corri Black
Person: Clinical Academic
Simon Sawhney
Person: Clinical Academic

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title = "Intermediate and Long-Term Outcomes of Survivors of Acute Kidney Injury Episodes: A Large Population-Based Cohort Study",

abstract = "Background The long-term prognosis after acute kidney injury (AKI) is variable. It is unclear how the prognosis of AKI and its relationship to prognostic factors (baseline kidney function, AKI severity, prior AKI episodes, and recovery of kidney function) change as follow-up progresses. Study Design Observational cohort study. Setting & Participants The Grampian Laboratory Outcomes Morbidity and Mortality Study II (GLOMMS-II) is a large regional population cohort with complete serial biochemistry and outcome data capture through data linkage. From GLOMMS-II, we followed up 17,630 patients hospitalized in 2003 through to 2013.",

keywords = "Acute kidney injury (AKI), chronic kidney disease (CKD), baseline kidney function, survival, mortality, epidemiology, outcomes, prognosis, AKI recovery, acute on chronic kidney disease",

author = "Simon Sawhney and Angharad Marks and Nick Fluck and Adeera Levin and Gordon Prescott and Corri Black",

note = "Acknowledgements Support: We acknowledge the data management support of Grampian Data Safe Haven and the associated financial support of NHS Research Scotland, through NHS Grampian investment in the Grampian Data Safe Haven. Dr Sawhney is supported by a Clinical Research Training Fellowship from the Wellcome Trust (reference no. 102729/Z/13/Z). We also acknowledge support from The Farr Institute of Health Informatics Research, which is supported by a 10-funder consortium: Arthritis Research UK, the British Heart Foundation, Cancer Research UK, the Economic and Social Research Council, the Engineering and Physical Sciences Research Council, the Medical Research Council, the National Institute of Health Research, the National Institute for Social Care and Health Research (Welsh Assembly Government), the Chief Scientist Office (Scottish Government Health Directorates), and the Wellcome Trust (Medical Research Council grant no: Scotland MR/K007017/1). The funders of this study had no role in study design; collection, analysis, and interpretation of data; writing the report; and the decision to submit the report for publication.",

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T1 - Intermediate and Long-Term Outcomes of Survivors of Acute Kidney Injury Episodes

T2 - A Large Population-Based Cohort Study

AU - Sawhney, Simon

AU - Marks, Angharad

AU - Fluck, Nick

AU - Levin, Adeera

AU - Prescott, Gordon

AU - Black, Corri

N1 - Acknowledgements Support: We acknowledge the data management support of Grampian Data Safe Haven and the associated financial support of NHS Research Scotland, through NHS Grampian investment in the Grampian Data Safe Haven. Dr Sawhney is supported by a Clinical Research Training Fellowship from the Wellcome Trust (reference no. 102729/Z/13/Z). We also acknowledge support from The Farr Institute of Health Informatics Research, which is supported by a 10-funder consortium: Arthritis Research UK, the British Heart Foundation, Cancer Research UK, the Economic and Social Research Council, the Engineering and Physical Sciences Research Council, the Medical Research Council, the National Institute of Health Research, the National Institute for Social Care and Health Research (Welsh Assembly Government), the Chief Scientist Office (Scottish Government Health Directorates), and the Wellcome Trust (Medical Research Council grant no: Scotland MR/K007017/1). The funders of this study had no role in study design; collection, analysis, and interpretation of data; writing the report; and the decision to submit the report for publication.

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Background The long-term prognosis after acute kidney injury (AKI) is variable. It is unclear how the prognosis of AKI and its relationship to prognostic factors (baseline kidney function, AKI severity, prior AKI episodes, and recovery of kidney function) change as follow-up progresses. Study Design Observational cohort study. Setting & Participants The Grampian Laboratory Outcomes Morbidity and Mortality Study II (GLOMMS-II) is a large regional population cohort with complete serial biochemistry and outcome data capture through data linkage. From GLOMMS-II, we followed up 17,630 patients hospitalized in 2003 through to 2013.

AB - Background The long-term prognosis after acute kidney injury (AKI) is variable. It is unclear how the prognosis of AKI and its relationship to prognostic factors (baseline kidney function, AKI severity, prior AKI episodes, and recovery of kidney function) change as follow-up progresses. Study Design Observational cohort study. Setting & Participants The Grampian Laboratory Outcomes Morbidity and Mortality Study II (GLOMMS-II) is a large regional population cohort with complete serial biochemistry and outcome data capture through data linkage. From GLOMMS-II, we followed up 17,630 patients hospitalized in 2003 through to 2013.

KW - Acute kidney injury (AKI)

KW - chronic kidney disease (CKD)

KW - baseline kidney function

KW - survival

KW - mortality

KW - epidemiology

KW - outcomes

KW - prognosis

KW - AKI recovery

KW - acute on chronic kidney disease

U2 - 10.1053/j.ajkd.2016.05.018

DO - 10.1053/j.ajkd.2016.05.018

M3 - Article

VL - 69

SP - 18

EP - 28

JO - American Journal of Kidney Diseases

JF - American Journal of Kidney Diseases

SN - 0272-6386

IS - 1

ER -

Intermediate and Long-Term Outcomes of Survivors of Acute Kidney Injury Episodes: A Large Population-Based Cohort Study

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Simon Sawhney

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