Interspecific correlation between red blood cell mitochondrial ROS production, cardiolipin content and longevity in birds

Jessica Delhaye, Nicolas Salamin, Alexandre Roulin, François Criscuolo, Pierre Bize, Philippe Christe

Research output: Contribution to journalArticle

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Abstract

Mitochondrial respiration releases reactive oxygen species (ROS) as by-products that can damage the soma and may in turn accelerate ageing. Hence, according to “the oxidative stress theory of ageing”, longer-lived organisms may have evolved mechanisms that improve mitochondrial function, reduce ROS production and/or increase cell resistance to oxidative damage. Cardiolipin, an important mitochondrial inner-membrane phospholipid, has these properties by binding and stabilizing mitochondrial inner-membrane proteins. Here, we investigated whether ROS production, cardiolipin content and cell membrane resistance to oxidative attack in freshly collected red blood cells (RBCs) are associated with longevity (range 5–35 years) in 21 bird species belonging to seven Orders. After controlling for phylogeny, body size and oxygen consumption, variation in maximum longevity was significantly explained by mitochondrial ROS production and cardiolipin content, but not by membrane resistance to oxidative attack. RBCs of longer-lived species produced less ROS and contained more cardiolipin than RBCs of shorter-lived species did. These results support the oxidative stress theory of ageing and shed light on mitochondrial cardiolipin as an important factor linking ROS production to longevity.
Original languageEnglish
Pages (from-to)433–443
Number of pages11
JournalAge
Volume38
Issue number5
Early online date29 Aug 2016
DOIs
Publication statusPublished - 1 Dec 2016

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Cardiolipins
Birds
Reactive Oxygen Species
Erythrocytes
Oxidative Stress
Mitochondrial Membranes
Body Size
Carisoprodol
Phylogeny
Oxygen Consumption
Phospholipids
Respiration
Membrane Proteins
Cell Membrane
Membranes

Keywords

  • birds
  • comparative methods
  • free radicals
  • longevity
  • phospholipids

Cite this

Interspecific correlation between red blood cell mitochondrial ROS production, cardiolipin content and longevity in birds. / Delhaye, Jessica; Salamin, Nicolas; Roulin, Alexandre; Criscuolo, François; Bize, Pierre; Christe, Philippe.

In: Age, Vol. 38, No. 5, 01.12.2016, p. 433–443.

Research output: Contribution to journalArticle

Delhaye, Jessica ; Salamin, Nicolas ; Roulin, Alexandre ; Criscuolo, François ; Bize, Pierre ; Christe, Philippe. / Interspecific correlation between red blood cell mitochondrial ROS production, cardiolipin content and longevity in birds. In: Age. 2016 ; Vol. 38, No. 5. pp. 433–443.
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