Intermediate and Long-Term Outcomes of Survivors of Acute Kidney Injury Episodes: A Large Population-Based Cohort Study

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Abstract

Background The long-term prognosis after acute kidney injury (AKI) is variable. It is unclear how the prognosis of AKI and its relationship to prognostic factors (baseline kidney function, AKI severity, prior AKI episodes, and recovery of kidney function) change as follow-up progresses. Study Design Observational cohort study. Setting & Participants The Grampian Laboratory Outcomes Morbidity and Mortality Study II (GLOMMS-II) is a large regional population cohort with complete serial biochemistry and outcome data capture through data linkage. From GLOMMS-II, we followed up 17,630 patients hospitalized in 2003 through to 2013.
Original languageEnglish
Pages (from-to)18-28
Number of pages11
JournalAmerican Journal of Kidney Diseases
Volume69
Issue number1
Early online date21 Aug 2016
DOIs
Publication statusPublished - 1 Jan 2017

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Acute Kidney Injury
Survivors
Cohort Studies
Population
Morbidity
Kidney
Mortality
Information Storage and Retrieval
Recovery of Function
Biochemistry

Keywords

  • Acute kidney injury (AKI)
  • chronic kidney disease (CKD)
  • baseline kidney function
  • survival
  • mortality
  • epidemiology
  • outcomes
  • prognosis
  • AKI recovery
  • acute on chronic kidney disease

Cite this

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title = "Intermediate and Long-Term Outcomes of Survivors of Acute Kidney Injury Episodes: A Large Population-Based Cohort Study",
abstract = "Background The long-term prognosis after acute kidney injury (AKI) is variable. It is unclear how the prognosis of AKI and its relationship to prognostic factors (baseline kidney function, AKI severity, prior AKI episodes, and recovery of kidney function) change as follow-up progresses. Study Design Observational cohort study. Setting & Participants The Grampian Laboratory Outcomes Morbidity and Mortality Study II (GLOMMS-II) is a large regional population cohort with complete serial biochemistry and outcome data capture through data linkage. From GLOMMS-II, we followed up 17,630 patients hospitalized in 2003 through to 2013.",
keywords = "Acute kidney injury (AKI), chronic kidney disease (CKD), baseline kidney function, survival, mortality, epidemiology, outcomes, prognosis, AKI recovery, acute on chronic kidney disease",
author = "Simon Sawhney and Angharad Marks and Nick Fluck and Adeera Levin and Gordon Prescott and Corri Black",
note = "Acknowledgements Support: We acknowledge the data management support of Grampian Data Safe Haven and the associated financial support of NHS Research Scotland, through NHS Grampian investment in the Grampian Data Safe Haven. Dr Sawhney is supported by a Clinical Research Training Fellowship from the Wellcome Trust (reference no. 102729/Z/13/Z). We also acknowledge support from The Farr Institute of Health Informatics Research, which is supported by a 10-funder consortium: Arthritis Research UK, the British Heart Foundation, Cancer Research UK, the Economic and Social Research Council, the Engineering and Physical Sciences Research Council, the Medical Research Council, the National Institute of Health Research, the National Institute for Social Care and Health Research (Welsh Assembly Government), the Chief Scientist Office (Scottish Government Health Directorates), and the Wellcome Trust (Medical Research Council grant no: Scotland MR/K007017/1). The funders of this study had no role in study design; collection, analysis, and interpretation of data; writing the report; and the decision to submit the report for publication.",
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doi = "10.1053/j.ajkd.2016.05.018",
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journal = "American Journal of Kidney Diseases",
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T1 - Intermediate and Long-Term Outcomes of Survivors of Acute Kidney Injury Episodes

T2 - A Large Population-Based Cohort Study

AU - Sawhney, Simon

AU - Marks, Angharad

AU - Fluck, Nick

AU - Levin, Adeera

AU - Prescott, Gordon

AU - Black, Corri

N1 - Acknowledgements Support: We acknowledge the data management support of Grampian Data Safe Haven and the associated financial support of NHS Research Scotland, through NHS Grampian investment in the Grampian Data Safe Haven. Dr Sawhney is supported by a Clinical Research Training Fellowship from the Wellcome Trust (reference no. 102729/Z/13/Z). We also acknowledge support from The Farr Institute of Health Informatics Research, which is supported by a 10-funder consortium: Arthritis Research UK, the British Heart Foundation, Cancer Research UK, the Economic and Social Research Council, the Engineering and Physical Sciences Research Council, the Medical Research Council, the National Institute of Health Research, the National Institute for Social Care and Health Research (Welsh Assembly Government), the Chief Scientist Office (Scottish Government Health Directorates), and the Wellcome Trust (Medical Research Council grant no: Scotland MR/K007017/1). The funders of this study had no role in study design; collection, analysis, and interpretation of data; writing the report; and the decision to submit the report for publication.

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Y1 - 2017/1/1

N2 - Background The long-term prognosis after acute kidney injury (AKI) is variable. It is unclear how the prognosis of AKI and its relationship to prognostic factors (baseline kidney function, AKI severity, prior AKI episodes, and recovery of kidney function) change as follow-up progresses. Study Design Observational cohort study. Setting & Participants The Grampian Laboratory Outcomes Morbidity and Mortality Study II (GLOMMS-II) is a large regional population cohort with complete serial biochemistry and outcome data capture through data linkage. From GLOMMS-II, we followed up 17,630 patients hospitalized in 2003 through to 2013.

AB - Background The long-term prognosis after acute kidney injury (AKI) is variable. It is unclear how the prognosis of AKI and its relationship to prognostic factors (baseline kidney function, AKI severity, prior AKI episodes, and recovery of kidney function) change as follow-up progresses. Study Design Observational cohort study. Setting & Participants The Grampian Laboratory Outcomes Morbidity and Mortality Study II (GLOMMS-II) is a large regional population cohort with complete serial biochemistry and outcome data capture through data linkage. From GLOMMS-II, we followed up 17,630 patients hospitalized in 2003 through to 2013.

KW - Acute kidney injury (AKI)

KW - chronic kidney disease (CKD)

KW - baseline kidney function

KW - survival

KW - mortality

KW - epidemiology

KW - outcomes

KW - prognosis

KW - AKI recovery

KW - acute on chronic kidney disease

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DO - 10.1053/j.ajkd.2016.05.018

M3 - Article

VL - 69

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JO - American Journal of Kidney Diseases

JF - American Journal of Kidney Diseases

SN - 0272-6386

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ER -