Aim: To assess the influence of total IgE on the association between body mass index (BMI), smoking status and blood eosinophil (B-Eos) count in healthy subjects from a large population-based sample.Methods: We analysed data on 4,785 children/adolescents (<18 years) and 5,563 adults (18-79 years) from the 2005-2006 US National Health and Nutrition Examination Survey. Subjects without any reported respiratory disease, hay fever and/or non-respiratory diseases significantly associated with B-Eos count (heart diseases, stroke, and metabolic syndrome; Amaral, R. et al. Clin Transl Allergy 2021;11:e12036), were considered healthy. Two multivariate regression models were developed with B-Eos count as outcome variable: model 1 included age, sex, race/ethnicity, BMI categories, and smoking status (in adults only); and model 2 also included total IgE.Results: A total of 3,541 healthy children/adolescents and 1,465 adults were included. In model 1, B-Eos count was significantly associated with overweight/obesity in children/adolescents and adults (p=0.041 and p=0.039, respectively) as well as with current smoking (p=0.041). In model 2, B-Eos count was significantly associated with total IgE in both age groups (p<0.001), and current smoking remained significant (p=0.020). However, BMI was no longer associated with B-Eos count (p>0.05 both groups).Conclusion: This study showed an independent relationship between B-Eos count and total IgE in healthy subjects. When adjusted for total IgE, the association between B-Eos count and BMI disappeared whereas the association with current smoking remained, indicating possible different mechanisms underlying increased B-Eos count upon these exposures.FootnotesCite this article as Eur Respir J 2022; 60: Suppl. 66, 412.This article was presented at the 2022 ERS International Congress, in session “-”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
|Journal||European Respiratory Journal|
|Issue number||Suppl. 66|
|Publication status||Published - 4 Sep 2022|
|Event||European Respiratory Society (ERS) International Congress. - FIRA Barcelona Gran Via Congress Centre, Barcelona, Spain|
Duration: 4 Sep 2022 → 6 Sep 2022