International validation of the EORTC QLQ-ELD14 questionnaire for assessment of health-related quality of life elderly patients with cancer

Sally J Wheelwright (Corresponding Author), A.S. Darlington, D Fitzsimmons, Peter Fayers, J. I. Arraras, F Bonnetain, E Brain, A Bredart, W-C Chie, J Giesinger, E Hammerlid, S.J. O'Connor, S Oerlemans, A Pallis, M Reed, N. Singhal, V Vsasilou, T Young, C Johnson, EORTC Quality of Life Group

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Abstract

Background: Older people represent the majority of cancer patients but their specific needs are often ignored in the development of health-related quality of life (HRQOL) instruments. The European Organisation for Research and Treatment of Cancer (EORTC) QLQ-ELD15 was developed to supplement the EORTC’s core questionnaire, the QLQ-C30, for measuring HRQOL in patients aged >70 years in oncology studies.
Methods: Patients (n=518) from 10 countries completed the QLQ-C30, QLQ-ELD15 and a debriefing interview. Eighty two clinically stable patients repeated the questionnaires 1 week later (test–retest analysis) and 107 others, with an expected change in clinical status, repeated the questionnaires 3 months later (response to change analysis, RCA). 
Results: Information from the debriefing interview, factor analysis and item response theory analysis resulted in the removal of one item (QLQ-ELD15QLQ-ELD14) and revision of the proposed scale structure to five scales (mobility, worries about others, future worries, maintaining purpose and illness burden) and two single items (joint stiffness and family support). Convergent validity was good. In known-group comparisons, the QLQ-ELD14 differentiated between patients with different disease stage, treatment intention, number of comorbidities, performance status and geriatric screening scores. Test–retest and RCA analyses were equivocal.
Conclusion: The QLQ-ELD14 is a validated HRQOL questionnaire for cancer patients aged 70 years. Changes in elderly patients’ self-reported HRQOL may be related to both cancer evolution and non-clinical events.
Original languageEnglish
Pages (from-to)852-858
Number of pages7
JournalBritish Journal of Cancer
Volume109
Early online date18 Jul 2013
DOIs
Publication statusPublished - 20 Aug 2013

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Quality of Life
Organizations
Research
Neoplasms
Therapeutics
Interviews
Cost of Illness
Surveys and Questionnaires
Geriatrics
Statistical Factor Analysis
Comorbidity
Joints

Keywords

  • health-related quality of life
  • elderly
  • European Organisation for Research and Treatment of Cancer QLQ-C30
  • module validation study

Cite this

Wheelwright, S. J., Darlington, A. S., Fitzsimmons, D., Fayers, P., Arraras, J. I., Bonnetain, F., ... EORTC Quality of Life Group (2013). International validation of the EORTC QLQ-ELD14 questionnaire for assessment of health-related quality of life elderly patients with cancer. British Journal of Cancer, 109, 852-858. https://doi.org/10.1038/bjc.2013.407

International validation of the EORTC QLQ-ELD14 questionnaire for assessment of health-related quality of life elderly patients with cancer. / Wheelwright, Sally J (Corresponding Author); Darlington, A.S.; Fitzsimmons, D; Fayers, Peter; Arraras, J. I.; Bonnetain, F; Brain, E ; Bredart, A; Chie, W-C; Giesinger, J; Hammerlid, E; O'Connor, S.J.; Oerlemans, S; Pallis, A ; Reed, M; Singhal, N.; Vsasilou, V; Young, T; Johnson, C; EORTC Quality of Life Group.

In: British Journal of Cancer, Vol. 109, 20.08.2013, p. 852-858.

