Intestinal colonization

how key microbial players become established in this dynamic process

Sahar El Aidy, Pieter Van den Abbeele, Tom Van de Wiele, Petra Louis, Michiel Kleerebezem

Research output: Contribution to journalLiterature review

42 Citations (Scopus)

Abstract

In this review, we provide an overview of the dynamic changes within the microbiota and its metabolites that are implicated in establishing and maintaining gastrointestinal homeostasis during various stages of microbial colonization. The gradual conversion of the gut microbiota toward a mutualistic microbial community involves replacement of pioneer gut colonizers with bacterial taxa that are characteristic for the adult gut. An important microbial signature of homeostasis in the adult gut is the prevalence and activity of a diverse spectrum of bacterial species that produce beneficial metabolites through metabolic interactions between microbial groups. Deciphering these microbial signatures and their metabolites that govern short and long-term equilibrium, as well as imbalances in host-microbial relationships, may provide novel diagnostic tools and/or therapeutic targets for specific disorders associated with intestinal dysbiosis and loss of homeostasis.
Original languageEnglish
Pages (from-to)913-923
Number of pages11
JournalBioEssays
Volume35
Issue number10
Early online date15 Aug 2013
DOIs
Publication statusPublished - Oct 2013

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Metabolites
Homeostasis
Dysbiosis
Microbial Interactions
Microbiota
Therapeutics

Keywords

  • butyrate
  • clostridium cluster IV and XIVa
  • core and microbiome
  • cross-feeding
  • fucosylation
  • mucus
  • sulfate reducing bacteria

Cite this

Intestinal colonization : how key microbial players become established in this dynamic process. / El Aidy, Sahar; Van den Abbeele, Pieter; Van de Wiele, Tom; Louis, Petra; Kleerebezem, Michiel.

In: BioEssays, Vol. 35, No. 10, 10.2013, p. 913-923.

Research output: Contribution to journalLiterature review

El Aidy, S, Van den Abbeele, P, Van de Wiele, T, Louis, P & Kleerebezem, M 2013, 'Intestinal colonization: how key microbial players become established in this dynamic process', BioEssays, vol. 35, no. 10, pp. 913-923. https://doi.org/10.1002/bies.201300073
El Aidy, Sahar ; Van den Abbeele, Pieter ; Van de Wiele, Tom ; Louis, Petra ; Kleerebezem, Michiel. / Intestinal colonization : how key microbial players become established in this dynamic process. In: BioEssays. 2013 ; Vol. 35, No. 10. pp. 913-923.
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