Intravenous sodium nitrite in acute ST-elevation myocardial infarction: a randomized controlled trial (NIAMI)

Nishat Siddiqi; Christopher Neil; Margaret Bruce; Graeme Maclennan; Seonaidh Claire Cotton; Sofia Papadopoulou; Martin Feelisch; Nicholas Bunce; Pitt O Lim; David Hildick-Smith; John Horowitz; Melanie Madhani; Nicholas Boon; Dana Dawson; Juan Carlos Kaski; Michael Frenneaux; NIAMI investigators

doi:10.1093/eurheartj/ehu096

Intravenous sodium nitrite in acute ST-elevation myocardial infarction: a randomized controlled trial (NIAMI)

Nishat Siddiqi, Christopher Neil, Margaret Bruce, Graeme Maclennan, Seonaidh Claire Cotton, Sofia Papadopoulou, Martin Feelisch, Nicholas Bunce, Pitt O Lim, David Hildick-Smith, John Horowitz, Melanie Madhani, Nicholas Boon, Dana Dawson, Juan Carlos Kaski, Michael Frenneaux, NIAMI investigators

Research output: Contribution to journal › Article › peer-review

91 Citations (Scopus)

9 Downloads (Pure)

Abstract

Despite prompt revascularization of acute myocardial infarction (AMI), substantial myocardial injury may occur, in part a consequence of ischaemia reperfusion injury (IRI). There has been considerable interest in therapies that may reduce IRI. In experimental models of AMI, sodium nitrite substantially reduces IRI. In this doubleblind randomized placebo controlled parallel-group trial, we investigated the effects of sodium nitrite administered immediately prior to reperfusion in patients with acute ST-elevation myocardial infarction (STEMI).

Original language	English
Pages (from-to)	1255-1262
Number of pages	8
Journal	European Heart Journal
Volume	35
Issue number	19
Early online date	17 Mar 2014
DOIs	https://doi.org/10.1093/eurheartj/ehu096
Publication status	Published - May 2014

Keywords

acute myocardial infarction
ischaemia-reperfusion injury
cardioprotection
nitrite

Access to Document

10.1093/eurheartj/ehu096Licence: CC BY-NC

Siddiqi 2014
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License(http://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Final published version, 389 KB

Fingerprint Dive into the research topics of 'Intravenous sodium nitrite in acute ST-elevation myocardial infarction: a randomized controlled trial (NIAMI)'. Together they form a unique fingerprint.

Dana Dawson
- School of Medicine, Medical Sciences & Nutrition, Applied Medicine - Chair in Cardiovascular Medicine
- Clinical Medicine
- Institute of Medical Sciences
Person: Clinical Academic
Graeme MacLennan
Person: Academic, Academic Related - Research

Cite this

Siddiqi, N., Neil, C., Bruce, M., Maclennan, G., Cotton, S. C., Papadopoulou, S., Feelisch, M., Bunce, N., Lim, P. O., Hildick-Smith, D., Horowitz, J., Madhani, M., Boon, N., Dawson, D., Kaski, J. C., Frenneaux, M., & NIAMI investigators (2014). Intravenous sodium nitrite in acute ST-elevation myocardial infarction: a randomized controlled trial (NIAMI). European Heart Journal, 35(19), 1255-1262. https://doi.org/10.1093/eurheartj/ehu096

Intravenous sodium nitrite in acute ST-elevation myocardial infarction : a randomized controlled trial (NIAMI). / Siddiqi, Nishat; Neil, Christopher; Bruce, Margaret; Maclennan, Graeme; Cotton, Seonaidh Claire; Papadopoulou, Sofia; Feelisch, Martin; Bunce, Nicholas; Lim, Pitt O; Hildick-Smith, David; Horowitz, John; Madhani, Melanie; Boon, Nicholas; Dawson, Dana; Kaski, Juan Carlos; Frenneaux, Michael; NIAMI investigators.

In: European Heart Journal, Vol. 35, No. 19, 05.2014, p. 1255-1262.

Research output: Contribution to journal › Article › peer-review

Siddiqi, N, Neil, C, Bruce, M, Maclennan, G, Cotton, SC, Papadopoulou, S, Feelisch, M, Bunce, N, Lim, PO, Hildick-Smith, D, Horowitz, J, Madhani, M, Boon, N, Dawson, D, Kaski, JC, Frenneaux, M & NIAMI investigators 2014, 'Intravenous sodium nitrite in acute ST-elevation myocardial infarction: a randomized controlled trial (NIAMI)', European Heart Journal, vol. 35, no. 19, pp. 1255-1262. https://doi.org/10.1093/eurheartj/ehu096

Siddiqi, Nishat ; Neil, Christopher ; Bruce, Margaret ; Maclennan, Graeme ; Cotton, Seonaidh Claire ; Papadopoulou, Sofia ; Feelisch, Martin ; Bunce, Nicholas ; Lim, Pitt O ; Hildick-Smith, David ; Horowitz, John ; Madhani, Melanie ; Boon, Nicholas ; Dawson, Dana ; Kaski, Juan Carlos ; Frenneaux, Michael ; NIAMI investigators. / Intravenous sodium nitrite in acute ST-elevation myocardial infarction : a randomized controlled trial (NIAMI). In: European Heart Journal. 2014 ; Vol. 35, No. 19. pp. 1255-1262.

