Intravenous sodium nitrite in acute ST-elevation myocardial infarction

a randomized controlled trial (NIAMI)

Nishat Siddiqi, Christopher Neil, Margaret Bruce, Graeme Maclennan, Seonaidh Claire Cotton, Sofia Papadopoulou, Martin Feelisch, Nicholas Bunce, Pitt O Lim, David Hildick-Smith, John Horowitz, Melanie Madhani, Nicholas Boon, Dana Dawson, Juan Carlos Kaski, Michael Frenneaux, NIAMI investigators

Research output: Contribution to journalArticle

78 Citations (Scopus)
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Abstract

Despite prompt revascularization of acute myocardial infarction (AMI), substantial myocardial injury may occur, in part a consequence of ischaemia reperfusion injury (IRI). There has been considerable interest in therapies that may reduce IRI. In experimental models of AMI, sodium nitrite substantially reduces IRI. In this doubleblind randomized placebo controlled parallel-group trial, we investigated the effects of sodium nitrite administered immediately prior to reperfusion in patients with acute ST-elevation myocardial infarction (STEMI).
Original languageEnglish
Pages (from-to)1255-1262
Number of pages8
JournalEuropean Heart Journal
Volume35
Issue number19
Early online date17 Mar 2014
DOIs
Publication statusPublished - May 2014

Fingerprint

Sodium Nitrite
Reperfusion Injury
Randomized Controlled Trials
Myocardial Infarction
Reperfusion
Theoretical Models
Placebos
Wounds and Injuries
ST Elevation Myocardial Infarction
Therapeutics

Keywords

  • acute myocardial infarction
  • ischaemia-reperfusion injury
  • cardioprotection
  • nitrite

Cite this

Intravenous sodium nitrite in acute ST-elevation myocardial infarction : a randomized controlled trial (NIAMI). / Siddiqi, Nishat; Neil, Christopher; Bruce, Margaret; Maclennan, Graeme; Cotton, Seonaidh Claire; Papadopoulou, Sofia; Feelisch, Martin; Bunce, Nicholas; Lim, Pitt O; Hildick-Smith, David; Horowitz, John; Madhani, Melanie; Boon, Nicholas; Dawson, Dana; Kaski, Juan Carlos; Frenneaux, Michael; NIAMI investigators.

In: European Heart Journal, Vol. 35, No. 19, 05.2014, p. 1255-1262.

Research output: Contribution to journalArticle

Siddiqi, N, Neil, C, Bruce, M, Maclennan, G, Cotton, SC, Papadopoulou, S, Feelisch, M, Bunce, N, Lim, PO, Hildick-Smith, D, Horowitz, J, Madhani, M, Boon, N, Dawson, D, Kaski, JC, Frenneaux, M & NIAMI investigators 2014, 'Intravenous sodium nitrite in acute ST-elevation myocardial infarction: a randomized controlled trial (NIAMI)', European Heart Journal, vol. 35, no. 19, pp. 1255-1262. https://doi.org/10.1093/eurheartj/ehu096
Siddiqi, Nishat ; Neil, Christopher ; Bruce, Margaret ; Maclennan, Graeme ; Cotton, Seonaidh Claire ; Papadopoulou, Sofia ; Feelisch, Martin ; Bunce, Nicholas ; Lim, Pitt O ; Hildick-Smith, David ; Horowitz, John ; Madhani, Melanie ; Boon, Nicholas ; Dawson, Dana ; Kaski, Juan Carlos ; Frenneaux, Michael ; NIAMI investigators. / Intravenous sodium nitrite in acute ST-elevation myocardial infarction : a randomized controlled trial (NIAMI). In: European Heart Journal. 2014 ; Vol. 35, No. 19. pp. 1255-1262.
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