Intravenous sodium nitrite in acute ST-elevation myocardial infarction: a randomized controlled trial (NIAMI)

Nishat Siddiqi, Christopher Neil, Margaret Bruce, Graeme Maclennan, Seonaidh Claire Cotton, Sofia Papadopoulou, Martin Feelisch, Nicholas Bunce, Pitt O Lim, David Hildick-Smith, John Horowitz, Melanie Madhani, Nicholas Boon, Dana Dawson, Juan Carlos Kaski, Michael Frenneaux, NIAMI investigators

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Abstract

Despite prompt revascularization of acute myocardial infarction (AMI), substantial myocardial injury may occur, in part a consequence of ischaemia reperfusion injury (IRI). There has been considerable interest in therapies that may reduce IRI. In experimental models of AMI, sodium nitrite substantially reduces IRI. In this doubleblind randomized placebo controlled parallel-group trial, we investigated the effects of sodium nitrite administered immediately prior to reperfusion in patients with acute ST-elevation myocardial infarction (STEMI).
Original languageEnglish
Pages (from-to)1255-1262
Number of pages8
JournalEuropean Heart Journal
Volume35
Issue number19
Early online date17 Mar 2014
DOIs
Publication statusPublished - May 2014

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Keywords

  • acute myocardial infarction
  • ischaemia-reperfusion injury
  • cardioprotection
  • nitrite

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