@article{f07b3fb194e4483683b9377b232b3a69,

title = "Intravenous sodium nitrite in acute ST-elevation myocardial infarction: a randomized controlled trial (NIAMI)",

abstract = "Despite prompt revascularization of acute myocardial infarction (AMI), substantial myocardial injury may occur, in part a consequence of ischaemia reperfusion injury (IRI). There has been considerable interest in therapies that may reduce IRI. In experimental models of AMI, sodium nitrite substantially reduces IRI. In this doubleblind randomized placebo controlled parallel-group trial, we investigated the effects of sodium nitrite administered immediately prior to reperfusion in patients with acute ST-elevation myocardial infarction (STEMI).",

keywords = "acute myocardial infarction, ischaemia-reperfusion injury, cardioprotection, nitrite",

author = "Nishat Siddiqi and Christopher Neil and Margaret Bruce and Graeme Maclennan and Cotton, {Seonaidh Claire} and Sofia Papadopoulou and Martin Feelisch and Nicholas Bunce and Lim, {Pitt O} and David Hildick-Smith and John Horowitz and Melanie Madhani and Nicholas Boon and Dana Dawson and Kaski, {Juan Carlos} and Michael Frenneaux and {NIAMI investigators}",

note = "Funding This study was funded by the UK Medical Research Council. Funding to pay the Open Access publication charges for this article was provided by the University of Aberdeen. Acknowledgements We would like to thank our patients and the staff of the cardiology and radiology/cardiac MRI departments at all sites. We are grateful for the support of the staff at the Centre for Healthcare Randomised Trials at the University of Aberdeen",

year = "2014",

month = may,

doi = "10.1093/eurheartj/ehu096",

language = "English",

volume = "35",

pages = "1255--1262",

journal = "European Heart Journal",

issn = "0195-668X",

publisher = "OXFORD UNIV PRESS",

number = "19",

}

TY - JOUR

T1 - Intravenous sodium nitrite in acute ST-elevation myocardial infarction

T2 - a randomized controlled trial (NIAMI)

AU - Siddiqi, Nishat

AU - Neil, Christopher

AU - Bruce, Margaret

AU - Maclennan, Graeme

AU - Cotton, Seonaidh Claire

AU - Papadopoulou, Sofia

AU - Feelisch, Martin

AU - Bunce, Nicholas

AU - Lim, Pitt O

AU - Hildick-Smith, David

AU - Horowitz, John

AU - Madhani, Melanie

AU - Boon, Nicholas

AU - Dawson, Dana

AU - Kaski, Juan Carlos

AU - Frenneaux, Michael

AU - NIAMI investigators

N1 - Funding This study was funded by the UK Medical Research Council. Funding to pay the Open Access publication charges for this article was provided by the University of Aberdeen. Acknowledgements We would like to thank our patients and the staff of the cardiology and radiology/cardiac MRI departments at all sites. We are grateful for the support of the staff at the Centre for Healthcare Randomised Trials at the University of Aberdeen

PY - 2014/5

Y1 - 2014/5

N2 - Despite prompt revascularization of acute myocardial infarction (AMI), substantial myocardial injury may occur, in part a consequence of ischaemia reperfusion injury (IRI). There has been considerable interest in therapies that may reduce IRI. In experimental models of AMI, sodium nitrite substantially reduces IRI. In this doubleblind randomized placebo controlled parallel-group trial, we investigated the effects of sodium nitrite administered immediately prior to reperfusion in patients with acute ST-elevation myocardial infarction (STEMI).

AB - Despite prompt revascularization of acute myocardial infarction (AMI), substantial myocardial injury may occur, in part a consequence of ischaemia reperfusion injury (IRI). There has been considerable interest in therapies that may reduce IRI. In experimental models of AMI, sodium nitrite substantially reduces IRI. In this doubleblind randomized placebo controlled parallel-group trial, we investigated the effects of sodium nitrite administered immediately prior to reperfusion in patients with acute ST-elevation myocardial infarction (STEMI).

KW - acute myocardial infarction

KW - ischaemia-reperfusion injury

KW - cardioprotection

KW - nitrite

U2 - 10.1093/eurheartj/ehu096

DO - 10.1093/eurheartj/ehu096

M3 - Article

C2 - 24639423

VL - 35

SP - 1255

EP - 1262

JO - European Heart Journal

JF - European Heart Journal

SN - 0195-668X

IS - 19

ER -

Intravenous sodium nitrite in acute ST-elevation myocardial infarction: a randomized controlled trial (NIAMI)

Abstract

Keywords

Access to Document

Dana Dawson

Graeme MacLennan

Cite this