Interval breast cancer is associated with other types of tumors

Felix Grassmann*, Wei He, Mikael Eriksson, Marike Gabrielson, Per Hall, Kamila Czene

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

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Breast cancer (BC) patients diagnosed between two screenings (interval cancers) are more likely than screen-detected patients to carry rare deleterious mutations in cancer genes potentially leading to increased risk for other non-breast cancer (non-BC) tumors. In this study, we include 14,846 women diagnosed with BC of which 1,772 are interval and 13,074 screen-detected. Compared to women with screen-detected cancers, interval breast cancer patients are more likely to have a non-BC tumor before (Odds ratio (OR): 1.43 [1.19–1.70], P = 9.4 x 10−5) and after (OR: 1.28 [1.14–1.44], P = 4.70 x 10−5) breast cancer diagnosis, are more likely to report a family history of non-BC tumors and have a lower genetic risk score based on common variants for non-BC tumors. In conclusion, interval breast cancer is associated with other tumors and common cancer variants are unlikely to be responsible for this association. These findings could have implications for future screening and prevention programs.

Original languageEnglish
Article number4648
Number of pages9
JournalNature Communications
Early online date22 Oct 2019
Publication statusPublished - 22 Oct 2019


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