Intestinal Permeability and Inflammation Mediate Dietary Intake Associated Risks of Micronutrient Deficiencies at 15 Months: Results from the MAL-ED Study (OR07-04-19)

Laura E. Caulfield; Benjamin McCormick; Laura E. Murray-Kolb; Gwenyth O. Lee; Kerry J. Schulze; A. Catharine Ross; Bruna Maciel; Aldo A.M. Lima; Margaret Kosek

doi:10.1093/cdn/nzz034.OR07-04-19

Intestinal Permeability and Inflammation Mediate Dietary Intake Associated Risks of Micronutrient Deficiencies at 15 Months: Results from the MAL-ED Study (OR07-04-19)

Laura E. Caulfield, Benjamin McCormick, Laura E. Murray-Kolb, Gwenyth O. Lee, Kerry J. Schulze, A. Catharine Ross, Bruna Maciel, Aldo A.M. Lima, Margaret Kosek

The Rowett Institute of Nutrition and Health

Research output: Contribution to journal › Article › peer-review

Abstract

Objectives: We tested whether environmental enteric dysfunction (EED) is associated with risk of micronutrient deficiencies adjusting for diet and systemic inflammation, and whether it mediates the relation between intake and micronutrient status.

Methods: Data from 1283 children in the MAL-ED birth cohort were examined to evaluate risk of anemia, low plasma retinol, zinc, and ferritin, and high plasma transferrin receptor (TfR) at 15 months. We characterized gut inflammation and permeability by myeloperoxidase, neopterin, and alpha-1-antitrypsin concentrations from monthly asymptomatic fecal samples averaged from 9–15 months, and urinary recovery of lactulose (L) and mannitol (M) from LM tests at 9 and 15 months, converted to a ratio z score (LMZ) and averaged. Nutrient intakes from complementary foods were quantified monthly from 9–15 months and densities were averaged. Plasma alpha-1 acid glycoprotein at 15 months characterized systemic inflammation. Relationships among variables were modelled using a direct acyclic graph.

Original language	English
Pages (from-to)	726-726
Number of pages	1
Journal	Current developments in nutrition
Volume	3
Issue number	Suppl 1
DOIs	https://doi.org/10.1093/cdn/nzz034.OR07-04-19
Publication status	Published - 13 Jun 2019

Bibliographical note

Funding Sources: The MAL-ED study was supported by the Bill & Melinda Gates Foundation, through awards to the Foundation for the NIH and NIH/FIC.

PMCID: PMC6576140

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10.1093/cdn/nzz034.OR07-04-19

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Caulfield, L. E., McCormick, B., Murray-Kolb, L. E., Lee, G. O., Schulze, K. J., Ross, A. C., Maciel, B., Lima, A. A. M., & Kosek, M. (2019). Intestinal Permeability and Inflammation Mediate Dietary Intake Associated Risks of Micronutrient Deficiencies at 15 Months: Results from the MAL-ED Study (OR07-04-19). Current developments in nutrition, 3(Suppl 1), 726-726. https://doi.org/10.1093/cdn/nzz034.OR07-04-19

Intestinal Permeability and Inflammation Mediate Dietary Intake Associated Risks of Micronutrient Deficiencies at 15 Months: Results from the MAL-ED Study (OR07-04-19). / Caulfield, Laura E.; McCormick, Benjamin; Murray-Kolb, Laura E. et al.
In: Current developments in nutrition, Vol. 3, No. Suppl 1, 13.06.2019, p. 726-726.

Research output: Contribution to journal › Article › peer-review

Caulfield, LE, McCormick, B, Murray-Kolb, LE, Lee, GO, Schulze, KJ, Ross, AC, Maciel, B, Lima, AAM & Kosek, M 2019, 'Intestinal Permeability and Inflammation Mediate Dietary Intake Associated Risks of Micronutrient Deficiencies at 15 Months: Results from the MAL-ED Study (OR07-04-19)', Current developments in nutrition, vol. 3, no. Suppl 1, pp. 726-726. https://doi.org/10.1093/cdn/nzz034.OR07-04-19

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abstract = "Objectives: We tested whether environmental enteric dysfunction (EED) is associated with risk of micronutrient deficiencies adjusting for diet and systemic inflammation, and whether it mediates the relation between intake and micronutrient status.Methods: Data from 1283 children in the MAL-ED birth cohort were examined to evaluate risk of anemia, low plasma retinol, zinc, and ferritin, and high plasma transferrin receptor (TfR) at 15 months. We characterized gut inflammation and permeability by myeloperoxidase, neopterin, and alpha-1-antitrypsin concentrations from monthly asymptomatic fecal samples averaged from 9–15 months, and urinary recovery of lactulose (L) and mannitol (M) from LM tests at 9 and 15 months, converted to a ratio z score (LMZ) and averaged. Nutrient intakes from complementary foods were quantified monthly from 9–15 months and densities were averaged. Plasma alpha-1 acid glycoprotein at 15 months characterized systemic inflammation. Relationships among variables were modelled using a direct acyclic graph.",

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doi = "10.1093/cdn/nzz034.OR07-04-19",

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AU - McCormick, Benjamin

AU - Murray-Kolb, Laura E.

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AU - Schulze, Kerry J.

AU - Ross, A. Catharine

AU - Maciel, Bruna

AU - Lima, Aldo A.M.

AU - Kosek, Margaret

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AB - Objectives: We tested whether environmental enteric dysfunction (EED) is associated with risk of micronutrient deficiencies adjusting for diet and systemic inflammation, and whether it mediates the relation between intake and micronutrient status.Methods: Data from 1283 children in the MAL-ED birth cohort were examined to evaluate risk of anemia, low plasma retinol, zinc, and ferritin, and high plasma transferrin receptor (TfR) at 15 months. We characterized gut inflammation and permeability by myeloperoxidase, neopterin, and alpha-1-antitrypsin concentrations from monthly asymptomatic fecal samples averaged from 9–15 months, and urinary recovery of lactulose (L) and mannitol (M) from LM tests at 9 and 15 months, converted to a ratio z score (LMZ) and averaged. Nutrient intakes from complementary foods were quantified monthly from 9–15 months and densities were averaged. Plasma alpha-1 acid glycoprotein at 15 months characterized systemic inflammation. Relationships among variables were modelled using a direct acyclic graph.

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ER -

Intestinal Permeability and Inflammation Mediate Dietary Intake Associated Risks of Micronutrient Deficiencies at 15 Months: Results from the MAL-ED Study (OR07-04-19)

Abstract

Bibliographical note

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