Research output: Contribution to journalArticle

Wheelwright, SJ, Darlington, AS, Fitzsimmons, D, Fayers, P, Arraras, JI, Bonnetain, F, Brain, E, Bredart, A, Chie, W-C, Giesinger, J, Hammerlid, E, O'Connor, SJ, Oerlemans, S, Pallis, A, Reed, M, Singhal, N, Vsasilou, V, Young, T, Johnson, C & EORTC Quality of Life Group 2013, 'International validation of the EORTC QLQ-ELD14 questionnaire for assessment of health-related quality of life elderly patients with cancer', British Journal of Cancer, vol. 109, pp. 852-858. https://doi.org/10.1038/bjc.2013.407
Wheelwright, Sally J ; Darlington, A.S. ; Fitzsimmons, D ; Fayers, Peter ; Arraras, J. I. ; Bonnetain, F ; Brain, E ; Bredart, A ; Chie, W-C ; Giesinger, J ; Hammerlid, E ; O'Connor, S.J. ; Oerlemans, S ; Pallis, A ; Reed, M ; Singhal, N. ; Vsasilou, V ; Young, T ; Johnson, C ; EORTC Quality of Life Group. / International validation of the EORTC QLQ-ELD14 questionnaire for assessment of health-related quality of life elderly patients with cancer. In: British Journal of Cancer. 2013 ; Vol. 109. pp. 852-858.
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abstract = "Background: Older people represent the majority of cancer patients but their specific needs are often ignored in the development of health-related quality of life (HRQOL) instruments. The European Organisation for Research and Treatment of Cancer (EORTC) QLQ-ELD15 was developed to supplement the EORTC’s core questionnaire, the QLQ-C30, for measuring HRQOL in patients aged >70 years in oncology studies.Methods: Patients (n=518) from 10 countries completed the QLQ-C30, QLQ-ELD15 and a debriefing interview. Eighty two clinically stable patients repeated the questionnaires 1 week later (test–retest analysis) and 107 others, with an expected change in clinical status, repeated the questionnaires 3 months later (response to change analysis, RCA). Results: Information from the debriefing interview, factor analysis and item response theory analysis resulted in the removal of one item (QLQ-ELD15QLQ-ELD14) and revision of the proposed scale structure to five scales (mobility, worries about others, future worries, maintaining purpose and illness burden) and two single items (joint stiffness and family support). Convergent validity was good. In known-group comparisons, the QLQ-ELD14 differentiated between patients with different disease stage, treatment intention, number of comorbidities, performance status and geriatric screening scores. Test–retest and RCA analyses were equivocal.Conclusion: The QLQ-ELD14 is a validated HRQOL questionnaire for cancer patients aged 70 years. Changes in elderly patients’ self-reported HRQOL may be related to both cancer evolution and non-clinical events.",
keywords = "health-related quality of life, elderly, European Organisation for Research and Treatment of Cancer QLQ-C30, module validation study",
author = "Wheelwright, {Sally J} and A.S. Darlington and D Fitzsimmons and Peter Fayers and Arraras, {J. I.} and F Bonnetain and E Brain and A Bredart and W-C Chie and J Giesinger and E Hammerlid and S.J. O'Connor and S Oerlemans and A Pallis and M Reed and N. Singhal and V Vsasilou and T Young and C Johnson and {EORTC Quality of Life Group}",
note = "ACKNOWLEDGEMENTS This study was funded by the European Organisation for Research and Treatment of Cancer Quality of Life (EORTC QOL) Group who approved the manuscript before submission. We would like to thank the reviewers from the EORTC QOL group, Mogens Gr{\o}nvold, Galina Velikova, Susanne Singer, Bernhard Holzner, Eva Greimel, Jaap Reijneveld and Andrew Bottomley. The following all contributed to participant recruitment, for which we are grateful: Dr Valerie Quipourt, Dr Genevie`ve Imbert, Dr Bernhard Holzner, Dr Annemie Courtens, Dr Jessie Wu, Ms Anne Jacob, Ms Janet Prouse, Mrs Christine Brannan and Mrs Melanie Winterbotham. We acknowledge all the centres, investigators and patients who took time to participate in the study.",
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T1 - International validation of the EORTC QLQ-ELD14 questionnaire for assessment of health-related quality of life elderly patients with cancer

AU - Wheelwright, Sally J

AU - Darlington, A.S.

AU - Fitzsimmons, D

AU - Fayers, Peter

AU - Arraras, J. I.

AU - Bonnetain, F

AU - Brain, E

AU - Bredart, A

AU - Chie, W-C

AU - Giesinger, J

AU - Hammerlid, E

AU - O'Connor, S.J.

AU - Oerlemans, S

AU - Pallis, A

AU - Reed, M

AU - Singhal, N.

