Investigation of the genetic association between quantitative measures of psychosis and schizophrenia: A polygenic risk score analysis

The Schizophrenia Psychiatric Genomic Consortium

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

The presence of subclinical levels of psychosis in the general population may imply that schizophrenia is the extreme expression of more or less continuously distributed traits in the population. In a previous study, we identified five quantitative measures of schizophrenia (positive, negative, disorganisation, mania, and depression scores). The aim of this study is to examine the association between a direct measure of genetic risk of schizophrenia and the five quantitative measures of psychosis. Estimates of the log of the odds ratios of case/control allelic association tests were obtained from the Psychiatric GWAS Consortium (PGC) (minus our sample) which included genome-wide genotype data of 8,690 schizophrenia cases and 11,831 controls. These data were used to calculate genetic risk scores in 314 schizophrenia cases and 148 controls from the Netherlands for whom genotype data and quantitative symptom scores were available. The genetic risk score of schizophrenia was significantly associated with case-control status (p<0.0001). In the case-control sample, the five psychosis dimensions were found to be significantly associated with genetic risk scores; the correlations ranged between.15 and.27 (all p<.001). However, these correlations were not significant in schizophrenia cases or controls separately. While this study confirms the presence of a genetic risk for schizophrenia as categorical diagnostic trait, we did not find evidence for the genetic risk underlying quantitative schizophrenia symptom dimensions. This does not necessarily imply that a genetic basis is nonexistent, but does suggest that it is distinct from the polygenic risk score for schizophrenia.

Original languageEnglish
Article numbere37852
Number of pages7
JournalPloS ONE
Volume7
Issue number6
Early online date22 Jun 2012
DOIs
Publication statusPublished - 22 Jun 2012

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Risk analysis
Psychotic Disorders
Schizophrenia
Genotype
schizophrenia
genotype
Genome-Wide Association Study
Genes
Bipolar Disorder
Netherlands
odds ratio
Population
Psychiatry
Odds Ratio
Genome
Depression
sampling
genome

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Investigation of the genetic association between quantitative measures of psychosis and schizophrenia : A polygenic risk score analysis. / The Schizophrenia Psychiatric Genomic Consortium.

In: PloS ONE, Vol. 7, No. 6, e37852, 22.06.2012.

Research output: Contribution to journalArticle

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