Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 1255-1262 |
| Number of pages | 8 |
| Journal | European Heart Journal |
| Volume | 35 |
| Issue number | 19 |
| Early online date | 17 Mar 2014 |
| DOIs | |
| Publication status | Published - May 2014 |
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Keywords
- acute myocardial infarction
- ischaemia-reperfusion injury
- cardioprotection
- nitrite
Cite this
Intravenous sodium nitrite in acute ST-elevation myocardial infarction : a randomized controlled trial (NIAMI). / Siddiqi, Nishat; Neil, Christopher; Bruce, Margaret; Maclennan, Graeme; Cotton, Seonaidh Claire; Papadopoulou, Sofia; Feelisch, Martin; Bunce, Nicholas; Lim, Pitt O; Hildick-Smith, David; Horowitz, John; Madhani, Melanie; Boon, Nicholas; Dawson, Dana; Kaski, Juan Carlos; Frenneaux, Michael; NIAMI investigators.
In: European Heart Journal, Vol. 35, No. 19, 05.2014, p. 1255-1262.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Intravenous sodium nitrite in acute ST-elevation myocardial infarction
T2 - a randomized controlled trial (NIAMI)
AU - Siddiqi, Nishat
AU - Neil, Christopher
AU - Bruce, Margaret
AU - Maclennan, Graeme
AU - Cotton, Seonaidh Claire
AU - Papadopoulou, Sofia
AU - Feelisch, Martin
AU - Bunce, Nicholas
AU - Lim, Pitt O
AU - Hildick-Smith, David
AU - Horowitz, John
AU - Madhani, Melanie
AU - Boon, Nicholas
AU - Dawson, Dana
AU - Kaski, Juan Carlos
AU - Frenneaux, Michael
AU - NIAMI investigators
N1 - Funding This study was funded by the UK Medical Research Council. Funding to pay the Open Access publication charges for this article was provided by the University of Aberdeen. Acknowledgements We would like to thank our patients and the staff of the cardiology and radiology/cardiac MRI departments at all sites. We are grateful for the support of the staff at the Centre for Healthcare Randomised Trials at the University of Aberdeen
PY - 2014/5
Y1 - 2014/5
N2 - Despite prompt revascularization of acute myocardial infarction (AMI), substantial myocardial injury may occur, in part a consequence of ischaemia reperfusion injury (IRI). There has been considerable interest in therapies that may reduce IRI. In experimental models of AMI, sodium nitrite substantially reduces IRI. In this doubleblind randomized placebo controlled parallel-group trial, we investigated the effects of sodium nitrite administered immediately prior to reperfusion in patients with acute ST-elevation myocardial infarction (STEMI).
AB - Despite prompt revascularization of acute myocardial infarction (AMI), substantial myocardial injury may occur, in part a consequence of ischaemia reperfusion injury (IRI). There has been considerable interest in therapies that may reduce IRI. In experimental models of AMI, sodium nitrite substantially reduces IRI. In this doubleblind randomized placebo controlled parallel-group trial, we investigated the effects of sodium nitrite administered immediately prior to reperfusion in patients with acute ST-elevation myocardial infarction (STEMI).
KW - acute myocardial infarction
KW - ischaemia-reperfusion injury
KW - cardioprotection
KW - nitrite
U2 - 10.1093/eurheartj/ehu096
DO - 10.1093/eurheartj/ehu096
M3 - Article
C2 - 24639423
VL - 35
SP - 1255
EP - 1262
JO - European Heart Journal
JF - European Heart Journal
SN - 0195-668X
IS - 19
ER -