INTERRELATIONSHIPS BETWEEN SELENIUM AND THYROID-HORMONE METABOLISM IN THE RAT AND MAN

G J BECKETT, F E PETERSON, K CHOUDHURY, P W H RAE, Fergus Nicol, P S C WU, A D TOFT, A F SMITH, John Arthur

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Abstract

Labelling of rat kidney microsomes in vitro with [I-125]-bromoacetylT4 produced two bands on SDS/PAGE with Mr or 55 kDa and 27.5 kDa representing protein disulphide isomerase and type I iodothyronine deiodinase (ID-I) respectively. The amount of the 55 kDa band was unchanged by selenium (Se) deficiency but the 27.5 kDa protein was markedly decreased in kidney microsomal fraction obtained from Se-deficient rats. Concurrent Se and iodine deficiency produced a significant increase in thyroid weight, plasma thyrotrophin (TSH) and a decrease in thyroidal iodine when compared with either single Se or iodine deficiency. These results suggest that ID-I is a selenoprotein and that Se deficiency can exacerbate the hypothyroidism observed in iodine deficiency. In man, blood glutathione peroxidase and blood Se levels were decreased in hyperthyroidism due to Graves' disease whilst normal levels of these analytes were found in patients treated for Graves' disease. These results suggest that thyroid status can affect Se balance rather than Se deficiency predisposes to Graves' disease.

Original languageEnglish
Pages (from-to)265-267
Number of pages3
JournalJournal of Trace Elements & Electrolytes in Health and Disease
Volume5
Issue number4
Publication statusPublished - Dec 1991

Keywords

  • SELENIUM
  • THYROXINE
  • TRIIODOTHYRONINE
  • GLUTATHIONE PEROXIDASE

Cite this

BECKETT, G. J., PETERSON, F. E., CHOUDHURY, K., RAE, P. W. H., Nicol, F., WU, P. S. C., TOFT, A. D., SMITH, A. F., & Arthur, J. (1991). INTERRELATIONSHIPS BETWEEN SELENIUM AND THYROID-HORMONE METABOLISM IN THE RAT AND MAN. Journal of Trace Elements & Electrolytes in Health and Disease, 5(4), 265-267.