Inverse association between gastroesophageal reflux and blood pressure: Results of a large community based study

Liam J. Murray, Peter McCarron, Roger B. McCorry*, Lesley A. Anderson, Athene J. Lane, Brian T. Johnston, George Davey Smith, Richard F. Harvey

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: In a cross-sectional community based study, as part of a randomised controlled trial of eradication of Helicobacter pylori infection, the association between blood pressure and symptoms of gastro-oesophageal reflux was examined. Methods: Linear regression was used to examine the association between systolic and diastolic blood pressure and the frequency of heartburn and acid regurgitation in 4,902 of 10,537 participants aged 20-59 years. Results In multivariable analyses, adjusted mean systolic blood pressure was 4.2 (95% confidence interval 1.5 to 7.0) mm Hg lower in participants with daily acid regurgitation compared to those with less frequent symptoms. Similarly, for diastolic blood pressure, a reduction of 2.1 (0.0 to 4.3) mm Hg wasobserved. Conclusion: People who experience daily symptoms of gastro-oesophageal reflux have lower blood pressure than people with less frequent or no symptoms. It is possible that factors influencing nitric oxide concentrations both at the lower oesophageal sphincter and within the vasculature may be involved. This hypothesis requires confirmation.

Original languageEnglish
Article number10
JournalBMC Gastroenterology
Volume8
DOIs
Publication statusPublished - 15 Apr 2008

ASJC Scopus subject areas

  • Gastroenterology

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    Murray, L. J., McCarron, P., McCorry, R. B., Anderson, L. A., Lane, A. J., Johnston, B. T., Smith, G. D., & Harvey, R. F. (2008). Inverse association between gastroesophageal reflux and blood pressure: Results of a large community based study. BMC Gastroenterology, 8, [10]. https://doi.org/10.1186/1471-230X-8-10