Investigating the persistence of tick-borne pathogens via the R0 model

A. Harrison, W. I. Montgomery, K. J. Brown

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

In the epidemiology of infectious diseases, the basic reproduction number, R0, has a number of important applications, most notably it can be used to predict whether a pathogen is likely to become established, or persist, in a given area. We used the R0 model to investigate the persistence of 3 tick-borne pathogens; Babesia microti, Anaplasma phagocytophilum and Borrelia burgdorferi sensu lato in an Apodemus sylvaticus-Ixodes ricinus system. The persistence of these pathogens was also determined empirically by screening questing ticks and wood mice by PCR. All 3 pathogens behaved differently in response to changes in the proportion of transmission hosts on which I. ricinus fed, the efficiency of transmission between the host and ticks and the abundance of larval and nymphal ticks found on small mammals. Empirical data supported theoretical predictions of the R0 model. The transmission pathway employed and the duration of systemic infection were also identified as important factors responsible for establishment or persistence of tick-borne pathogens in a given tick-host system. The current study demonstrates how the R0 model can be put to practical use to investigate factors affecting tick-borne pathogen persistence, which has important implications for animal and human health worldwide.
Original languageEnglish
Pages (from-to)896-905
Number of pages10
JournalParasitology
Volume138
Issue number7
Early online date26 Apr 2011
DOIs
Publication statusPublished - Jun 2011

Fingerprint

Ticks
ticks
pathogens
Ixodes
Ixodes ricinus
Babesia microti
Basic Reproduction Number
Anaplasma phagocytophilum
Borrelia burgdorferi Group
Murinae
Apodemus sylvaticus
Apodemus
animal and human health
Borrelia burgdorferi
small mammals
infectious diseases
Communicable Diseases
epidemiology
Mammals
Epidemiology

Keywords

  • tick-borne disease
  • zoonosis
  • basic reproduction number
  • Ixodes ricinus

Cite this

Investigating the persistence of tick-borne pathogens via the R0 model. / Harrison, A.; Montgomery, W. I.; Brown, K. J.

In: Parasitology, Vol. 138, No. 7, 06.2011, p. 896-905.

Research output: Contribution to journalArticle

Harrison, A, Montgomery, WI & Brown, KJ 2011, 'Investigating the persistence of tick-borne pathogens via the R0 model', Parasitology, vol. 138, no. 7, pp. 896-905. https://doi.org/10.1017/S0031182011000400
Harrison, A. ; Montgomery, W. I. ; Brown, K. J. / Investigating the persistence of tick-borne pathogens via the R0 model. In: Parasitology. 2011 ; Vol. 138, No. 7. pp. 896-905.
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