AU - Vsasilou, V

AU - Young, T

AU - Johnson, C

AU - EORTC Quality of Life Group

N1 - ACKNOWLEDGEMENTS This study was funded by the European Organisation for Research and Treatment of Cancer Quality of Life (EORTC QOL) Group who approved the manuscript before submission. We would like to thank the reviewers from the EORTC QOL group, Mogens Grønvold, Galina Velikova, Susanne Singer, Bernhard Holzner, Eva Greimel, Jaap Reijneveld and Andrew Bottomley. The following all contributed to participant recruitment, for which we are grateful: Dr Valerie Quipourt, Dr Genevie`ve Imbert, Dr Bernhard Holzner, Dr Annemie Courtens, Dr Jessie Wu, Ms Anne Jacob, Ms Janet Prouse, Mrs Christine Brannan and Mrs Melanie Winterbotham. We acknowledge all the centres, investigators and patients who took time to participate in the study.

PY - 2013/8/20

Y1 - 2013/8/20

N2 - Background: Older people represent the majority of cancer patients but their specific needs are often ignored in the development of health-related quality of life (HRQOL) instruments. The European Organisation for Research and Treatment of Cancer (EORTC) QLQ-ELD15 was developed to supplement the EORTC’s core questionnaire, the QLQ-C30, for measuring HRQOL in patients aged >70 years in oncology studies.Methods: Patients (n=518) from 10 countries completed the QLQ-C30, QLQ-ELD15 and a debriefing interview. Eighty two clinically stable patients repeated the questionnaires 1 week later (test–retest analysis) and 107 others, with an expected change in clinical status, repeated the questionnaires 3 months later (response to change analysis, RCA). Results: Information from the debriefing interview, factor analysis and item response theory analysis resulted in the removal of one item (QLQ-ELD15QLQ-ELD14) and revision of the proposed scale structure to five scales (mobility, worries about others, future worries, maintaining purpose and illness burden) and two single items (joint stiffness and family support). Convergent validity was good. In known-group comparisons, the QLQ-ELD14 differentiated between patients with different disease stage, treatment intention, number of comorbidities, performance status and geriatric screening scores. Test–retest and RCA analyses were equivocal.Conclusion: The QLQ-ELD14 is a validated HRQOL questionnaire for cancer patients aged 70 years. Changes in elderly patients’ self-reported HRQOL may be related to both cancer evolution and non-clinical events.

AB - Background: Older people represent the majority of cancer patients but their specific needs are often ignored in the development of health-related quality of life (HRQOL) instruments. The European Organisation for Research and Treatment of Cancer (EORTC) QLQ-ELD15 was developed to supplement the EORTC’s core questionnaire, the QLQ-C30, for measuring HRQOL in patients aged >70 years in oncology studies.Methods: Patients (n=518) from 10 countries completed the QLQ-C30, QLQ-ELD15 and a debriefing interview. Eighty two clinically stable patients repeated the questionnaires 1 week later (test–retest analysis) and 107 others, with an expected change in clinical status, repeated the questionnaires 3 months later (response to change analysis, RCA). Results: Information from the debriefing interview, factor analysis and item response theory analysis resulted in the removal of one item (QLQ-ELD15QLQ-ELD14) and revision of the proposed scale structure to five scales (mobility, worries about others, future worries, maintaining purpose and illness burden) and two single items (joint stiffness and family support). Convergent validity was good. In known-group comparisons, the QLQ-ELD14 differentiated between patients with different disease stage, treatment intention, number of comorbidities, performance status and geriatric screening scores. Test–retest and RCA analyses were equivocal.Conclusion: The QLQ-ELD14 is a validated HRQOL questionnaire for cancer patients aged 70 years. Changes in elderly patients’ self-reported HRQOL may be related to both cancer evolution and non-clinical events.

KW - health-related quality of life

KW - elderly

KW - European Organisation for Research and Treatment of Cancer QLQ-C30

KW - module validation study

U2 - 10.1038/bjc.2013.407

DO - 10.1038/bjc.2013.407

M3 - Article

VL - 109

SP - 852

EP - 858

JO - British Journal of Cancer

JF - British Journal of Cancer

SN - 0007-0920

ER -