Intrathecal cytokine responses in Trypanosoma brucei rhodesiense sleeping sickness patients

Lorna Mairi MacLean, M. Odiit, Jeremy M Sternberg

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35 Citations (Scopus)

Abstract

Intrathecal cytokine levels and blood -cerebrospinal fluid (CSF) barrier function were studied in 91 Trypanosoma brucei rhodesiense-infected patients. The CSF concentration of the cellular immune activation marker neopterin and the cytokines IL-6 and IL-10 were increased over control and post-treatment levels in all patients, with maximal levels observed in late-stage (meningoencephalitic) individuals. Analysis of CSF/serum concentration quotients indicated that IL-10 and neopterin were derived from central nervous system synthesis in at least 25% of the patients. Blood-CSF barrier dysfunction occurred in 64% of late-stage patients but not in early-stage patients. While the high level of neopterin observed in the late-stage patient CSF is indicative of widespread cellular activation, the increased levels of IL-6 and IL-10 suggest that counter-inflammatory cellular responses may be important in the regulation of neuropathogenesis in late-stage human African trypanosomiasis. (c) 2005 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)270-275
Number of pages5
JournalTransactions of the Royal Society of Tropical Medicine and Hygiene
Volume100
Issue number3
DOIs
Publication statusPublished - Mar 2006

Keywords

  • trypanosomiasis
  • Trypanosoma brucei rhodesiense
  • cerebrospinat fluid
  • neuropathogenesis
  • neopterin
  • cytokine
  • Uganda
  • CENTRAL-NERVOUS-SYSTEM
  • HUMAN AFRICAN TRYPANOSOMIASIS
  • NECROSIS-FACTOR-ALPHA
  • CEREBROSPINAL-FLUID
  • NITRIC-OXIDE
  • NEOPTERIN
  • SERUM
  • INTERLEUKIN-6
  • INVOLVEMENT
  • DIAGNOSIS

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