Abstract
Despite prompt revascularization of acute myocardial infarction (AMI), substantial myocardial injury may occur, in part a consequence of ischaemia reperfusion injury (IRI). There has been considerable interest in therapies that may reduce IRI. In experimental models of AMI, sodium nitrite substantially reduces IRI. In this doubleblind randomized placebo controlled parallel-group trial, we investigated the effects of sodium nitrite administered immediately prior to reperfusion in patients with acute ST-elevation myocardial infarction (STEMI).
Original language | English |
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Pages (from-to) | 1255-1262 |
Number of pages | 8 |
Journal | European Heart Journal |
Volume | 35 |
Issue number | 19 |
Early online date | 17 Mar 2014 |
DOIs | |
Publication status | Published - May 2014 |
Keywords
- acute myocardial infarction
- ischaemia-reperfusion injury
- cardioprotection
- nitrite
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Profiles
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Seonaidh Cotton
- Public Health, Health Services and Primary Care
- School of Medicine, Medical Sciences & Nutrition, Health Services Research Unit (HSRU) - Trial Manager
Person: Academic Related - AST 5-9
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Dana Dawson
- School of Medicine, Medical Sciences & Nutrition, Applied Medicine - Chair in Cardiovascular Medicine
- Clinical Medicine
- Institute of Medical Sciences
Person: Clinical Academic
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Graeme MacLennan
- School of Medicine, Medical Sciences & Nutrition, Health Services Research Unit (HSRU) - Director (CHaRT)
- Public Health, Health Services and Primary Care
- Institute of Applied Health Sciences
Person: Academic, Academic Related - Research