Invertebrate and fish cytokines

G Scapigliati, S Bird, C J Secombes

Research output: Contribution to journalLiterature review

18 Citations (Scopus)

Abstract

Cytokine-like molecules are well described in invertebrates, although most recent studies have revealed that there is analogy, rather than homology, between invertebrate and vertebrate cytokine-like activities. Cytokines certainly appeared early in the evolution of vertebrates, dating back some 400 millions years. Here, evidence will be reviewed and updated of the presence of these molecules in jawed fish and in particular, in bony fish, which represent the oldest group displaying true functionality of immune system as known in modern vertebrates. Many studies during the last ten years have confirmed the presence of functional homologues of mammalian cytokines in fish. In this review, particular attention will be focussed on IL-1 beta, a very ancient defence cytokine recently sequenced in two species, rainbow trout (Oncorhynchus mykiss) and carp (Cyprinus carpio), Original data on the partial peptide sequence of IL-1 beta in the mediterranean sea bass Dicentrarchus labrax are also presented.

Original languageEnglish
Pages (from-to)354-361
Number of pages8
JournalEuropean Cytokine Network
Volume11
Publication statusPublished - 2000

Keywords

  • invertebrates
  • teleost fish
  • sea bass
  • cytokines
  • IL-1 beta
  • evolution
  • TROUT ONCORHYNCHUS-MYKISS
  • MACROPHAGE-ACTIVATING FACTOR
  • CYPRINUS-CARPIO L
  • RAINBOW-TROUT
  • IMMUNE-RESPONSE
  • DROSOPHILA TOLL
  • LYMPHOCYTE HETEROGENEITY
  • AEROMONAS-SALMONICIDA
  • MOLECULAR-CLONING
  • CHANNEL CATFISH

Cite this

Scapigliati, G., Bird, S., & Secombes, C. J. (2000). Invertebrate and fish cytokines. European Cytokine Network, 11, 354-361.

Invertebrate and fish cytokines. / Scapigliati, G ; Bird, S ; Secombes, C J .

In: European Cytokine Network, Vol. 11, 2000, p. 354-361.

Research output: Contribution to journalLiterature review

Scapigliati, G, Bird, S & Secombes, CJ 2000, 'Invertebrate and fish cytokines', European Cytokine Network, vol. 11, pp. 354-361.
Scapigliati, G ; Bird, S ; Secombes, C J . / Invertebrate and fish cytokines. In: European Cytokine Network. 2000 ; Vol. 11. pp. 354-361.
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AU - Bird, S

AU - Secombes, C J

PY - 2000

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N2 - Cytokine-like molecules are well described in invertebrates, although most recent studies have revealed that there is analogy, rather than homology, between invertebrate and vertebrate cytokine-like activities. Cytokines certainly appeared early in the evolution of vertebrates, dating back some 400 millions years. Here, evidence will be reviewed and updated of the presence of these molecules in jawed fish and in particular, in bony fish, which represent the oldest group displaying true functionality of immune system as known in modern vertebrates. Many studies during the last ten years have confirmed the presence of functional homologues of mammalian cytokines in fish. In this review, particular attention will be focussed on IL-1 beta, a very ancient defence cytokine recently sequenced in two species, rainbow trout (Oncorhynchus mykiss) and carp (Cyprinus carpio), Original data on the partial peptide sequence of IL-1 beta in the mediterranean sea bass Dicentrarchus labrax are also presented.

AB - Cytokine-like molecules are well described in invertebrates, although most recent studies have revealed that there is analogy, rather than homology, between invertebrate and vertebrate cytokine-like activities. Cytokines certainly appeared early in the evolution of vertebrates, dating back some 400 millions years. Here, evidence will be reviewed and updated of the presence of these molecules in jawed fish and in particular, in bony fish, which represent the oldest group displaying true functionality of immune system as known in modern vertebrates. Many studies during the last ten years have confirmed the presence of functional homologues of mammalian cytokines in fish. In this review, particular attention will be focussed on IL-1 beta, a very ancient defence cytokine recently sequenced in two species, rainbow trout (Oncorhynchus mykiss) and carp (Cyprinus carpio), Original data on the partial peptide sequence of IL-1 beta in the mediterranean sea bass Dicentrarchus labrax are also presented.

KW - invertebrates

KW - teleost fish

KW - sea bass

KW - cytokines

KW - IL-1 beta

KW - evolution

KW - TROUT ONCORHYNCHUS-MYKISS

KW - MACROPHAGE-ACTIVATING FACTOR

KW - CYPRINUS-CARPIO L

KW - RAINBOW-TROUT

KW - IMMUNE-RESPONSE

KW - DROSOPHILA TOLL

KW - LYMPHOCYTE HETEROGENEITY

KW - AEROMONAS-SALMONICIDA

KW - MOLECULAR-CLONING

KW - CHANNEL CATFISH

M3 - Literature review

VL - 11

SP - 354

EP - 361

JO - European Cytokine Network

JF - European Cytokine Network

SN - 1148-5493

ER -