Invasive Fungal Infections in Patients with Chronic Granulomatous Disease

Stefanie Henriet, Paul E. Verweij, Steven M. Holland, Adilia Warris

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

43 Citations (Scopus)

Abstract

Invasive fungal infections are a major threat for chronic granulomatous disease (CGD) patients. The present study provides a comprehensive overview of published invasive fungal infections in the CGD host through an extensive review of epidemiological, clinical, diagnostic and therapeutic data. In addition to the often mild clinical presentation, the currently used diagnostics for invasive aspergillosis have low sensitivity in CGD patients and cannot be easily translated to this non-neutropenic host. Aspergillus fumigatus and A. nidulans are the most commonly isolated species. A. nidulans infections are seldom reported in other immunocompromised patients, indicating a unique interaction between this fungus and the CGD host. The occurrence of mucormycosis is mainly noted in the setting of treatment of inflammatory complications with immunosuppressive drugs. Candidainfections are infrequently seen and do not cause mucocutaneous disease but do show an age-dependent clinical presentation. The CGD patient is susceptible to a wide range of fungal pathogens, indicating the need to determine the causative fungus, often by invasive diagnostics, to guide optimal and rational treatment. This review summarizes current understanding of invasive fungal infections in patients with CGD and will serve as a starting point to guide optimal treatment strategies and to direct further research aimed at improving outcomes.
Original languageEnglish
Title of host publicationHot Topics in Infection and Immunity in Children IX
EditorsNigel Curtis, Adam Finn, Andrew J. Pollard
Place of PublicationNew York
PublisherSpringer
Pages27-55
Number of pages29
ISBN (Electronic)9781461447269
ISBN (Print)9781461447252
DOIs
Publication statusPublished - 2013

Publication series

NameAdvances in Experimental Medicine and Biology
PublisherSpringer
Volume764
ISSN (Print)0065-2598

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Keywords

  • Fungal Infection
  • Antifungal Therapy
  • Invasive Aspergillosis
  • Chronic Granulomatous Disease
  • Invasive Fungal Infection

Cite this

Henriet, S., Verweij, P. E., Holland, S. M., & Warris, A. (2013). Invasive Fungal Infections in Patients with Chronic Granulomatous Disease. In N. Curtis, A. Finn, & A. J. Pollard (Eds.), Hot Topics in Infection and Immunity in Children IX (pp. 27-55). [3] (Advances in Experimental Medicine and Biology; Vol. 764). Springer . https://doi.org/10.1007/978-1-4614-4726-9_3